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Master gene plays key role in blood sugar levels
Date:11/27/2008

of this storage form of sugar can cause the liver to fail.

"It's one of the few examples of a metabolic genetic disease that can be created by a deficiency in a coactivator," O'Malley said.

He actually identified the first coactivator SRC-1. His work with another called SRC-3 has led to better understanding of cancer and inflammation and led to the understanding of drugs such as tamoxifen in the treatment of breast cancer.

"This again shows that these coactivators are important master genes for physiology," said O'Malley. "In the case of SRC-3, if there is too much, you get cancer. Here, if you get too little SRC-2, you can't maintain your blood sugar levels."

He believes that potentially too much SRC-2 could raise the levels of glucose in the blood. That would call for increased production of insulin. Often, the pancreas fails after being forced to produce continuous, high levels of insulin. This can result in adult-onset diabetes.

O'Malley and his colleagues plan to start studying the activity in humans in the near future. Eventually, he hopes they can find ways to target the activity of SRC-2 with a drug.


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Contact: Kimberlee Norton
kknorton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

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