Navigation Links
Map of herpes virus protein suggests a new drug therapy
Date:7/6/2010

BOSTON (July 6, 2010) The mechanism by which a herpes virus invades cells has remained a mystery to scientists seeking to thwart this family of viruses. New research funded by the National Institutes of Health and published online in advance of print in Nature Structural & Molecular Biology reveals the unusual structure of the protein complex that allows a herpes virus to invade cells. This detailed map of a key piece of the herpes virus "cell-entry machinery" gives scientists a new target for antiviral drugs.

"Most viruses need cell-entry proteins called fusogens in order to invade cells. We have known that the herpes virus fusogen does not act alone and that a complex of two other viral cell-entry proteins is always required. We expected that this complex was also a fusogen, but after determining the structure of this key protein complex, we found that it does not resemble other known fusogens," said senior author Ekaterina Heldwein, PhD, assistant professor in the molecular biology and microbiology department at Tufts University School of Medicine.

"This unexpected result leads us to believe that this protein complex is not a fusogen itself but that it regulates the fusogen. We also found that certain antibodies interfere with the ability of this protein complex to bind to the fusogen, evidence that antiviral drugs that target this interaction could prevent viral infection," Heldwein continued. Heldwein is also a member of the biochemistry and molecular microbiology program faculties at the Sackler School of Graduate Biomedical Sciences at Tufts.

"Katya Heldwein's work has resulted in a map of the protein complex needed to trigger herpes virus infection. The NIH Director's New Innovator Awards are designed to support such breakthroughs. This research not only adds to what we know about how herpes viruses infect mammalian cells, but also sets the stage for new therapeutics that restrict herpes virus's access to the ce
'/>"/>

Contact: Siobhan Gallagher
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Sleeping Beauty hooks up with herpes to fight brain disease
2. Herpes virus: To vaccinate or not to vaccinate
3. Potential new herpes therapy studied
4. Herpes drug inhibits HIV in patients infected with both viruses
5. Herpes virus link to complications in pregnancy
6. Penn researchers shine the light of venus to learn how the herpes virus invades cells
7. Wallabies and bats harbor fossil genes from the most deadly family of human viruses
8. Discovery of a hepatitis C-related virus in bats may reduce outbreaks in humans
9. Nutrients, viruses and the biological carbon pump
10. Virus explorers probe inner workings of the brain
11. 2009 H1N1 vaccine protects against 1918 influenza virus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Map of herpes virus protein suggests a new drug therapy
(Date:7/24/2014)... biodiversity, the product of 3.5 billion years of evolutionary ... of life. But it may be reaching a tipping ... and analysis of data published in Science , ... and decline of animals is contributing to what appears ... mass biological extinction event. , Since 1500, more than ...
(Date:7/24/2014)... NY)Researchers at Albert Einstein College of Medicine ... Michael J. Fox Foundation for Parkinson,s Research to translate ... disease. This drug discovery project will test chemical compounds ... developing a drug that acts on an underlying cause ... Parkinson,s help many people manage their symptoms, we are ...
(Date:7/24/2014)... Atlantic Forest is a hotspot of biodiversity and one ... tree-frogs, and toads) in the world. However, current levels ... few years has been an increase in the description ... the advance of molecular techniques and availability of samples ... number of samples for molecular and morphological analysis, researchers ...
Breaking Biology News(10 mins):Stanford biologist warns of early stages of Earth's 6th mass extinction event 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 3Albert Einstein College of Medicine receives grant from the Michael J. Fox Foundation to fund drug discovery project targeting Parkinson's 2Albert Einstein College of Medicine receives grant from the Michael J. Fox Foundation to fund drug discovery project targeting Parkinson's 3A tiny new species of frog from Brazil with a heroic name 2
... by the University of East Anglia has discovered the existence ... time this behaviour, which rarely occurs except in humans, has ... than 20 years on a population on Cousin Island in ... that no longer breed themselves often help their children to ...
... University of Alabama at Birmingham (UAB) professor of microbiology ... prize. The annual award is the highest ... include Czech nationals working in other countries. Mestecky ... and teach about the microbial environment of the gut, ...
... and the National Center for Ecological Analysis and Synthesis ... predict gene flow across landscapes. Their approach could give ... for wildlife corridors, which are crucial to protecting biodiversity. ... theory and ecological connectivity, said Brad McRae, head of ...
Cached Biology News:A helping hand from the grandparents 2A helping hand from the grandparents 3UAB microbiologist wins top Czech science honor 2Model connects circuit theory to wildlife corridors 2
(Date:7/24/2014)... leader Yung-Eun Sung has announced that they have ... graphenes which can be applied as high performance ... Sung is both a group leader at the ... Science* (IBS) and a professor at the Seoul ... with regards to the development of relative simplicity, ...
(Date:7/24/2014)... DUBLIN , July 24, 2014 ... the "Global Genomics and Proteomics Analytical Instruments Market ... http://photos.prnewswire.com/prnh/20130307/600769 Genomics is the ... is the study of the structure and functions of ... and bioinformatics tools and technology. Genomics involves the mapping ...
(Date:7/24/2014)... July 24, 2014 2014 Deep ... Industryā€¯ is a professional and in-depth research report ... Potassium Sulphate basic information, including its definition, ... overview. This research covers the international market analysis, ... industry analysis covering macroeconomic environment & economic situation ...
(Date:7/24/2014)... Francisco, CA (PRWEB) July 24, 2014 ... http://www.draperuniversity.com , is proud to announce that ... from 17 different countries will converge on the ... Valley for an intensive, experiential program focused on ... The highly selective school, currently running its sixth ...
Breaking Biology Technology:Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 2Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 3
... carbon atoms, may be the most amazing and versatile ... and flexible, graphene enables electrons to flow much faster ... electrical and optical functionalities in an exceptional way. ... revolution, with profound impact in information and communication technology ...
... FLEMINGTON, N.J., May 4, 2011 Beardsworth announces the ... Director, Clinical Operations and Project Management and the addition ... Project Manager.   (Photo:   http://photos.prnewswire.com/prnh/20110504/NY95605 ... will lead Beardsworth,s expanded focus in oncology clinical operations ...
... InterMune, Inc. (NASDAQ: ITMN ) today announced ... InterMune, will present at the Bank of America Merrill Lynch ... 11, 2011, at 1:00 p.m. PDT.   To ... other interested parties may log on to the investor relations ...
Cached Biology Technology:GRAPHENE-CA appointed an EU Future Emerging Technology flagship pilot 2Beardsworth Continues to Strengthen Oncology Operations 2
... EVO Clinical is Tecans open platform for ... quality, safety and performance in the clinical ... provided by flexible barcode reading and sample ... that the system complies with the IVD-Directive* ...
... cycler, flexible on your protocols, easy on your ... high sample throughput instrument at a highly affordable ... format: The truly user-friendly fully interchangeable block system ... of seconds without the need of any tools ...
Preparation Note: Prepared by method of Wimmer, E., et al., Biochemistry, 7, 2623 (1968). Quality Clarifier: Acceptor Activity: approx. 1000 picomoles phenylalanine per A 260 unit (not determined b...
... Tecans GenePaint system, which is based on ... steps required for performing in situ hybridization of ... key step in the study of gene expression, ... cells and tissues and can be used to ...
Biology Products: