Navigation Links
Master gene SRC-3 enables breast cancer growth, invasion
Date:2/12/2010

HOUSTON - (Feb. 12, 2009) The master gene called SRC-3 (steroid receptor coactivator 3) not only enhances estrogen-dependent growth of cancer cells by activating and encouraging the transcription of a genetic message into a protein, it also sends a signal to the cell membrane to promote cell motility or movement a key element of cancer spread or metastasis, said Baylor College of Medicine (www.bcm.edu) researchers and collaborators in a report that appears in the current issue of the journal Molecular Cell.

The finding not only uncovers a new activity for SRC-3 at the cell's periphery, it also clears up a mystery about how the message that tells a cell to invade gets from the epidermal growth factor receptor (EGFR) to the activating enzyme called FAK (focal adhesion kinase) found on the cell's membrane, said Dr. Bert O'Malley (http://www.bcm.edu/mcb/?PMID=7694), chair of molecular and cellular biology (http://www.bcm.edu/mcb/?PMID=0) at BCM and the report's senior author.

"Two-thirds of breast cancers over express the gene SRC-3," said O'Malley, who is the 2008 National Medal of Science recipient. "The work represented in this paper shows that a coactivator gene (SRC-3) can produce an alternative form of its coactivator protein a shorter form that is missing the part of the protein that keeps it in the nucleus. With that portion (called an exon) gone, it leaves the nucleus and goes into the cytoplasm (or general area of the cell) and travels to the membrane," he said.

"At the membrane, the enzyme PAK1 (p21-activted kinase 1) phosphorylates (attaches a phosphate molecule that activates the coactivator) SRC-3, allowing it to function at the membrane," said O'Malley, responsible for identifying the first receptor coactivator and advancing the field in general.

The finding explains how the epidermal growth factor receptor at the membrane gets a signal to the enzyme that tells the cell to move and ultimately grow, allowing the cancer to invade surrounding tissue, said O'Malley.

"Now we have a final picture as to why epidermal growth factor receptor and the estrogen receptor are the most dangerous combination of molecules overproduced in breast cancer," said O'Malley. "When they are both over functioning, people die quickly and are resistant to therapy."


'/>"/>

Contact: Dipali Pathak
pathak@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Related biology news :

1. Master regulator found for regenerating nerve fibers in live animals
2. New research network at McMaster aims to build a better eye
3. Master gene that switches on disease-fighting cells identified by scientists
4. Suppressing cancer with a master control gene
5. McMaster researchers discover new mode of how diseases evolve
6. Master gene plays key role in blood sugar levels
7. New book helps medical students master clinical skills
8. New master switch found in the brain that regulates appetite and reproduction
9. McMaster University engineering professor receives Humboldt Research Award
10. Master Lock(R) smartTOUCH(TM) Garage Door Opener to be Featured on Hispanic Network Radio Weekend Show
11. Bits of junk RNA aid master tumor-suppressor gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... the health IT company that operates the largest health ... today announced a Series B investment from BlueCross BlueShield ... investment and acquisition accelerates higi,s strategy to create the ... activities through the collection and workflow integration of ambient ... secures data today on behalf of over 36 million ...
(Date:3/24/2017)... 2017 The Controller General of Immigration from Maldives ... Algeen have received the prestigious international IAIR Award for the most ... Reading ... Maldives ... Abdulla Algeen (small picture on the right) have received the IAIR award ...
(Date:3/23/2017)... DUBLIN , Mar. 23, 2017 Research ... Anti-Theft System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 8.8% over the next ... This industry report analyzes the market estimates and forecasts for all ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... Oct. 9, 2017  BioTech Holdings announced today ... which its ProCell stem cell therapy prevents limb ... The Company, demonstrated that treatment with ProCell resulted ... saved as compared to standard bone marrow stem ... resulted in reduction of therapeutic effect.  ...
(Date:10/9/2017)... , ... October 09, 2017 , ... ... four-tiered line of medical marijuana products targeting the needs of consumers who are ... of Kindred takes place in Phoenix, Arizona. , As operators of two successful ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially ... cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using their own facilities, ...
(Date:10/6/2017)... ... 06, 2017 , ... On Tuesday, October 24th, ABC² (Accelerate ... first-ever adaptive clinical trial for glioblastoma (GBM). The featured speaker will be Dr. ... open to the public, but registration is required. , WHAT: ABC² Brain ...
Breaking Biology Technology: