Navigation Links
Maternal diet and genes interact to affect heart development
Date:7/6/2010

it is the combination of high fat diet and the genetic defect that is responsible.

The researchers showed that high fat diet and Cited2 deficiency interacted by reducing the expression of another gene called Pitx2. This latter gene is also necessary for heart development and the body's natural asymmetry.

"These are very important findings as we have been able to show for the first time that gene-environment interactions can affect development of the embryo in the womb," says Dr Jamie Bentham, first author of the study.

"We know that poor diet and defective genes can both affect development, but here we have seen the two combine to cause a much greater risk of developing health problems and more severe problems. We are excited by this as it suggests that congenital heart defects may be preventable by measures such as altering maternal diet."

"There is a growing amount of research which suggests that a mother's diet can have a long term impact on the health of her offspring," says BHF Professor Shoumo Bhattacharya. "This is concerning when we also consider the increasing problem of obesity in women of reproductive age. A healthy, balanced diet is important at all times, but our research shows that this is particularly true during pregnancy when diet can potentially affect both the mother and her child."

Professor Jeremy Pearson, Associate Medical Director of the BHF, which part-funded the study, said:

"This research shows that diet during pregnancy can directly affect which genes get switched on in unborn offspring. The study was with mice, but a similar link may exist in humans, leading to some cases of congenital heart disease.

"We already know that if pregnant women lack certain nutrients in the diet, such as folic acid, it can lead to abnormal development in the baby, so it's not surprising that eating too much of something can also cause problems.

"The findings suggest it's wise for preg
'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Wasp genetics study suggests altruism evolved from maternal behavior
2. Evolutionary biology research on plant shows significance of maternal effects
3. Family ties that bind: Maternal grandparents are more involved in the lives of their grandchildren
4. Egg P bodies protect maternal gene messages
5. Researchers block damage to fetal brain following maternal alcohol consumption
6. Exposing chicks to maternal stress leads to long-term reproductive success
7. New technology aims to reduce maternal and neonatal deaths
8. Maternal health problems in Myanmar widespread
9. Effects of maternal exercise on fetal breathing movements
10. Effects of maternal exercise on fetal breathing movements
11. Lack of happiness hormone serotonin in the brain causes impaired maternal behavior in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces it has ... for the 2015 International CES debut of the Wocket™ ... will be at the NXT-ID booth January 6th and 7 ...
(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ( ... "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire ... http://photos.prnewswire.com/prnh/20130307/600769 Following ... the fingerprint reading feature with the iPhone 5S. It ...
(Date:12/19/2014)... , Dec. 18, 2014   LaunchKey , the first ... post-password and Internet of Things era, today announced the ... venture round was led by Metamorphic Ventures with participation ... Partners, VegasTechFund, and others.  LaunchKey has raised $4 million ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... modeling and paleontological evidence as a crystal ball, 18 ... on a much worse collision course with Mother Nature ... state-shift in Earth,s biosphere, a paper just published in ... multitude of disciplines, suggest our planet,s ecosystems are careening ...
... that live zebrafish can be influenced by engineered robots. ... Bioinspiration and Biomimetics , provide a stepping stone on the ... monitor and control fish behaviour. In the future, water-based ... and the control of pest species. ...
... Researchers who were looking for organisms that eke out ... Earth have found a hardy few. A new DNA analysis ... in South America has revealed a handful of bacteria, fungi, ... a different way of converting energy than their cousins elsewhere ...
Cached Biology News:Study predicts imminent irreversible planetary collapse 2Engineered robot interacts with live fish 2AGU: Unique microbes found in extreme environment 2AGU: Unique microbes found in extreme environment 3AGU: Unique microbes found in extreme environment 4
(Date:1/22/2015)... (PRWEB) January 22, 2015 Dr. Greg Leyer ... 12th annual Scripps Natural Supplements Pre-Conference seminar on probiotics in ... is an annual continuing education conference for health care professionals. ... included the topic of probiotics in health. Dr. Leyer spoke ...
(Date:1/22/2015)... BRUNSWICK , Nueva Jersey , 22 de ... Award for Biomedical Research abre hoy su llamada a ... personas cuya investigación científica ha hecho, o tiene el ... la salud humana. Las nominaciones se aceptarán hasta el ...
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. (Nasdaq: ... focused on advanced wound care, announces that AMNIOEXCEL® ... have been added to the Premier, Inc. Regenerative ... opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product lines, ...
(Date:12/24/2014)... Texas , Dec. 24, 2014  Vermillion, Inc. ... on gynecologic disease, announced today that the Company ... including Oracle Investment Management, Jack W. Schuler ... Total proceeds were $10.5 million, before offering expenses.  ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... 2008 at 1:30 p.m. (Pacific); ... at http://www.adventrx.com , SAN DIEGO, March 6 ADVENTRX ... a conference call and,webcast on Thursday, March 13th, 2008 at 1:30 ... end 2007 results. Evan M.,Levine, chief executive officer and president of ...
... release is available in German . ... closeon command. Researchers led by Ahmed H. Zewail successfully ... at their exercises, as they report in the journal ... future nanoelectronics and nanoscopic machines. , Zewail and ...
... March 5 Vaccinex, Inc. announced today,that Dr. ... Board, and will,be actively involved in the strategic ... programs., Dr. Leonard has over 20 years ... Senior Director level positions in Regulatory Affairs, Quality,Project ...
Cached Biology Technology:Nanoswitches toggled by light 2John E. Leonard, Ph.D., Former Biogen Idec Antibody Development Executive, Joins the Scientific Advisory Board of Vaccinex, Inc. 2
... Cell Whole Genome Amplification Kit utilizes ... fragmentation of genomic DNA and conversion ... PCR-amplifiable library molecules flanked by universal ... PCR amplification of the library molecules ...
...
From formula-fed bovine calves Sterile, Cell culture tested...
Collected at a certified USDA establishment located within the United States. All final processing is done by Quad Five employees....
Biology Products: