Navigation Links
Mapping the genetic locus for triglycerides
Date:4/25/2008

Researchers have mapped out a region on human chromosome 1 that contributes to genetically elevated blood triglyceride levels, a major risk factor for heart disease.

Triglycerides (TG), the main form of dietary fat, continuously circulate in the blood, but if their concentration elevates the risk of atherosclerosis and subsequently heart disease increases. Circulating TG levels depend on many factors including diet, exercise, and smoking, but around 40% of the variation in the population is due to genetics.

To locate the genes contributing to increased TG levels, Qing Wang and colleagues scanned 714 Caucasians from 388 families with premature heart disease. They identified a novel region on chromosome 1, 1p31-32.

While this genetic locus does contain 375 known genes, the researchers highlighted three genes that are especially promising candidates: angiopoietin-like 3, which inhibits enzymes that break down fats; the receptor for the appetite hormone leptin; and sterol carrier protein 2, which helps convert cholesterol into bile acids.

The researchers also note that another recent study identified a single nucleotide polymorphism associated with elevated TG levels in the exact same region, solidifying this part of chromosome 1 as the TG region.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Prediction of RNA pseudoknots using heuristic modeling with mapping and sequential folding
2. Genetic sequencing of protein from T. rex bone confirms dinosaurs link to birds
3. American College of Medical Genetics makes genetic testing recommendations in new policy statement
4. Scientists clarify a mechanism of epigenetic inheritance
5. Genetic variant mimics effect of heart failure medications
6. Researchers discover critical detail of cellular defense against genetic mistakes
7. Concentrating on different aspects of pain leads to breakthrough in migraine genetics
8. Genetic Engineering & Biotechnology News reports on growing use of cell-based assays
9. Largest ever study of genetics of common disease just got bigger
10. A genetic cause for iron deficiency
11. Geneticist Francis Collins named first recipient of Inamori Ethics Prize at Case Western Reserve
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
Breaking Biology News(10 mins):
(Date:8/11/2017)... , ... August 11, 2017 , ... Algenist continues to ... formulation unlocking collagen like never before. , Collagen is the key structural element ... market with Liquid Collagen™, which include: , First to ...
(Date:8/10/2017)... ... August 09, 2017 , ... Teachers from three Philadelphia ... August 14th through the 16th, the University City Science Center will kick off ... 2016, provides Philadelphia-based middle school educators an opportunity for professional development related to ...
(Date:8/10/2017)... Bahama (PRWEB) , ... August 09, 2017 , ... Okyanos ... will take place at the Pelican Bay Hotel in Freeport, Grand Bahama on September ... pre-registration is required. , With oversight from the Ministry of Health’s National Stem ...
(Date:8/10/2017)... ... August 10, 2017 , ... ... establishing Kinokuniya Company Ltd. as its exclusive sales representative for SPIE Journals in ... for the SPIE Digital Library in Japan. , “We look forward to expanding ...
Breaking Biology Technology: