Navigation Links
Mayo: Variants in gene on X chromosome associated with increased susceptibility to Alzheimer's
Date:1/11/2009

the variant occurred in only 46 percent of unaffected men where a single copy was present. "When we compared Alzheimer's disease patients with unaffected controls, the largest and most significant difference was in women with two copies of the PCDH11X variant, who were found more frequently in the Alzheimer's disease group," Dr. Younkin says. "Compared to female non-carriers, the odds ratio was 1.75 for women with two copies of the variant and 1.26 for women with one copy. It was 1.18 for men with one copy compared to male non-carriers."

To put these findings in context, the odds ratio for two copies of the well-established, high-risk APOE 4 allele was 11.5 in the subjects assembled by the Mayo group, and it was 4.8 for one copy, Dr. Younkin says. APOE 4 is the highest-risk Alzheimer's disease susceptibility allele found to date. The association for women with one copy of the PCDH11X variant is similar to genetic associations now being reported for many diseases, but the strength of association when two copies were present is noteworthy particularly because the PCDH11X variant is so common, investigators say.

"It is always exciting to identify a new Alzheimer's disease gene," says Minerva Carrasquillo, Ph.D., instructor of neuroscience and first author of the study. "The search for genes that influence the risk of common complex diseases such as Alzheimer's disease has proven extremely difficult, as most of the genes involved in the etiology of such diseases tend individually to have only modest effects on risk.

"When we set out to scan the genome for Alzheimer's disease susceptibility genes, we were not at all certain that we would find any gene other than the well-established APOE gene. Fortunately, the unbiased genome-wide scan that we undertook enabled us to identify PCDH11X, a previously unsuspected gene on the X chromosome that is the first to show gender-specific effects."

Dr. Younkin says, "Even though this is a large stud
'/>"/>

Contact: Kevin Punsky
punsky.kevin@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Scientists associate 6 new genetic variants with heart disease risk factor
3. New genetic variants associated with lipid levels, risk for coronary artery disease
4. Genetic variants of USF1 are associated with the increased risk for cardiovascular disease
5. Interaction between gene variants may alter brain function in schizophrenia
6. Study identifies genetic variants giving rise to differences in metabolism
7. New gene variants present opportunities in nutrigenomics
8. Grant supports study of abnormal ring-shaped chromosomes
9. X-effect: female chromosome confirmed a prime driver of speciation
10. Bioclocks work by controlling chromosome coiling
11. Workman Lab characterizes novel regulator of chromosome function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)...   LaunchKey , the first decentralized mobile authentication ... of Things era, today announced the close of $3 ... led by Metamorphic Ventures with participation from ENIAC Ventures, ... others.  LaunchKey has raised $4 million to date, and ... and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... , Dec. 15, 2014 The ... make it easier to detect and prevent counterfeit ... Today the agency started performing an in-house ... will validate the authenticity of purchased microcircuits while ... new quality control measures will be conducted at ...
(Date:12/17/2014)... 16, 2014 Valencell, a leader in performance ... technology to industry leaders such as Intel, Jabra, Atlas, ... biometric wearable products. These products will be showcased at ... Las Vegas . "Our partners ... and robust – with the clinical data to back ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... statewide group of structural biologists with similar interests in ... on the University of Oklahoma,s Norman campus with the ... sophisticated robotics equipment. The idea for the ... facilitated a meeting among structural biologists from the OU ...
... has allowed a research team to uncover the mysteries ... time. In total, the bird flies more than 9,500 ... Columbretes Islands before reaching the island of Madagascar. Some ... show that these falcons migrate by both day and ...
... have thought about providing an exercise workout in the ... even those who are comatose - but a researcher ... Western Reserve University will be doing some bedside coaching ... muscles. Chris Winkelman, assistant professor of nursing, will ...
Cached Biology News:Migratory route of Eleonora's falcon revealed for first time 2ICU patients on ventilators flex and stretch in study at Case Western Reserve University 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... is the final part of a series on the Master of ... here. We pick up with three more of the program's ... ,Lynda Bader was ready for a change. , ,She had achieved ... government in Wisconsin, and she possessed extensive project management experience working ...
... full annual review of 2005, here's a quick recap of ... we'll expand our scope and republish some of our best ... , Stem cells , ,They could be called Wisconsin's ... here outside of the University of Wisconsin work with stem ...
... three Medical College of Wisconsin radiology professors could help ... received FDA clearance last week to market the software ... ,Kyron's software would interpret the data from a magnetic ... by the company showed that it could present several ...
Cached Biology Technology:UW biotech program launches graduates into evolving industry (part 2) 2UW biotech program launches graduates into evolving industry (part 2) 3Stem-cell debate, wireless access and other endeavors heat up 2Stem-cell debate, wireless access and other endeavors heat up 3Stem-cell debate, wireless access and other endeavors heat up 4
... Model SPD131DDA , Our most chemically resistant ... to handle the rigors and solvents of Combinatorial ... display, dual independent timers, an automatic bleeder valve ... pathway. , , Adjustable Vacuum Level ...
... a dedicated concentrator for efficient drying of ... The integrated system combines the SpeedVac™ Concentrator ... design, automatic pump and rotor control, and ... for heater time), makes the DNA120 indispensable ...
... George Paxinos Affiliation: School of Psychology, The ... Watson Affiliation: Curtin University of Technology, Perth, Australia ... atlas of the rat brain. It is ... mm) revison and extension of the compact 3rd ...
For absolute protein quantification. 4 peptides in 5 vials x 2 nmol per peptide...
Biology Products: