Navigation Links
Material screening method allows more precise control over stem cells
Date:4/11/2013

MADISON When it comes to delivering genes to living human tissue, the odds of success come down the molecule. The entire therapy including the tools used to bring new genetic material into a cell must have predictable effects.

Now, a new screening process will simplify non-viral transfection, providing a method researchers and clinicians use to find an optimal set of biomaterials to deliver genes to cells.

Developed by William Murphy, the Harvey D. Spangler professor of biomedical engineering at the University of Wisconsin-Madison, the method gives researchers greater control over how cells react to the gene delivery mechanism. The broader implication is more nuanced, effective control over cell behavior. "We've been exploring using this concept for reprogramming of adult cells, as well as controlling differentiation of stem cell types," Murphy says.

Murphy and his collaborators published news of their advance in the March 28, 2013 issue of Nature Scientific Reports. http://www.nature.com/srep/2013/130328/srep01567/full/srep01567.html

In a current successful approach, researchers use specialized viruses to deliver genetic material to cells. While efficient, that method also carries a greater risk of turning on unwanted genes or provoking an immune response from the body making it less attractive for sensitive biomedical applications like controlling stem cell behavior, says Murphy.

His team has developed a process that does not rely on viruses. Rather, the researchers can grow specific calcium phosphate coatings that serve as a medium via which genetic material can be delivered to cells more efficiently. By matching a coating to a specific application for delivering genes, Murphy has seen up to a 70-fold increase in successful expression of those genes in human stem cells.

"From an applicati
'/>"/>

Contact: William Murphy
wlmurphy@wisc.edu
608-262-2224
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover brain cancer treatment using genetic material from bone marrow cells
2. Market Analysis: Biomaterials and Engineered Protein
3. NTU scientist develops a multi-purpose wonder material to tackle enviromental challenges
4. Renewed Harvard-BASF initiative to advance functional materials
5. Painting with catalysts: Nano-engineered materials for detoxifying water by use of sunlight
6. Nanomaterials key to developing stronger artificial hearts
7. Pact invests US $109 million to secure critical genetic material, maintain global food production
8. UGA researchers invent new material for warm-white LEDs
9. Oscillating gel gives synthetic materials the ability to speak
10. Stem cell materials could boost research into key diseases
11. Synthetic and biological nanoparticles combined to produce new metamaterials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... Axinaea belongs to the large, mainly tropical flowering plant ... species in the family rely on bees for their pollination. ... insects or vertebrates. The flowers of Axinaea appear ... the petals of the different species are pink, yellow, orange ... on the contrasting colours of their bulbous appendages. The pollination ...
(Date:7/10/2014)... ocean as a microbial megacity, teeming with life too ... hundreds of types of bacteria can be found. ... microbes have their own daily cyclesnot unlike the residents ... commute, work, and eat at the same times., What,s ... that need solar energy to help them photosynthesize food ...
(Date:7/10/2014)... Endomedix, a start-up company housed at NJIT,s business incubator, ... spray-on gel that surgeons will use to staunch bleeding ... onto a surgical site, and the natural bio-polymer solutions ... the patient within 30 seconds. , The gel ... It will translate into less time for the patient,s ...
Breaking Biology News(10 mins):Novel type of bird pollination mechanism discovered in South America 2New research finds ocean's most abundant organisms have clear daily cycles 2New research finds ocean's most abundant organisms have clear daily cycles 3A start-up at NJIT develops bleeding-control gel for brain surgery 2
... Drug Administration (FDA) today issued a public health advisory ... to new safety information concerning an unapproved (i.e., "off-label") ... drugs are approved for the treatment of schizophrenia and ... behavioral disorders in elderly patients with dementia have shown ...
... versatile microorganisms ?a bacterium called Pseudomonas putida ?could ... the destruction of the chemical weapon mustard, write ... Biotechnology (http://www.interscience.wiley.com/jctb) this month. , At 40,000 tonnes, ... warfare agents (CWAs). The country faces a race ...
... traveler's diarrhea cases among U.S. travelers to Mexico ... cause of nonbacterial gastroenteritis outbreaks usually associated with ... researchers at the Johns Hopkins Bloomberg School of ... found that the longer travelers stayed at their ...
Cached Biology News:FDA Warns About Antipsychotic Drugs and Elderly 2Could microbes solve Russia's chemical weapons conundrum? 2Norovirus found to cause traveler's diarrhea 2
(Date:7/10/2014)... quantum Hall effect in bilayer graphene and shown that ... an electric field. , The fractional quantum Hall ... sheets are exposed to large magnetic fields, is a ... electrons behave as a single system. However, while the ... details of this collective behavior remain not well understood, ...
(Date:7/10/2014)... recent study by researchers at the University of ... physical mechanisms governing the interplay of spin and ... limits of ultrafast spintronic devices for data storage ... charge as well as spin-angular momentum. In a ... there is no spin current," explained David Cahill, ...
(Date:1/15/2014)... , Jan. 15, 2014  Bill Jacobs Automotive, a group of ... teaming up with the Heartland Blood Center and offering free ... The drive takes place Saturday, Jan. 18 at the Bill ... p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... Cynvenio, a cancer diagnostics company focused ... analysis of tumor cells in the bloodstream, today announced ... decision support application powered by CollabRx, Inc. , ... test, Therapy Finder will provide breast cancer patients and ...
Breaking Biology Technology:Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3University of Illinois study advances limits for ultrafast nano-devices 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3
... A friend of mine at a small college once threw a ... the evening, my friends 10-year old daughter was presented and asked ... was Aren-kay Iller-may, sure that her recently learned pig Latin was ... As a consultant who sees a lot of interactions between technologists ...
... health will address how IT can be leveraged to improve ... the nation in this effort. , ,MADISON - The ... of data lead to as many as 100,000 deaths each ... Network will host their 2nd Annual Digital Healthcare Conference ...
... University of Wisconsin-Madison Department of Educational Psychology has teamed ... Learning Co-Lab to create new worlds in which ... ,"The Department's Learning Sciences Program studies how ... professor in UW-Madison's School of Education. "We have made ...
Cached Biology Technology:Echnology-tay Eak-spay 2Echnology-tay Eak-spay 3Wisconsin Technology Network presents symposium on saving lives by the use of Information Technology 2Wisconsin Technology Network presents symposium on saving lives by the use of Information Technology 3University of Wisconsin team creates learning games 2University of Wisconsin team creates learning games 3
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ...
... its effects by binding ... a disulfide-linked heterotetrameric protein ... subunits and two Beta ... following configuration: Beta-Alpha-Alpha-Beta. ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. Mfr ...
... 11, Compliant software for JASCO HPLC systems. , Integrated Instrument ... EZChrom Elite ... options for JASCO HPLC systems. This provides a completely integrated system ... settings with each run. , ...
Biology Products: