Navigation Links
Master gene SRC-3 enables breast cancer growth, invasion
Date:2/12/2010

HOUSTON - (Feb. 12, 2009) The master gene called SRC-3 (steroid receptor coactivator 3) not only enhances estrogen-dependent growth of cancer cells by activating and encouraging the transcription of a genetic message into a protein, it also sends a signal to the cell membrane to promote cell motility or movement a key element of cancer spread or metastasis, said Baylor College of Medicine (www.bcm.edu) researchers and collaborators in a report that appears in the current issue of the journal Molecular Cell.

The finding not only uncovers a new activity for SRC-3 at the cell's periphery, it also clears up a mystery about how the message that tells a cell to invade gets from the epidermal growth factor receptor (EGFR) to the activating enzyme called FAK (focal adhesion kinase) found on the cell's membrane, said Dr. Bert O'Malley (http://www.bcm.edu/mcb/?PMID=7694), chair of molecular and cellular biology (http://www.bcm.edu/mcb/?PMID=0) at BCM and the report's senior author.

"Two-thirds of breast cancers over express the gene SRC-3," said O'Malley, who is the 2008 National Medal of Science recipient. "The work represented in this paper shows that a coactivator gene (SRC-3) can produce an alternative form of its coactivator protein a shorter form that is missing the part of the protein that keeps it in the nucleus. With that portion (called an exon) gone, it leaves the nucleus and goes into the cytoplasm (or general area of the cell) and travels to the membrane," he said.

"At the membrane, the enzyme PAK1 (p21-activted kinase 1) phosphorylates (attaches a phosphate molecule that activates the coactivator) SRC-3, allowing it to function at the membrane," said O'Malley, responsible for identifying the first receptor coactivator and advancing the field in general.

The finding explains how the epidermal growth factor receptor at the membrane gets a signal to the enzyme that tells the cell to move and ultimately grow, allowing the cancer to invade surrounding tissue, said O'Malley.

"Now we have a final picture as to why epidermal growth factor receptor and the estrogen receptor are the most dangerous combination of molecules overproduced in breast cancer," said O'Malley. "When they are both over functioning, people die quickly and are resistant to therapy."


'/>"/>

Contact: Dipali Pathak
pathak@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Related biology news :

1. Master regulator found for regenerating nerve fibers in live animals
2. New research network at McMaster aims to build a better eye
3. Master gene that switches on disease-fighting cells identified by scientists
4. Suppressing cancer with a master control gene
5. McMaster researchers discover new mode of how diseases evolve
6. Master gene plays key role in blood sugar levels
7. New book helps medical students master clinical skills
8. New master switch found in the brain that regulates appetite and reproduction
9. McMaster University engineering professor receives Humboldt Research Award
10. Master Lock(R) smartTOUCH(TM) Garage Door Opener to be Featured on Hispanic Network Radio Weekend Show
11. Bits of junk RNA aid master tumor-suppressor gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... NEW YORK , June 2, 2016   The ... (Weather), is announcing Watson Ads, an industry-first capability in which ... advertising, by being able to ask questions via voice or ... Marketers have long ... with the consumer, that can be personal, relevant and valuable; ...
(Date:5/20/2016)... May 20, 2016  VoiceIt is excited to ... VoicePass. By working together, VoiceIt and ... VoiceIt and VoicePass take slightly different approaches to ... both security and usability. ... this new partnership. "This marketing and ...
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Alex,s Lemonade Stand Foundation (ALSF), a ... will open a state-of-the-art bioinformatics lab, using ,big data, ... announcement comes as Liz Scott , co-executive director ... Moonshot Summit in Washington, D.C. , ... participant and advocate of pediatric cancer research and awareness. ...
(Date:6/27/2016)... June 27, 2016  Global demand for enzymes ... through 2020 to $7.2 billion.  This market includes ... cleaning products, biofuel production, animal feed, and other ... and biocatalysts). Food and beverages will remain the ... increasing consumption of products containing enzymes in developing ...
(Date:6/27/2016)... GUELPH, ON , June 27, 2016 /PRNewswire/ - BIOREM ... it has been advised by its major shareholders, Clean ... LP, United States based venture ... common shares of Biorem (on a fully diluted, as ... for the disposition of their entire equity holdings in ...
(Date:6/27/2016)...  Sequenom, Inc. (NASDAQ: SQNM ), a ... the development of innovative products and services, announced today ... States denied its petition to review decisions ... U.S. Patent No. 6,258,540 (",540 Patent") are not patent ... Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories decision.  ...
Breaking Biology Technology: