Navigation Links
Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells
Date:3/29/2009

JACKSONVILLE, Fla. Based on research that reveals new insight into mechanisms that allow invasive tumor cells to move, researchers at the Mayo Clinic campus in Florida have a new understanding about how to stop cancer from spreading. A cancer that spreads elsewhere in the body, known as metastasis, is the process that most often leads to death from the disease.

In the March 29 online issue of Nature Cell Biology, researchers say that a molecule known as protein kinase D1 (PKD1) is key to the ability of a tumor cell to "remodel" its structure, enabling it to migrate and invade. The researchers found that if PKD1 is active, tumor cells cannot move, a finding they say explains why PKD1 is silenced in some invasive cancers.

During metastasis, invasive cancer cells respond to biological signals to move away from a primary tumor. Multiple research groups at Mayo Clinic in Florida are especially interested in this process. One team, led by cancer biologist Peter Storz, Ph.D., has been investigating a process known as actin remodeling at the leading edge - the most forward point - of these migrating tumor cells.

"The events that reorganize the actin cytoskeleton at the leading edge are complex a multitude of molecules act in concert," Dr. Storz says. "But it appears that PKD1 must be turned off if cancer cells are to migrate."

Actin filaments help make up the cytoskeleton of cells. For cancer cells to move, the actin-based cell structure has to be continually reorganized, Dr. Storz says, and to do this, new actin filaments need to be generated to shift the cell forward.

Dr. Storz' group discovered that PKD1 was critical to this process. The researchers found that PKD1 inhibits another protein known as slingshot, which regulates the severing of existing actin structures so that new actin filaments can be synthesized, an event that is essential for cell movement.

The researchers used methods to deplete tumo
'/>"/>

Contact: Paul Scotti
scotti.paul@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC Davis bench-to-bedside research: Promising treatment in clinical trials
2. Alzheimers disease therapeutic prevents long-term damage from TBI in pre-clinical studies
3. Researchers win award for best clinical paper in orthopedic physical therapy
4. ABC publishes monograph on scientific and clinical research of Sinupret
5. Mayo Clinic researchers suspect a novel gene is causing restless legs syndrome in a large family
6. TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug
7. 3 new informatics pilot projects to aid clinical and translational scientists nationwide
8. Genome Medicine: Bridging the gap between research and clinical practice
9. Far-reaching genetics topics to be addressed: 2009 Annual Clinical Genetics Meeting, March 25-29
10. Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases
11. TGen, Scottsdale Healthcare, Mayo Clinic study new drug to stimulate immune system of cancer victims
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... , Dec. 22, 2014 Research and ... announced the addition of the "The ... to their offering. ... provides an overview of the global digital ... to control and monitor piracy by securely ...
(Date:12/19/2014)...  23andMe, Inc., the leading personal genetics company, today ... differences in genetic ancestry of individuals from across ... immigrants first arrived more than four hundred years ago, ... as a meeting place for peoples from different continents. ... mixing of peoples with African, European, and American origins ...
(Date:12/17/2014)...  HITLAB SM announced today its completion ... confirm its adherence to current U.S. Food and ... to conduct regulated smart device and smart phone ... safety and research quality. "HITLAB is ... delivery with innovative technology," said Laura Pugliese ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... of microwave oven technology that most people use to heat ... solar energy industry, providing a new way to make thin-film ... Engineers at Oregon State University have for the first time ... of copper zinc tin sulfide, a promising solar cell compound ...
... functions in the central nervous system, such as the ... response to neurotrauma or stroke. Reduces brain ... have earlier demonstrated that astrocytes reduce the brain tissue ... neural stem cells can be largely improved by modulating ...
... the longer lifespans of bigger creatures may be explained by ... (www.constructal.org). What this law proposes is that anything that ... evolve toward the same basic configuration out of a need ... same basic law applies to all bodies in motion, be ...
Cached Biology News:Microwave ovens may help produce lower cost solar energy technology 2Astrocytes control the generation of new neurons from neural stem cells 2Bigger creatures live longer, travel farther for a reason 2
(Date:12/22/2014)... VIEJO, Calif. , Dec. 22, 2014  ( ... that CoPatient, an online medical bill review and advocacy ... offering in the FREE WellCard Savings discount health services ... medical bill that was more than they expected to ... members reduce health care costs, WellCard Savings is pleased ...
(Date:12/22/2014)... Fertility Associates of Memphis has announced a ... a network of more than 20 contributing fertility ... fast access to a national pool of frozen ... Associates of Memphis is the only fertility clinic in ... Dr. William Kutteh , director of Fertility Associates ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of ... Nick Maroulis, Pharm.D. to the newly created position of ... this position, Dr. Maroulis will continue to manage the ... our multi-site pharmacies as the company expands. Dr. Maroulis ... time he has served in many different capacities in ...
(Date:12/19/2014)... , Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... today that they have been acquired by Roche (SIX: ... a privately held company that provides a big data ... sequencing (NGS) data for the academic and translational research ... Unit, and will continue to focus on development of ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... Jan. 13 /PRNewswire-Asia-FirstCall/ -- Genesis,Pharmaceuticals Enterprises, Inc. ... a U.S. pharmaceutical company with its principal ... announced that it engaged KPMG Huazhen,("KPMG"), a ... independent member firms,affiliated with KPMG International, to ...
... Johnston Blakely & Company, LLC, a,Boston-based life ... Michael,D. Webb has joined the firm as senior ... with the firm on internal and client-related activities ... placements, with a,particular focus on biopharmaceutical transactions. ...
... 1:00PM PTNEW YORK, Jan. 13 Keryx Biopharmaceuticals, Inc. ... S. Weiss, the Company,s Chairman and Chief Executive Officer, ... Annual Healthcare Conference being held in San Francisco.Mr. Weiss, ... at 1:00pm PT and will be accessible from the ...
Cached Biology Technology:Genesis Pharmaceuticals Appoints KPMG to Help Develop a SOX 404 Compliance Program 2Genesis Pharmaceuticals Appoints KPMG to Help Develop a SOX 404 Compliance Program 3Keryx Biopharmaceuticals to Present at the J.P. Morgan 27th Annual Healthcare Conference 2
Human Ig Lambda-chain, clone ICO-16, Monoclonal Antibody...
Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2). [Source:Uniprot/SWISSPROT;Acc:P19878] Antigen: Recombinant Protein E...
Rad51, N-terminal...
DDO Immunogen: DDO (NP_003640, 270 a.a. ~ 370 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Biology Products: