Navigation Links
Maternal, paternal genes' tug-of-war may last well into childhood
Date:7/28/2009

CAMBRIDGE, Mass., July 28, 2009 -- An analysis of rare genetic disorders in which children lack some genes from one parent suggests that maternal and paternal genes engage in a subtle tug-of-war well into childhood, and possibly as late as the onset of puberty.

This striking new variety of intra-family conflict, described this week in the Proceedings of the National Academy of Sciences, is the latest wrinkle in the two-decades-old theory known as genomic imprinting, which holds that each parent contributes genes that seek to nudge his or her children's development in a direction most favorable, and least costly, to that parent.

"Compared to other primates, human babies are weaned quite early, yet take a very long time to reach full nutritional independence and sexual maturity," says author David Haig, George Putnam Professor of Organismic and Evolutionary Biology in Harvard University's Faculty of Arts and Sciences. "Human mothers are also unusual among primates in that they often care for more than one child at a time. Evidence from disorders of genomic imprinting suggests that maternal and paternal genes may skirmish over the pace of human development."

Previous research has offered evidence of a genetic struggle for supremacy only during fetal development: In the womb, some genes of paternal origin have been shown to promote increased demands on mothers, leading to fetal overgrowth, while genes of maternal origin tend to have the opposite effect. This new work suggests maternal and paternal genes continue to engage in internal genetic conflict past childbirth.

"This analysis suggests that human life history, and especially humans' unusual extended childhood, may reflect a compromise between what's best for mothers, fathers, and the offspring themselves," Haig says.

Haig delved into clinical case reports on patients with four rare genetic disorders. He found evidence that children with disorders characterize
'/>"/>

Contact: Steve Bradt
steve_bradt@harvard.edu
617-496-8070
Harvard University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gene regulation, not just genes, is what sets humans apart
2. Interaction of just 2 genes governs coloration patterns in mice
3. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
4. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
5. Smoking turns on genes -- permanently
6. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
7. Hebrew SeniorLife researchers search for aging, osteoporosis genes
8. UT Southwestern researchers identify hundreds of genes controlling female fertility
9. Genes and environment grant funds close look at nature-nurture overlap in common diseases
10. Jumping genes could make for safer gene delivery system
11. Genes from the father facilitate the formation of new species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... , April 2, 2015 Fingerprint ... fingerprint sensor FPC1025 from the distributor World Peace Industrial ... during Q2 2015 although the major part of the ... will be used by smartphone manufacturers in ... is included in the communicated revenue guidance of + ...
(Date:3/30/2015)... Mar. 26, 2015 Research and Markets ... "Global Gesture Recognition Market in Automotive Sector 2014-2018" ... forecast the Global Gesture Recognition market in Automotive Sector ... period 2013-2018. Gesture recognition is the ability ... gestures of an individual. Gesture recognition technology can be ...
(Date:3/24/2015)... GARDENS, Fla. , March 24, 2015 /PRNewswire/ ... identity management solutions, today announced that its U.are.U ... clothing accessory retailer Goorin Bros . to ... Crossmatch biometrics-based solution secures access to the POS ... the increased risk of data breaches. ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2
... Clough has developed a novel method for eavesdropping ... bursts. The doctoral student at Rensselaer Polytechnic Institute ... waves to boost the distance from which researchers ... hidden explosives, chemicals, and other dangerous materials. ...
... Ever get a flu shot and still get the flu? If ... come thanks to a new discovery by researchers who found that ... ability of flu vaccines to ward off this deadly virus. A ... Journal of Leukocyte Biology ( http://www.jleukbio.org ) suggests that ...
... why primates differ from other mammals, and humans differ from ... genome that were once considered "junk." A new study ... Medicine finds that when a particular type of repetitive DNA ... genes, they can alter the rate at which proteins are ...
Cached Biology News:Student innovation at Rensselaer holds key to safer remote detection of dangerous materials 2Student innovation at Rensselaer holds key to safer remote detection of dangerous materials 3Drug to fight tumors also fights the flu and possibly other viruses 2U. Iowa team investigates function of 'junk DNA' in human genes 2U. Iowa team investigates function of 'junk DNA' in human genes 3
(Date:4/27/2015)... 27, 2015 Elsevier , a ... services, and Qatar University Research Office   have announced the ... The awards ceremony, held last week at ... attended by more than 40 guests representing Qatar,s ... by Professor Sheikha Abdulla Al-Misnad , President of ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 Leading ... milestones in its allogeneic stem-cell product development program ... properly reflect the corporate strategic direction. , “I ... (donor) adipose stem cell development program has been ... our cGMP manufacturing facility and hiring of our ...
(Date:4/24/2015)... , April 24, 2015 /CNW Telbec/ - Mirego, leader in ... the making of three mobile app extensions for the all ... for its clients, Familiprix, OMSignal and MediaMiser, these extensions will ... to functions designed specifically for wrist use.  ... Watch is a highly customizable tactile smartwatch that makes for ...
(Date:4/23/2015)... 24, 2015 Ralco announced today that ... Nutrition® (ABN) for the exclusive worldwide rights to sell ... technology is a new in-line milk system that increases ... them to move supplementation milk cups within a farrowing ... “This technology lets producers get Birthright™ milk to the ...
Breaking Biology Technology:Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 2Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 3Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 4Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 5Vet-Stem, Inc. Meets New Milestones and Changes Name to VetStem Biopharma 2Familiprix, OMSignal and MediaMiser apps available today for Apple Watch 2Ralco Acquires License to Birthright™ Moveable Milk Cup 2
... Both recombinant human , ... vitro to cleave long dsRNA, producing siRNA cocktails that are , ... (1-6). Dicer is an , ... enzyme responsible for cleavage of long dsRNAs to siRNA in the , ...
... Gene Specific siRNA Controls , ... research or you are an siRNA expert, ... the Silencer gene specific siRNA , ... contains 50 g of ready-to-use chemically synthesized and gel , ...
... siRNA designs now available , ... , ... highly effective siRNAs , High quality custom siRNA synthesis from The RNA Company ... choice of synthesis options , Premium ...
Cached Biology Technology:Dicer vs. RNase III for Preparation of siRNA Cocktails 2Dicer vs. RNase III for Preparation of siRNA Cocktails 3Control Your siRNA Research 2Control Your siRNA Research 3Cenix-Designed siRNAs for 95% of Human and Mouse Genomes 2Cenix-Designed siRNAs for 95% of Human and Mouse Genomes 3Cenix-Designed siRNAs for 95% of Human and Mouse Genomes 4Cenix-Designed siRNAs for 95% of Human and Mouse Genomes 5Cenix-Designed siRNAs for 95% of Human and Mouse Genomes 6
... (10 min) assay can detect H2O2 or ... (ADHP). H2O2 oxidizes ADHP in a 1:1 ... (excitation at 530-571 nm, emission at 590-600 ... in a one-step, homogeneous, no wash assay ...
... Description: ,Kit containing Dermal Fibroblasts ... supplied as a long-term culture, and is ... of continuous growth from the date supplied, ... ,Source: Dermis, mouse/BalbC, embryonic day 18.5 ...
... ABsolute QRT-PCR Mixes are formulated for ... primers and SYBR Green. One-step QRT-PCR mixes ... analysing RNA. The pipetting steps are minimised, ... automation possible. ,The 2x ABsolute QRT-PCR Mix ...
... for protein pull-down experiments to ... proteins. An order of Sphingobeads ... beads with 10 nmol of ... of the alkyl chain; enough ...
Biology Products: