Navigation Links
Math models enhance current therapies for coronary heart disease
Date:12/9/2013

Coronary heart disease accounts for 18% of deaths in the United States every year. The disease results from a blockage of one or more arteries that supply blood to the heart muscle. This occurs as a result of a complex inflammatory condition called artherosclerosis, which leads to progressive buildup of fatty plaque near the surface of the arterial wall.

In a paper published last month in the SIAM Journal on Applied Mathematics, authors Sean McGinty, Sean McKee, Roger Wadsworth, and Christopher McCormick devise a mathematical model to improve currently-employed treatments of coronary heart disease (CHD).

"CHD remains the leading global cause of death, and mathematical modeling has a crucial role to play in the development of practical and effective treatments for this disease," says lead author Sean McGinty. "The use of mathematics allows often highly complex biological processes and treatment responses to be simplified and written in terms of equations which describe the key parameters of the system. The solution of these equations invariably provides invaluable insight and understanding that will be crucial to the development of better treatments for patients in the future."

The accumulation of plaque during CHD can result in chest pain, and ultimately, rupture of the artherosclerotic plaque, which causes blood clots blocking the artery and leading to heart attacks. A common method of treatment involves inserting a small metallic cage called a stent into the occluded artery to maintain blood flow.

However, upon insertion of a stent, the endotheliumthe thin layer of cells that lines the inner surface of the arterycan be severely damaged. The inflammatory response triggered as a result of this damage leads to excessive proliferation and migration of smooth muscle cells (cells in the arterial wall that are involved in physiology and pathology) leading to re-blocking of the artery. This is an important limitation
'/>"/>

Contact: Karthika Muthukumaraswamy
karthika@siam.org
267-350-6383
Society for Industrial and Applied Mathematics
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New book on mouse models of cancer from Cold Spring Harbor Laboratory Press
2. NYSCF and NIH create cell models of rare and undiagnosed diseases
3. Elevated levels of copper in amyloid plaques associated with neurodegeneration in mouse models of AD
4. New knowledge about permafrost improving climate models
5. New agent inhibits HCV replication in mouse models -- No resistance seen
6. Large animal models of Huntingtons disease offer new and promising research options
7. AACR news: Paragazole excels in preclinical models of triple-negative breast cancer
8. Cleverly designed vaccine blocks H5 avian influenza in models
9. Pig brain models provide insights into human cognitive development
10. Engineering control theory helps create dynamic brain models
11. Mentoring models to move minorities to majorities in STEM
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Math models enhance current therapies for coronary heart disease
(Date:12/17/2014)... , Dec. 16, 2014  Automation is fundamentally ... more evident than at international borders. Over the ... scanners have allowed veteran travelers to self process ... Control (APC) Kiosks at an increasing number of ... According to Maxine Most ...
(Date:12/11/2014)... 2014  Data Sciences International (DSI), the global ... new series of digital telemetry implants to meet ... series, part of the PhysioTel™ Digital platform, was ... physiologic data when incorporating functional endpoints into repeat-dose ... toxicology studies has evolved from short ECG strips ...
(Date:12/10/2014)... Dec. 08, 2014 Research and Markets ... of the "Biometrics Market in Japan 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 The integration ... as rural banking and upgradation of the driver,s ... in the market. Besides the aforementioned projects, biometrics ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... study by Nanyang Technological University (NTU),s Assistant Professor Li ... team have made an important contribution to the understanding ... die. This process known as ,apoptosis, or programmed cell ... which removes perhaps a million cells a second. ...
... Nanostructured materials have garnered great interest worldwide due ... structural, medical and consumer applications. Singapore,s ... a new environmentally friendly method to synthesize a ... synthesis has been recently published in Nature ...
... (NOAA) today published a final rule in the Federal Register ... (EEZ) off the coasts of California, Oregon, and Washington. ... Krill are a small shrimp-like crustacean and a key ... are the foundation for a healthy marine ecosystem," said Mark ...
Cached Biology News:Study by NTU professors provides important insight into apoptosis or programmed cell death 2Facile synthesis of nanoparticles with multiple functions advanced in Singapore 2NOAA bans commercial harvesting of krill 2
(Date:12/24/2014)... -- Rock Creek Pharmaceuticals, Inc., (NASDAQ: RCPI ) ... Application (CTA) with the United Kingdom,s ... approval to initiate clinical trials for the continued development ... on the Company receiving CTA regulatory approval, the Company ... the safety, tolerability and dose escalation of Anatabine Citrate ...
(Date:12/22/2014)... N.C. , Dec. 22, 2014  Alternative ... announced that it has signed a letter of ... that has developed and patented a nanotechnology-based development ... diagnostics products that enable rapid on-site collection and ... use/abuse and health issues in an immediate, non-invasive ...
(Date:12/22/2014)... Fertility Associates of Memphis has announced a new ... network of more than 20 contributing fertility practices ... access to a national pool of frozen donor ... of Memphis is the only fertility clinic in the ... Dr. William Kutteh , director of Fertility Associates of ...
(Date:12/19/2014)... PLEASANTON, Calif. , Dec. 19, 2014  Roche ... acquisition of Bina Technologies, Inc. (Bina), a privately ... California , USA. Bina provides a big ... next generation sequencing (NGS) data. Bina,s proprietary on-market ... translational and academic researchers to perform fast and ...
Breaking Biology Technology:Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3ALNE Announces Intention To Acquire BioTechPharma 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3
... and Funding Barriers and Paves Way ... for Affordable and Efficient Approach, KAKAMEGA, Kenya, ... and HIV was launched today in the Western,Kenyan district of ... a basic care package consisting of a,PermaNet(R) long-lasting insecticide-treated bed ...
... Institutional Investors to Attend Conference, MONTREAL, Sept. ... today announced that Mr. Pierre Laurin, President,and Chief ... 5th,annual Investor Summit on September 16, 2008 at ... Mark Hopkins InterContinental Hotel in San Francisco., ...
... Calif., Sept. 12 Acologix, Inc., a privately,held ... studies demonstrating that AC-100, its therapeutic product,candidate derived ... and,dental cells, promotes cartilage regeneration in large animal ... A. Middleton-Hardie on September,13, 2008 at the 30th ...
Cached Biology Technology:Integrated Prevention Demonstration Campaign Launched in Western Kenya to Fight HIV, Malaria and Diarrhoeal Disease 2Integrated Prevention Demonstration Campaign Launched in Western Kenya to Fight HIV, Malaria and Diarrhoeal Disease 3ProMetic to present at Merriman Curhan Ford's Investor Summit 2008 on September 16th 2Acologix Presents Preclinical Data on Cartilage Regeneration by AC-100 at the 30th ASBMR Annual Meeting 2Acologix Presents Preclinical Data on Cartilage Regeneration by AC-100 at the 30th ASBMR Annual Meeting 3
... next step in the evolution of laboratory ... that delivers labware to multiple laboratory instruments, ... the throughput of ordinary microplate robots. It ... of configurations to meet any labs specific ...
... applications for the use of small interfering ... via the RNA interference (RNAi) pathway have ... molecular biology fields. siRNA for experimental use ... or enzymatically, and then transfected into the ...
... S&S Custom Array Service enables scientists who have ... to have FAST Slides printed with proteins from ... Processing of the arrays is performed by the ... S&S to discuss your needs with an expert ...
... The high-performance triple quadrupole 1200L ... in today's cost-conscious environment - incorporating ... solutions for all liquid chromatography analytical ... (API) interface and the Transmission Quadrupole ...
Biology Products: