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Maternal, paternal genes' tug-of-war may last well into childhood
Date:7/28/2009

CAMBRIDGE, Mass., July 28, 2009 -- An analysis of rare genetic disorders in which children lack some genes from one parent suggests that maternal and paternal genes engage in a subtle tug-of-war well into childhood, and possibly as late as the onset of puberty.

This striking new variety of intra-family conflict, described this week in the Proceedings of the National Academy of Sciences, is the latest wrinkle in the two-decades-old theory known as genomic imprinting, which holds that each parent contributes genes that seek to nudge his or her children's development in a direction most favorable, and least costly, to that parent.

"Compared to other primates, human babies are weaned quite early, yet take a very long time to reach full nutritional independence and sexual maturity," says author David Haig, George Putnam Professor of Organismic and Evolutionary Biology in Harvard University's Faculty of Arts and Sciences. "Human mothers are also unusual among primates in that they often care for more than one child at a time. Evidence from disorders of genomic imprinting suggests that maternal and paternal genes may skirmish over the pace of human development."

Previous research has offered evidence of a genetic struggle for supremacy only during fetal development: In the womb, some genes of paternal origin have been shown to promote increased demands on mothers, leading to fetal overgrowth, while genes of maternal origin tend to have the opposite effect. This new work suggests maternal and paternal genes continue to engage in internal genetic conflict past childbirth.

"This analysis suggests that human life history, and especially humans' unusual extended childhood, may reflect a compromise between what's best for mothers, fathers, and the offspring themselves," Haig says.

Haig delved into clinical case reports on patients with four rare genetic disorders. He found evidence that children with disorders characterize
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Contact: Steve Bradt
steve_bradt@harvard.edu
617-496-8070
Harvard University
Source:Eurekalert

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