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Mayo: Variants in gene on X chromosome associated with increased susceptibility to Alzheimer's
Date:1/11/2009

y showing highly significant association, it is important to analyze many additional Alzheimer's disease cases and controls before drawing any final conclusions about the strength of the association and the degree of risk it confers on developing Alzheimer's disease."

PCDH11X encodes a protocadherin that is included in a family of cadherin molecules that promote cell-cell adhesion and signaling in the central nervous system. Some evidence suggests that protocadherins are processed by presenilins linked to early-onset familial forms of Alzheimer's disease, the researchers say.

"The goal now will be to conduct further studies of this gene to determine the precise mechanism by which genetic variation in PCDH11X influences the risk of Alzheimer's disease and if the findings can be translated to improved diagnostics and therapeutics," Dr. Carrasquillo says.


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Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

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