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Mapping the brain: New technique poised to untangle the complexity of the brain
Date:4/10/2011

Scientists have moved a step closer to being able to develop a computer model of the brain after developing a technique to map both the connections and functions of nerve cells in the brain together for the first time.

A new area of research is emerging in the neuroscience known as 'connectomics'. With parallels to genomics, which maps the our genetic make-up, connectomics aims to map the brain's connections (known as 'synapses'). By mapping these connections and hence how information flows through the circuits of the brain scientists hope to understand how perceptions, sensations and thoughts are generated in the brain and how these functions go wrong in diseases such as Alzheimer's disease, schizophrenia and stroke.

Mapping the brain's connections is no trivial task, however: there are estimated to be one hundred billion nerve cells ('neurons') in the brain, each connected to thousands of other nerve cells making an estimated 150 trillion synapses. Dr Tom Mrsic-Flogel, a Wellcome Trust Research Career Development Fellow at UCL (University College London), has been leading a team of researchers trying to make sense of this complexity.

"How do we figure out how the brain's neural circuitry works?" he asks. "We first need to understand the function of each neuron and find out to which other brain cells it connects. If we can find a way of mapping the connections between nerve cells of certain functions, we will then be in a position to begin developing a computer model to explain how the complex dynamics of neural networks generate thoughts, sensations and movements."

Nerve cells in different areas of the brain perform different functions. Dr Mrsic-Flogel and colleagues focus on the visual cortex, which processes information from the eye. For example, some neurons in this part of the brain specialise in detecting the edges in images; some will activate upon detection of a horizontal edge, others by a vertical edge. Higher u
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Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

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