Navigation Links
Material screening method allows more precise control over stem cells
Date:4/11/2013

MADISON When it comes to delivering genes to living human tissue, the odds of success come down the molecule. The entire therapy including the tools used to bring new genetic material into a cell must have predictable effects.

Now, a new screening process will simplify non-viral transfection, providing a method researchers and clinicians use to find an optimal set of biomaterials to deliver genes to cells.

Developed by William Murphy, the Harvey D. Spangler professor of biomedical engineering at the University of Wisconsin-Madison, the method gives researchers greater control over how cells react to the gene delivery mechanism. The broader implication is more nuanced, effective control over cell behavior. "We've been exploring using this concept for reprogramming of adult cells, as well as controlling differentiation of stem cell types," Murphy says.

Murphy and his collaborators published news of their advance in the March 28, 2013 issue of Nature Scientific Reports. http://www.nature.com/srep/2013/130328/srep01567/full/srep01567.html

In a current successful approach, researchers use specialized viruses to deliver genetic material to cells. While efficient, that method also carries a greater risk of turning on unwanted genes or provoking an immune response from the body making it less attractive for sensitive biomedical applications like controlling stem cell behavior, says Murphy.

His team has developed a process that does not rely on viruses. Rather, the researchers can grow specific calcium phosphate coatings that serve as a medium via which genetic material can be delivered to cells more efficiently. By matching a coating to a specific application for delivering genes, Murphy has seen up to a 70-fold increase in successful expression of those genes in human stem cells.

"From an applicati
'/>"/>

Contact: William Murphy
wlmurphy@wisc.edu
608-262-2224
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover brain cancer treatment using genetic material from bone marrow cells
2. Market Analysis: Biomaterials and Engineered Protein
3. NTU scientist develops a multi-purpose wonder material to tackle enviromental challenges
4. Renewed Harvard-BASF initiative to advance functional materials
5. Painting with catalysts: Nano-engineered materials for detoxifying water by use of sunlight
6. Nanomaterials key to developing stronger artificial hearts
7. Pact invests US $109 million to secure critical genetic material, maintain global food production
8. UGA researchers invent new material for warm-white LEDs
9. Oscillating gel gives synthetic materials the ability to speak
10. Stem cell materials could boost research into key diseases
11. Synthetic and biological nanoparticles combined to produce new metamaterials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2015)... CLARA, Calif. , Aug. 20, 2015 /PRNewswire/ ... company focused on improving the user experience and ... and vision technologies, today announced that its ... voice biometric authentication software to be FIDO ... tested TrulySecure for compliance with the FIDO UAF ...
(Date:8/17/2015)... OXFORD, Conn. , Aug. 17, 2015  NXT-ID, ... a biometric authentication company focused on the growing mobile ... announces its new sales campaign for Q4 2015. The ... winning marketing team consisting of Amplitude Marketing Group ( ... Amplitude Marketing Group is a leader in retail driven ...
(Date:8/11/2015)... , August 11, 2015 Today, ZUK ... Already received as well as expected revenues in 2015 that relate ... FPC,s communicated revenue guidance of approximately 2,200 MSEK for 2015. ... is a prominent smartphone manufacturer in ... ZUK selected FPC1 155 for ...
Breaking Biology News(10 mins):TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2
... of immune cell DNA in the blood could help ... will successfully restore a population of infection-fighting cells called ... at St. Jude Children's Research Hospital, is published in ... predict whether children receiving such a transplant will experience ...
... causing severe acute respiratory syndrome (SARS) may spread through the ... as previous research had shown. , SARS coronavirus was detected ... outbreak in Toronto, according to a new study published in ... shows patients in hospital bays near a SARS patient had ...
... succeeded in discovering and isolating a new protein,from ... that could have consequences for development of future,nanocapsules ... being obtained from plant tissue, the protein can ... recombinant protein in,bacteria, making it highly available for ...
Cached Biology News:Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation 2Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation 3Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation 4New studies suggest airborne SARS transmission is possible 2The death of a very special chimpanzee 2
(Date:8/28/2015)... 2015 According to a new ... Storage Systems, Thawing Equipment, Alarms), by Biospecimen (Human Tissue, ... End User - Global Forecast to 2020", published by ... USD 3,731.03 Million by 2020 from USD 2,150.48 Million ... 2015 and 2020. Browse 74 Tables ...
(Date:8/28/2015)... ... ... Since the initial launch of FireflySci Inc. (FFS) in early 2015, the company continues to ... such as the Fonz in a lab coat and Large Marge have been posted on ... , FireflySci is proud to be the only cuvette manufacturer is the world ...
(Date:8/27/2015)... , Aug. 27, 2015 The National ... patient,s eyes—and life—were saved by doctors at Vanderbilt University ... with NNFF, NovaBay Pharmaceuticals and Dr. John Crew ... at Seton Medical Center in Daly ... used a breakthrough approach, pioneered by Dr. Crew, that ...
(Date:8/27/2015)... ... 27, 2015 , ... Inc. Magazine released its annual list of the 5,000 ... in growth for the three years through 2014. Being named to the Inc. 5000 ... in the country. , “We are thrilled to make the Inc. 5000 list ...
Breaking Biology Technology:Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3
... Calif., May 13 /Xinhua-PRNewswire-FirstCall/ --,Kiwa Bio-Tech Products ... of an agreement establishing a joint venture ... On May 9, General Manager of ... Ruijun Li and his associates visited Kiwa,s,headquarters ...
... DANBURY, Conn., May 13 Biodel Inc. (Nasdaq:,BIOD) today ... in,the NASDAQ Biotechnology Index (NBI), effective as of the ... pleased to be included in the NASDAQ Biotechnology Index ... consistent,achievement of its goals," stated Dr. Solomon Steiner, Chairman ...
... Leading Companies that Promote a ... Healthy Workplace, ... a national non-profit organization of large,employers, today named GlaxoSmithKline (GSK) a ... employees and their,families., GSK was among 52 employers to receive ...
Cached Biology Technology:Kiwa Bio-Tech Confirms Joint Venture Agreement With Shijiazhuang Huaxing Animal Medicine Co., Ltd. 2Kiwa Bio-Tech Confirms Joint Venture Agreement With Shijiazhuang Huaxing Animal Medicine Co., Ltd. 3Biodel Inc. Added to NASDAQ Biotechnology Index 2GlaxoSmithKline Named A Top Employer for Promoting Healthy Lifestyles 2GlaxoSmithKline Named A Top Employer for Promoting Healthy Lifestyles 3GlaxoSmithKline Named A Top Employer for Promoting Healthy Lifestyles 4
Supplemental reagent for annexin V assay....
Conjugate Quality Control Evaluation Specificity: Conjugate Quality Control Evaluation ...
Ultra-sensitive, non-radioactive detection of rat Big Endothelin-1 (Big ET-1)...
... Design , Customer Peptide Synthesis , 20 Amino Acid ... , 20 mg will return to customer for future usage ... 2 , Maintenance 102 days/each , ... x5 /each , Test bleed (app. 5 ...
Biology Products: