Navigation Links
Master regulator found for regenerating nerve fibers in live animals
Date:10/25/2009

Boston, Mass. -- Researchers at Children's Hospital Boston report that an enzyme known as Mst3b, previously identified in their lab, is essential for regenerating damaged axons (nerve fibers) in a live animal model, in both the peripheral and central nervous systems. Their findings, published online by Nature Neuroscience on October 25, suggest Mst3b or agents that stimulate it as a possible means of treating stroke, spinal cord damage and traumatic brain injury. Normally, neurons in the central nervous system (the brain and spinal cord) cannot regenerate injured nerve fibers, limiting people's ability to recover from brain or spinal cord injuries.

The study, led by Nina Irwin, PhD and Larry Benowitz, PhD, of the Laboratories for Neuroscience Research in Neurosurgery and the F.M. Kirby Neurobiology Center at Children's, builds on previous discoveries in the lab. In 2002, they showed that a naturally occurring small molecule, inosine, stimulates axon regeneration, later showing that it helps restore neurological functions in animal models of injury. In 2006, Benowitz and colleagues reported a previously unknown growth factor, oncomodulin, to have dramatic effects on axon growth.

Investigating the mechanisms of action of inosine and oncomodulin, Irwin and Benowitz discovered that both compounds activate Mst3b, an enzyme that appears to be a master regulator of a cell-signaling pathway controlling axon growth. Mst3b, a protein kinase, in turn activates signals that switch on the genes necessary for axons to grow.

Working with live rats whose optic nerve was damaged (a common model of central-nervous-system injury), Irwin, Benowitz and colleagues show that in the absence of Mst3b, axons show very little regeneration, even in the presence of factors known to enhance axon growth. In cell cultures, axon growth increased when activated Mst3b was expressed in the neurons.

"All the growth factors we've tested oncomodulin,
'/>"/>

Contact: James Newton
james.newton@childrens.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2

Related biology news :

1. New research network at McMaster aims to build a better eye
2. Master gene that switches on disease-fighting cells identified by scientists
3. Suppressing cancer with a master control gene
4. McMaster researchers discover new mode of how diseases evolve
5. Master gene plays key role in blood sugar levels
6. New book helps medical students master clinical skills
7. New master switch found in the brain that regulates appetite and reproduction
8. McMaster University engineering professor receives Humboldt Research Award
9. Master Lock(R) smartTOUCH(TM) Garage Door Opener to be Featured on Hispanic Network Radio Weekend Show
10. Bits of junk RNA aid master tumor-suppressor gene
11. Regulatory role of key molecule discovered at Hebrew U.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... French . NAIROBI (22 ... soils looming as a major threat to food security across ... the last five years, 1.7 million African farmers in 13 ... hectares and helped them double or even triple crop yields. ... in Africa (AGRA) focuses on intensive efforts initiated five years ...
(Date:8/22/2014)... in basic and clinical research and technological advances, ... complex offensive spanning multiple fronts. , Work happening ... help find new and more selective therapies for ... a specific enzyme overexpressed in certain cancersand they ... tumours. , Chemistry professor Christopher Cairo and his ...
(Date:8/22/2014)... is a multifunctional enzyme that localizes ... neuroprotective and cholesterol-synthesizing activities. DHCR24 overexpression ... amyloid β deposition. Dr. Xiuli Lu ... China constructed two recombinant adenoviruses (Ad-rSYN1-DHCR24-myc ... specifically in neuronal cells. They also ...
Breaking Biology News(10 mins):Effort to confront Africa's soil health crisis helps millions of farmers triple yields 2Effort to confront Africa's soil health crisis helps millions of farmers triple yields 3Effort to confront Africa's soil health crisis helps millions of farmers triple yields 4New enzyme targets for selective cancer therapies 2New enzyme targets for selective cancer therapies 3
... paleoclimate history by NASA,s Goddard Institute for Space Studies ... climate changes this century, including multiple meters of sea ... By looking at how the Earth,s climate responded to ... question raised by ongoing human-caused climate change: "What is ...
... Mellon University,s Roberto R. Gil and Rongchao Jin ... of infinitesimal gold nanoparticles, which could advance the ... drug development. Their approach offers a ... nanoparticles because it can determine whether the nanoparticles ...
... New York, NYDecember 7, 2011Thanks to a new ... be able to diagnose in their offices non-periodic ... Non-periodic arrhythmias include atrial and ventricular fibrillation, which ... can in some cases be life-threatening. ...
Cached Biology News:Paleoclimate record points toward potential rapid climate changes 2Paleoclimate record points toward potential rapid climate changes 3Paleoclimate record points toward potential rapid climate changes 4Carnegie Mellon researchers use NMR to determine whether gold nanoparticles exhibit 'handedness' 2Carnegie Mellon researchers use NMR to determine whether gold nanoparticles exhibit 'handedness' 3New Columbia engineering technique diagnoses non-periodic arrhythmias in a single heartbeat 2
(Date:8/21/2014)... including DESY scientists has observed tiny quantum vortices in ... the journal Science that the exotic vortices ... It is the first time that the quantum vortices, ... what is known as superfluid helium, have been detected ... says Andrey Vilesov of the University of Southern California, ...
(Date:8/21/2014)... August 21, 2014 ... has announced the addition of the  "Global ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... therapy, is a means of replacing hormones ... the body. This type of therapy is ...
(Date:8/21/2014)... 21, 2014 Telomere Biosciences, LLC (Telomere ... "TELO-20 for Dogs" with Telomerase Activation Complex ... the world for dogs. Telomeres are the protective ... the body. A wealth of ground-breaking research by ... Science and Aging, including Nobel laureates, has demonstrated ...
(Date:8/21/2014)... Mass. , Aug. 21, 2014  Decision ... Brazil and ... The uptake of several newly approved agents, the ... this indication and the launch of emerging biologics ... markets. In particular, the emerging IL-5 inhibitors will ...
Breaking Biology Technology:Scientists observe quantum vortices in cold helium droplets 2Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3
... Technologies, Inc., a leading,provider of innovative services ... today that Shabbir Anik, Ph.D.,will join the ... Officer. Dr.,Anik, the former President of Pharmaceutical ... Althea,s expansion of its product development,clinical trial ...
... advanced and powerful electron microscope on the planetcapable of ... for Electron Microscopy at McMaster University. , "We are ... of such a high calibre," says Gianluigi Botton, director ... Materials Science and Engineering, and the project,s leader. ...
... N.C., Oct. 20 With limited information ... support of Continuing,Medical Education activities, pharmaceutical, biotechnology ... understand the value of CME,support and strategies ... practitioner behaviors and patient outcomes. In the ...
Cached Biology Technology:Althea Technologies Appoints Dr. Shabbir Anik as Chief Executive Officer 2McMaster University unveils world's most advanced microscope 2Bio-Pharma Industry Improves Patient Outcomes Through Continuing Medical Education (CME) 2
... first instrument engineered to match the speed ... thousands of research centers worldwide. It uses ... are ideally suited for high-speed temperature cycling ... high surface-area-to-volume ratio. ,By combining glass capillary ...
... Antibody is a mouse monoclonal antibody ... 26 kDa glutathione-S-transferase (GST) domain from ... is suitable for detecting fusion proteins ... E. coli , yeast, mammalian, and ...
... at 470 nm; includes interface cable to S2000; ... into rack or desktop boxes The ... LED that produces either pulsed or continuous output ... for fluorescence measurements. The source is designed for ...
Sterile, Cell culture tested...
Biology Products: