Navigation Links
Material screening method allows more precise control over stem cells
Date:4/11/2013

MADISON When it comes to delivering genes to living human tissue, the odds of success come down the molecule. The entire therapy including the tools used to bring new genetic material into a cell must have predictable effects.

Now, a new screening process will simplify non-viral transfection, providing a method researchers and clinicians use to find an optimal set of biomaterials to deliver genes to cells.

Developed by William Murphy, the Harvey D. Spangler professor of biomedical engineering at the University of Wisconsin-Madison, the method gives researchers greater control over how cells react to the gene delivery mechanism. The broader implication is more nuanced, effective control over cell behavior. "We've been exploring using this concept for reprogramming of adult cells, as well as controlling differentiation of stem cell types," Murphy says.

Murphy and his collaborators published news of their advance in the March 28, 2013 issue of Nature Scientific Reports. http://www.nature.com/srep/2013/130328/srep01567/full/srep01567.html

In a current successful approach, researchers use specialized viruses to deliver genetic material to cells. While efficient, that method also carries a greater risk of turning on unwanted genes or provoking an immune response from the body making it less attractive for sensitive biomedical applications like controlling stem cell behavior, says Murphy.

His team has developed a process that does not rely on viruses. Rather, the researchers can grow specific calcium phosphate coatings that serve as a medium via which genetic material can be delivered to cells more efficiently. By matching a coating to a specific application for delivering genes, Murphy has seen up to a 70-fold increase in successful expression of those genes in human stem cells.

"From an application standpoint, the advance could be really impactful, and could enable gene delivery to become an integral part of medical device design and tissue engineering applications," says Murphy.

The process could be critical to further advances in regenerative medicine. Since researchers can apply it to any size or shape of tissue engineering structure, it could help provide engineers a simpler way to build the complex tissue structures required to deliver next-generation drug screening and patient therapies.


'/>"/>

Contact: William Murphy
wlmurphy@wisc.edu
608-262-2224
University of Wisconsin-Madison
Source:Eurekalert

Related biology news :

1. Researchers discover brain cancer treatment using genetic material from bone marrow cells
2. Market Analysis: Biomaterials and Engineered Protein
3. NTU scientist develops a multi-purpose wonder material to tackle enviromental challenges
4. Renewed Harvard-BASF initiative to advance functional materials
5. Painting with catalysts: Nano-engineered materials for detoxifying water by use of sunlight
6. Nanomaterials key to developing stronger artificial hearts
7. Pact invests US $109 million to secure critical genetic material, maintain global food production
8. UGA researchers invent new material for warm-white LEDs
9. Oscillating gel gives synthetic materials the ability to speak
10. Stem cell materials could boost research into key diseases
11. Synthetic and biological nanoparticles combined to produce new metamaterials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2016)... "The biometric system market ... The biometric system market is in the growth stage ... future. The biometric system market is expected to be ... CAGR of 16.79% between 2016 and 2022. Government initiative ... in smartphones, rising use of biometric technology in financial ...
(Date:11/19/2016)... 18, 2016 Securus Technologies, a leading provider ... safety, investigation, corrections and monitoring, announced today that it ... to have an independent technology judge determine who has ... high tech/sophisticated telephone calling platform, and the best customer ... do most of what we do – which clearly ...
(Date:11/15/2016)... -- Research and Markets has announced the addition of ... to their offering. ... The global bioinformatics ... USD 6.21 Billion in 2016, growing at a CAGR of 21.1% ... market is driven by the growing demand for nucleic acid and ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... SAN DIEGO , Dec. 8, 2016 /PRNewswire-USNewswire/ ... treatments for congestive heart failure and type 2 ... license for a novel adeno-associated virus (AAV) vector ... Kay , M.D., Ph.D., at Stanford University. The ... of its paracrine gene therapy product pipeline. ...
(Date:12/8/2016)... England , December 8, 2016 ... das Unternehmen für Molekulargenetik, erweitert seine Palette an ... myPanel™ NGS Custom FH Panels, das ein schnelles ... (FH) ermöglicht. Das Panel bietet eine Erkennung von ... Variations (CNV) mit einem einzigen kleinen Panel und ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... their exceptionally efficient human mesenchymal stem/stromal cell (hMSC) expansion medium. This ... products engineered to radically streamline culture processes, minimize processing time, significantly decrease ...
(Date:12/8/2016)... Dec. 8, 2016 Soligenix, Inc. (OTCQB: SNGX) ... on developing and commercializing products to treat rare diseases ... that it will be hosting an Investor Webcast Event ... the origins of innate defense regulators (IDRs) as a ... oral mucositis and the recently announced and published Phase ...
Breaking Biology Technology: