Navigation Links
Mayo researchers describe measles viral protein movement
Date:1/9/2011

ROCHESTER, Minn. -- Mayo Clinic researchers have shown that proteins on the surface of a cell twist a viral protein into position, allowing the virus to start infection and cause disease, all in a movement as graceful as a ballroom dance. The findings appear in the current online issue of Nature Structural & Molecular Biology.

A team led by Roberto Cattaneo, Ph.D., a Mayo molecular biologist, describes the crucial initial steps taken by attachment proteins of the measles virus and related respiratory viruses with their cellular partners, the receptors. To get there, the research team built "handles" at different locations on a viral attachment protein, allowing them to be grabbed by an artificial receptor to start the dance.

Visualize the measles virus. It is small and has an outer "envelope" with two proteins, one that interacts with a cellular receptor, its dance partner, and another that fuses the viral envelope with the cell membrane, starting infection.

Measles virus, while long targeted for eradication through vaccination, still affects 10 million people and kills some 197,000 each year around the world. A long-running question is how the cell entry process begins.

"It was known that the viral attachment proteins always come in pairs, and recently it became clear that two pairs form a quartet," Dr. Cattaneo says. "Pairs initially face each other, and we show here that the upper bodies separate when the dance begins. We suggest that they then engage a partner from the other pair of the quartet, while the legs are still dancing with those of the original partner."

As this dance continues, the cellular receptors weaken the layer of attachment proteins that protects a lower layer of fusion proteins. When enough quartets become twisted and unstable, the top layer fails abruptly. This failure causes unfolding of the proteins in the lower layer, and, in turn, fusion with the cellular membrane. The viral genome,
'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... compete with members of their own species. However, ... into their competitive ability. Some individuals are highly ... resources, while others seem to avoid competition, instead ... are left over for them. Moreover, the degree ... to fluctuate considerably over time. A theoretical study ...
(Date:10/28/2014)... in German . ... acquire sufficient food when times are lean? By studying ... d,Ivoire researchers of the Max Planck Institute for Evolutionary ... how great apes can acquire extra energy needed to ... their sleeping nests more en route to breakfast sites ...
(Date:10/28/2014)... be building a hybrid micro-grid which will integrate ... in the region, the hybrid micro-grid will test ... diesel, storage and power-to-gas technologies, and ensure these ... built under the new Renewable Energy Integration Demonstrator- ... located offshore at Semakau Landfill and is expected ...
Breaking Biology News(10 mins):Evolution of competitiveness 2Evolution of competitiveness 3The early chimp gets the fig 2The early chimp gets the fig 3NTU to build region's first renewable energy integration demonstration micro-grid 2NTU to build region's first renewable energy integration demonstration micro-grid 3
... the growing demand for organic food products has led to ... of Science, University of Copenhagen, a European research project will ... of a food product and deciding whether or not it ... as olive oil, coffee and wine are sold at a ...
... Among overweight and obese adults, a diet rich ... and other high-fiber foods, significantly reduces markers of inflammation ... by Fred Hutchinson Cancer Research Center. Such a "low-glycemic-load" ... also increases a hormone that helps regulate the metabolism ...
... Every year, a group of anti-whaling nonprofit organizations that ... spend, by conservative estimates, some $25 million on a ... And every year, commercial whaling not only continues, but ... number of whales harvested annually has doubled since the ...
Cached Biology News:Research prevents eco-fraud 2Research prevents eco-fraud 3A diet rich in slowly digested carbs reduces markers of inflammation in overweight and obese adults 2Can we save the whales by putting a price on them? 2Can we save the whales by putting a price on them? 3
(Date:10/26/2014)... October 26, 2014 The report "Protective ... Application - Global Trends & Forecast to 2019", defines ... and forecasting of volume consumed and value generated. The ... KT in 2014 to 6,701.3 KT by 2019, at ... Browse 91 market data tables and 22 figures spread ...
(Date:10/25/2014)... California (PRWEB) October 23, 2014 ... a specialty pharmaceutical company devoted to bringing new ... partnerships in 2015. , ViaDerma has developed an ... allows for rapid mass transfer of pharmaceutical active ... body to provide immediate localized therapy. The transdermal ...
(Date:10/25/2014)... According to new market research report "Data ... Enterprise, Telecom), by Design Types (Electrical, Mechanical), and ... 3, Tier 4) - Global Forecast to 2019", ... Center Construction Market into various segments with an ... report also identifies the factors driving this market, ...
(Date:10/25/2014)... The Workgroup for Electronic Data ... on the use of health IT to create ... of four new co-chairs to the organization’s Security ... ,     Peter Dumont, Senior Director – Privacy ... Deloitte Consulting LLP ,     Deidre Rodriguez, Director ...
Breaking Biology Technology:Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 2Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 3Protective Coatings Market Poised to Reach $18,431.8 Million by 2019 - Report by MarketsandMarkets 4ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 2ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 3Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 2Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 3Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 4WEDI Appoints Four New Security and Privacy Workgroup Co-chairs 2
... works how people can tune in to a single ... solved this week in the journal Nature by ... Psychologists have known for decades about the so-called "cocktail ... in which it was coined. It is the remarkable human ...
... are single-cell plants that comprise nature,s smallest and ... thrive is water, light, and air. When bred ... to wastewater treatment to biofuels. Current microalgae breeding ... allowed by the laws of nature. Scientists at ...
... , Expanded clinical study ...   TMC435 and BMS-986094 (formerly ... in clinical trial , ... on the development of high-value treatments for infectious diseases, ...
Cached Biology Technology:How selective hearing works in the brain 2How selective hearing works in the brain 3Medivir Announces TMC435 in an Expanded Clinical Collaboration 2Medivir Announces TMC435 in an Expanded Clinical Collaboration 3Medivir Announces TMC435 in an Expanded Clinical Collaboration 4
Gamma delta T Lymphocytes Purified Anti-Porcine clone MAC320, Isotype Rat IgG 2a , kappa, 0.1 mg Consult technical datasheet for details....
...
SAPK/JNK Antibody...
Molecular Biology grade. Ideally suited for DNA and RNA separation and recovery. High gel strength. Gelling temp. 36C. Melting temp. 88C. EEO: 0.05-0.13 Resolution 0.2-40 kb; Rnase/Dnase: none detec...
Biology Products: