Navigation Links
Map of herpes virus protein suggests a new drug therapy
Date:7/6/2010

BOSTON (July 6, 2010) The mechanism by which a herpes virus invades cells has remained a mystery to scientists seeking to thwart this family of viruses. New research funded by the National Institutes of Health and published online in advance of print in Nature Structural & Molecular Biology reveals the unusual structure of the protein complex that allows a herpes virus to invade cells. This detailed map of a key piece of the herpes virus "cell-entry machinery" gives scientists a new target for antiviral drugs.

"Most viruses need cell-entry proteins called fusogens in order to invade cells. We have known that the herpes virus fusogen does not act alone and that a complex of two other viral cell-entry proteins is always required. We expected that this complex was also a fusogen, but after determining the structure of this key protein complex, we found that it does not resemble other known fusogens," said senior author Ekaterina Heldwein, PhD, assistant professor in the molecular biology and microbiology department at Tufts University School of Medicine.

"This unexpected result leads us to believe that this protein complex is not a fusogen itself but that it regulates the fusogen. We also found that certain antibodies interfere with the ability of this protein complex to bind to the fusogen, evidence that antiviral drugs that target this interaction could prevent viral infection," Heldwein continued. Heldwein is also a member of the biochemistry and molecular microbiology program faculties at the Sackler School of Graduate Biomedical Sciences at Tufts.

"Katya Heldwein's work has resulted in a map of the protein complex needed to trigger herpes virus infection. The NIH Director's New Innovator Awards are designed to support such breakthroughs. This research not only adds to what we know about how herpes viruses infect mammalian cells, but also sets the stage for new therapeutics that restrict herpes virus's access to the ce
'/>"/>

Contact: Siobhan Gallagher
617-636-6586
Tufts University, Health Sciences
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Sleeping Beauty hooks up with herpes to fight brain disease
2. Herpes virus: To vaccinate or not to vaccinate
3. Potential new herpes therapy studied
4. Herpes drug inhibits HIV in patients infected with both viruses
5. Herpes virus link to complications in pregnancy
6. Penn researchers shine the light of venus to learn how the herpes virus invades cells
7. Wallabies and bats harbor fossil genes from the most deadly family of human viruses
8. Discovery of a hepatitis C-related virus in bats may reduce outbreaks in humans
9. Nutrients, viruses and the biological carbon pump
10. Virus explorers probe inner workings of the brain
11. 2009 H1N1 vaccine protects against 1918 influenza virus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Map of herpes virus protein suggests a new drug therapy
(Date:12/17/2014)... 2014 Research and Markets ( ... "Samsung Galaxy S5 - Home Button Synaptics ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... technology than the iPhone 5S, Samsung introduces for ... product. The Galaxy S5 home button ...
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ... of the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major ... demand for medical sensors in biomedical applications. Chemical ... quick and correct diagnosis during surgical procedures. The ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has ... in India 2015-2019" report to their offering. ... this market is the adoption of multimodal biometric ... characteristic of an individual for verification and identification ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... Johns Hopkins Malaria Research Institute have developed a new method ... , an important but less studied spreader of human malaria. ... primary cause of malaria in humans in South America and ... genome of the An. albimanus mosquito has not ...
... 2013 Arthur Lander, a recognized leader in the emerging ... causes for some cancers and birth defects, has been named ... UC Irvine. The Bren Professors Endowment was established with ... to help UC Irvine attract and retain the nation,s foremost ...
... has been studying several hybrid nanomaterials, i.e. combinations of synthetic ... defend his doctoral thesis at the University of Helsinki in ... on the scale of a billionth of a metre, matter ... Neither is it always known what types of effects the ...
Cached Biology News:New method for researching understudied malaria-spreading mosquitoes 2Developmental biologist Arthur Lander named Donald Bren Professor 2Is nanosilver toxic? 2Is nanosilver toxic? 3
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... AltheaDx, Inc . today announced the ... molecular pathology lab for application in biomarker discovery and ... both monitoring known and discovering new complex genetic changes ... addition of NGS greatly expands our OncoScore™ initiative and ...
... June 27, 2011 MedeAnalytics, a leading provider ... launch of its Patient Access Resource Center. Created ... end of the revenue cycle, the resource center ... and industry trends, as well as best-practice tools ...
... LA JOLLA, Calif., June 24, 2011 Cebix Incorporated ... of C-peptide, Ersatta™ (CBX129801), demonstrated a half-life ... native C-peptide. Ersatta halted the impairment in nerve conduction ... signals travel through the nerves, in an animal model ...
Cached Biology Technology:AltheaDx Incorporates Next-Generation Sequencing Into Its Clinical Testing Pipeline. 2AltheaDx Incorporates Next-Generation Sequencing Into Its Clinical Testing Pipeline. 3Cebix's Long-Acting C-Peptide Ersatta™ has Potential in Multiple Chronic Complications of Diabetes 2Cebix's Long-Acting C-Peptide Ersatta™ has Potential in Multiple Chronic Complications of Diabetes 3
... protein A media yield highly purified ... to analysis of other immunoglobulin classes, ... purification. Protein A binds to the ... from mammalian species. This ready-to-use, bottled ...
... bis- (3-D-Gluconamidopropyl)deoxycholamide White solid. HYGROSCOPIC. ... CHAPSO. Has reduced electrostatic interactions that do ... DEAE-cellulose. Aggregation number: 8-16. Purity: ≥95% ... O. Aggregation number 8 - 16, CMC ...
Goat Anti-Horse IgG(T) Antibody, Unconjugated...
Goat polyclonal to STMN2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: AKTAMAYKEK, corresponding to C terminal amino acids 2-11 of STMN2. Entrez Gene ID: 11075 Swi...
Biology Products: