Navigation Links
Marine biomedicine researchers decode structure of promising sea compound
Date:8/28/2009

Scientists at Scripps Institution of Oceanography at UC San Diego and their colleagues at Creighton University have deciphered the highly unusual molecular structure of a naturally produced, ocean-based compound that is giving new understanding of the function of mammalian nerve cells.

The findings are reported in the Aug. 27 online version of the journal Chemistry & Biology by principal co-investigators William Gerwick, professor of oceanography and pharmaceutical sciences at the Center for Marine Biotechnology and Biomedicine (CMBB) at Scripps Institution of Oceanography and UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences and Thomas Murray, professor and chair of pharmacology at the Creighton University School of Medicine in Omaha, Neb.

Scripps scientists collected cyanobacteria, tiny photosynthetic sea organisms, in Hoia Bay off Papua New Guinea in 2002 and recently discovered that the bacteria produce a compound with a structure previously unseen in biomedicine.

The compound, which the researchers have dubbed hoiamide A, offers a novel template for drug development.

"We have seen some of hoiamide A's features in other molecules, but separately," said Alban Pereira, a postdoctoral researcher in Scripps' CMBB and a paper coauthor. "We believe this new template may be important because it's showing different mechanisms of actiondifferent ways to interact with neurons, possibly with a good therapeutic effect for such diseases as epilepsy, hypoxia-ischemia and several neurodegenerative disorders."

In pharmacological tests conducted at Creighton University, Hoiamide A was shown to interact with the same important therapeutic target as analgesic, antiarrhythmic, antiepileptic and neuroprotective drugs.

Dan Edwards and Luke Simmons, former members of Gerwick's laboratory, collected a mixture of cyanobacteria species Lyngbya majuscula and Phormidium gracile in May 2002 at five- to 10-meters (16 to 33 feet) depth from Hoia Bay. Extractions of this sample were shown to have intriguing neurochemical properties in assays run at Creighton University's School of Medicine. Gerwick and Murray's laboratories then collaborated to isolate the neuroactive substance and characterize its extraordinarily complex chemical structure.

"Classically, what we know about the workings of the human nervous system has come largely from studies of different toxins on the function of model systems, such as in this case, the action of hoiamide A on nerve cells in petri dish cultures," said Gerwick. "The toxins serve as 'molecular tools' for manipulating cells at an extremely microscopic scale. Ultimately, by understanding how neurons work at this detailed level, and having a set of tools such as hoiamide A, we can envision the development of new, more effective treatments for such diverse conditions as epilepsy, pain control and memory and cognition enhancement. The natural world still has many valuable molecules left for us to discover and hopefully develop into new classes of medicines."


'/>"/>

Contact: Mario Aguilera or Annie Reisewitz
scrippsnews@ucsd.edu
858-534-3624
University of California - San Diego
Source:Eurekalert  

Related biology news :

1. Marines land at UO, leave with plans to wear Oregon-made training suits
2. Gulf of Mexico dead zone to be studied by University of Texas at Austin marine scientists
3. US Army, US Navy, US Air Force, US Marines, US Department of Defense conference held at UH
4. Scripps scientists discover fluorescence in key marine creature
5. Pollution from marine vessels linked to heart and lung disease
6. Marine scientists warn human safety, prosperity depend on better ocean observing system
7. Present-day species of piranha result from a marine incursion into the Amazon Basin
8. Global climate change: The impact of El Niño on Galápagos marine iguanas
9. Global climate change: The impact of El Nio on Galpagos marine iguanas
10. Why diving marine mammals resist brain damage from low oxygen
11. Resilience concepts poised to aid management of coastal marine ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Marine biomedicine researchers decode structure of promising sea compound
(Date:3/18/2016)... LONDON , March 18, 2016 ... Established Suppliers of Biometrics, ICT, Manned & Unmanned Vehicles, Physical ... & security companies in the border security market and ... and Europe has led ... your companies improved success. --> defence & ...
(Date:3/14/2016)... Allemagne, March 14, 2016 ... - --> - Renvoi : image disponible ... --> --> DERMALOG, ... fournit de nouveaux lecteurs d,empreintes digitales pour l,enregistrement ... DERMALOG sera utilisé pour produire des cartes d,identité ...
(Date:3/9/2016)... , March 9, 2016 This BCC ... future states of the RNA Sequencing (RNA Seq) market ... such as instruments, tools and reagents, data analysis, and ... various segments of the RNA-Sequencing market such as RNA-Sequencing ... Identify the main factors affecting each segment and forecast ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... MedDay, a biotechnology company focused on the treatment ... Moukheibir as Chairman of its Board of Directors. ... , who contributed to the rapid development of the Company ... started her career in strategy consulting and investment banking in ... .  She held C-Suite level roles in some of ...
(Date:4/26/2016)... ... April 26, 2016 , ... ... that Ardy Arianpour has joined the company as Chief Business Officer. Arianpour, a ... innovative genomic technologies to market, was most recently Chief Commercial Officer of Pathway ...
(Date:4/26/2016)... ... 2016 , ... Mr. Palmer created the RPO business for Ceridian and lead ... managed services contract in the U.S. intelligence community with The SI (a Lockheed Martin ... Younger, founder of Accolo. “We are growing and his experience guiding our expansion ...
(Date:4/26/2016)... Washington (PRWEB) , ... April 26, 2016 , ... ... today announced receipt of a significant operating grant from 1Plus12 Corporation. The grant ... to commence pre-proposal activities as outlined on the organization's website http://www.ivsci.org ...
Breaking Biology Technology: