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Mathematical and biochemical 'design features' for cell decoding of pulses revealed
Date:3/13/2014

t of the biology, where GnRH receptor number and GnRH pulse interval vary, for example, through puberty and through the menstrual cycle.

"These features are relevant to numerous biological systems using pulsatile stimuli and suggest intriguing mechanisms for differential control of rapid and delayed responses with dynamic stimuli."

Professor Krasimira Tsaneva-Atanasova, Associate Professor of Mathematics at the University of Exeter and co-author on the paper said: "The effects of a signalling molecule can be fast or slow and the same signalling molecule will often elicit a rapid, transient response from a cell followed by a slower, long term change in cell behaviour.

"How fast and slow molecular pathways are modulated by pulsatile, or dynamic, inputs is particularly important for understanding GnRH signalling in physiologically relevant stimulation paradigms and identifying new tools that could be used for fertility control and treatment of hormone-dependent cancer."

Billions are spent every year on GnRH receptor ligands and the stimulation paradigm is absolutely crucial for therapeutic applications, but remarkably little is known about how the target cells and tissues decode GnRH dynamics.

The work is strengthened by the collaboration between the University's School of Clinical Sciences and School of Mathematics together with the Department of Maths at the University of Exeter, and the study illustrates the additional insight to be gained from such collaborative "maths-driven biology".


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Contact: Joanne Fryer
press-office@bristol.ac.uk
44-117-331-7276
University of Bristol
Source:Eurekalert

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