Navigation Links
Mapping the embryonic epigenome
Date:5/9/2013

7me3, involves the highly specific addition of three methyl groups to a type of histone named H3. "People have generally not thought of these two 'epigenetic' modifications as being very different in terms of their function," says Ren.

The current study puts an end to that notion. The researchers found in their analysis of those modifications across the genomereferred to, collectively, as the epigenomethat master genes that govern the regulation of early embryonic development tend largely to be switched off by H3K27me3 histone methylation. Meanwhile, those that orchestrate the later stages of cellular differentiation, when cells become increasingly committed to specific functions, are primarily silenced by DNA methylation.

"You can sort of glean the logic of animal development in this difference," says Ren. "Histone methylation is relatively easy to reverse. But reversing DNA methylation is a complex process, one that requires more resources and is much more likely to result in potentially deleterious mutations. So it makes sense that histone methylation is largely used to silence master genes that may be needed at multiple points during development, while DNA methylation is mostly used to switch off genes at later stages, when cells have already been tailored to specific functions, and those genes are less likely to be needed again."

The researchers also found that the human genome is peppered with more than 1,200 large regions that are consistently devoid of DNA methylation throughout development. It turns out that many of the genes considered master regulators of development are located in these regions, which the researchers call DNA methylation valleys (DMVs). Further, the team found that the DMVs are abnormally methylated in colon cancer cells. While it has long been known that aberrant DNA methylation plays an important role in various cancers, these results suggest that changes to the cell's DNA methylation machinery itself may b
'/>"/>

Contact: Rachel Steinhardt
Rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Mapping of cancer cell fuel pumps paves the way for new drugs
2. Brain Activity Mapping Project aims to understand the brain
3. Mapping effort charts restoration tack for Great Lakes
4. Carnegie debuts revolutionary biosphere mapping capability at AGU
5. USDA scientists collaborate with global researchers to advance the mapping of the barley genome
6. Influenza research: Can dynamic mapping reveal clues about seasonality?
7. Physics and math shed new light on biology by mapping the landscape of evolution
8. Geosphere: How geology, technology, modeling, and mapping see into Earths past and present
9. Road-mapping the Asian brain
10. Beyond base pairs: Mapping the functional genome
11. Speeding up drug discovery with rapid 3-D mapping of proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Helping people recover from the debilitating effects of ... requires deep knowledge of neurophysiology as well as ... options and outcomes has been the primary focus ... biomedical engineering, since he joined the NJIT faculty ... whose significance is underscored by substantial funding from ...
(Date:7/29/2014)... Dentistry (UM SOD) and Medicine (UM SOM) jointly ... $10.7 million grant award from the National Institute ... National Institutes of Health to study the causes, ... grant, which renews a previous $12 million five-year ... the research by studying chlamydial and gonorrheal diseases ...
(Date:7/29/2014)... brings together two of the major disciplines behind Jurassic ... fossils through stunning photographs and unique illustrations. , Fossil ... details the incredible preservation and diversity of fossilised insects ... these remarkable fossils can tell us about the ancient ... planet. Like the mosquito in Jurassic Park, many of ...
Breaking Biology News(10 mins):Continuing the quest for better stroke therapies 2Continuing the quest for better stroke therapies 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 4Unique images bring fossil insects back to life 2
... ecosystem below an Antarctic glacier and learned that it survived ... growth. Described in the April 17 issue of ... a pool of brine trapped below Taylor Glacier and next ... Priscu , co-author of the Science article. Priscu ...
... over, Y chromosome it,s time X got some ... chromosome associated with being female, University of California, Berkeley, ... history of the X chromosome is every bit as ... important clues to the origins and benefits of sexual ...
... Sven Enerbck, Professor at the Institute of Biomedicine at the ... scientists who published their results in The New England ... Enerbck and others show that adults use brown fat to ... new possibilities in treating overweight and obesity. It has ...
Cached Biology News:Ancient ecosystem thrives millions of years below Antarctic glacier 2The story of X -- evolution of a sex chromosome 2The story of X -- evolution of a sex chromosome 3The story of X -- evolution of a sex chromosome 4
(Date:7/30/2014)... (PRWEB) July 30, 2014 LayerBio, Inc., ... completion of its first round of seed financing from ... enable preliminary efforts to develop a novel sustained-release product ... of our investors and their commitment to this important ... LayerBio. "Ophthalmology is one of many areas in which ...
(Date:7/29/2014)... technologists have hurdled a number of significant technological ... revolutionary observing technology originally created for the James ... Principal Investigator Harvey Moseley, a scientist at NASA,s ... demonstrated that electrostatically actuated microshutter arrays that ... are as functional as the current technology,s ...
(Date:7/29/2014)... JOLLA, Calif. , July 29, 2014 ... diagnostic and therapeutic company focused on extending the healthy, ... hired Franz Och , Ph.D., an expert in ... Data Scientist. Och comes to HLI from Google where ... Google Translate. He will report directly to HLI Co-Founder ...
(Date:7/29/2014)... researchers has created a new way of manufacturing ... surfaces, made by self-assembly of carbon nanotubes, could ... controllable mechanical stiffness and strength, or the ability ... "We have demonstrated that mechanical forces can be ... microstructures, and that we can independently control ...
Breaking Biology Technology:Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 2Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 3A new way to make microstructured surfaces 2
... Call Today at 4:30 p.m. Eastern Time - SAN FRANCISCO, March ... today reported on its corporate progress and financial results ... a very productive 2008 and are looking forward to an equally ... are on track to be in Phase 3 testing in all ...
... announces that its lead compound for inhibition of tau ... has been recognized as the most potent inhibitor of ... to date. Mutations of this gene are believed ... frequent cause of Parkinson,s Disease.TauTaTis, lead compound is a ...
... Traceability Down to the Unit Level to Secure Products and ... ... Southborough, MA (PRWEB) March 16, 2009 -- PHARMORX Security™, a ... provider, today announced the availability of its new comprehensive technology ...
Cached Biology Technology:Medivation Reports Fourth Quarter and Year-End 2008 Financial Results and Provides Corporate Update 2Medivation Reports Fourth Quarter and Year-End 2008 Financial Results and Provides Corporate Update 3Medivation Reports Fourth Quarter and Year-End 2008 Financial Results and Provides Corporate Update 4Medivation Reports Fourth Quarter and Year-End 2008 Financial Results and Provides Corporate Update 5Medivation Reports Fourth Quarter and Year-End 2008 Financial Results and Provides Corporate Update 6Medivation Reports Fourth Quarter and Year-End 2008 Financial Results and Provides Corporate Update 7Medivation Reports Fourth Quarter and Year-End 2008 Financial Results and Provides Corporate Update 8TauTaTis Discovers Potent Inhibitor of Parkinson's Disease Gene Activity 2PHARMORX Security Introduces New Technology Solutions for Counterfeiting, Grey Market Diversion, Track & Trace 2PHARMORX Security Introduces New Technology Solutions for Counterfeiting, Grey Market Diversion, Track & Trace 3
RABBIT ANTI RAT AQUAPORIN 5...
... 2.0 mL samples for freezing point determinations. Includes built-in printer, keypad, and ... optional scanner. RS-232 port. Microprocessor-controlled autocalibration. Two-step Calibration. ... ... ...
MAb to Hu-IFN-Gamma RC2 (CD118), NON-Neutralizing, Clone MMHGR-2 Binds to but does not neutralize human interferon gamma receptor...
Recombinant Rat CINC-2 alpha, CF...
Biology Products: