Navigation Links
Many African-Americans have a gene that prolongs life after heart failure
Date:4/20/2008

About 40 percent of African-Americans have a genetic variant that can protect them after heart failure and prolong their lives, according to research conducted at Washington University School of Medicine in St. Louis and collaborating institutions.

The genetic variant has an effect that resembles that of beta blockers, drugs widely prescribed for heart failure. The new study offers a reason why beta blockers don't appear to benefit some African-Americans.

"For several years a controversy has existed in the cardiovascular field because of conflicting reports about whether beta blockers helped African-American patients," says senior author Gerald W. Dorn II, M.D., professor of medicine, associate chairman for translational research and director of the Center for Pharmacogenomics at Washington University.

"By mimicking the effect of beta blockers, the genetic variant makes it appear as if beta blockers aren't effective in these patients," he explains. "But although beta blockers have no additional benefit in heart failure patients with the variant, they are equally effective in Caucasian and African-American patients without the variant."

Co-author Stephen B. Liggett, M.D., professor of medicine and physiology at the University of Maryland School of Medicine and director of its cardiopulmonary genomics program says the discovery adds to the accumulating evidence that genetic differences contribute to the way people respond to medications and should encourage the use of genetic testing in clinical trials to identify people who can benefit from therapy tailored to their genetic makeup.

About 5 million people in the United States have heart failure, and it results in about 300,000 deaths each year. Beta blockers slow heart rate and lower blood pressure to decrease the heart's workload and prevent lethal cardiac arrhythmias.

While Caucasians with heart failure participating in clinical studies of beta blockers ha
'/>"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert

0

GOOD

Page: 1 2 3 4

Related biology news :

1. New genetic variant associated with prostate cancer in African-Americans
2. Breast cancers behave differently before and after the age of 70
3. Can micro-scaffolding help stem cells rebuild the brain after stroke?
4. Scientists ask whether microscaffolding can help stem cells rebuild brain after stroke damage
5. Fewer babies born after Caesarean delivery
6. Cigarette after Valentine snuggle deadlier for some
7. After more than 100 years apart, webworms devastate New Zealand parsnips
8. Twinkle after-effect can help retinal patients detect vision loss quickly and cheaply
9. After drought, ponds keep up with the Joneses
10. Expecting an afternoon nap can reduce blood pressure
11. Simulation reveals how body repairs balance after damage

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2009)... DigitalPersona, Inc., a leader in..., today announced that WAND Corporation, a leading...k-service restaurants, has integrated DigitalPerso...OS solutions. WAND,s quick-service customers can n...ountability and deter unauthorized manager overrid...
(Date:11/4/2009)...ire/ -- What,s the cost of saving a teenage life? ...ting from prescription medication abuse, there,s n..., may be unaware that the lock-boxes they,ve insta...ng timebomb of prescription drugs. That,s why MEDN...al supplies, has formed an exclusive partnership w...
(Date:11/4/2009)...re-FirstCall/ -- BIO-key International, Inc. (OTC ...ometric identification software is showcasing dono...conference being held at the New Orleans Conventio...vide hands-on product demonstrations of its state-.... Also, at 5 PM on Monday, October 26, Peter Lux, ...
Breaking Biology News(10 mins):WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 2WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 3MEDNET Launches MedSafe to Prevent Teenage Prescription Drug Abuse 2MEDNET Launches MedSafe to Prevent Teenage Prescription Drug Abuse 3BIO-key(R) International Exhibiting at AABB TXPO 2New 3M CDI System Promotes Lasting Clinical Documentation Improvement 48861 1New 3M CDI System Promotes Lasting Clinical Documentation Improvement 48861 2New 3M CDI System Promotes Lasting Clinical Documentation Improvement 48861 3Transdel Pharmaceuticals Provides Update on Timing of Results for Phase 3 Study 48858 1Transdel Pharmaceuticals Provides Update on Timing of Results for Phase 3 Study 48858 2Transdel Pharmaceuticals Provides Update on Timing of Results for Phase 3 Study 48858 3Cancer Related Educational Video Sharing and Interactive Community Launches Online 48855 1Cancer Related Educational Video Sharing and Interactive Community Launches Online 48855 2Cancer Related Educational Video Sharing and Interactive Community Launches Online 48855 3
...ers at the Virginia Bioinformatics Institute (VBI)...Duke University Medical Center have developed a ne...de scale in the fungal pathogen Alternaria brassic...isease, leading to considerable leaf loss in such ...nd broccoli. , Genomic methods that allow the dis...
...ons, overexcitement is deadly. To avoid this, bra...om the synapse through membrane-bound transporters...rain cells get excited to death-- a phenomenon tha... Alzheimer,s disease. , Indeed, brain deterioratio...of glutamate -- the major excitatory neurotransmit...
...y is being published in an advance online version ...ked at XPB helicase from an archaea, a single cell...es that unwind or separate the strands of the nucl...to transcription and nucleotide excision repair (N... initially identified as the gene responsible for ...
Other Biology News:New method enables gene disruption in destructive fungal pathogen 2Enzyme crystal structure reveals 'unexpected' genome repair functions 2
(Date:11/5/2009)... Wound Management Technol...ntered into a Letter of Intent to purchase all hea...ies, Inc. (OTC Bulletin Board: VHGI). The deal pro...ebt, 4,000,000 shares of WNDM and a royalty agreem...p technology being acquired from VHGI. WNDM clos...
(Date:11/5/2009)...RNewswire-FirstCall/ -- WaferGen Biosystems, Inc. ... state-of-the-art genetic analysis systems, today ... the company,s Scientific Advisory Board. His car...ing novel molecular diagnostics for cancer detecti...of computational biology systems for several biote...
(Date:11/5/2009)... Nov. 5 /PRNewswire-Asia-FirstCall/ -- BMP Sunston...the "Company") today announced,that the Company pl...s on,Monday, November 9, 2009, after the market cl...e call at 5:00 pm ET on November 9, 2009,to discus...s the call by,dialing 1-888-713-4211 or 1-617-213-...
(Date:11/5/2009)...Surgery and vision correction experts listed in th...nvolved at the recently concluded American Academy... Francisco, California. Dr. Stephen Brint, MD, Dr.... MD, Dr. Peter Rapoza, MD, Dr. Michael Raizman, MD... Dr. Edward Manche, MD, and Dr. Parag Majmudar, MD...
Breaking Biology Technology:OTCBB-WNDM Announces LOI to Acquire VHGI Assets for $10 Million Cash/Stock 2OTCBB-WNDM Announces LOI to Acquire VHGI Assets for $10 Million Cash/Stock 3WaferGen Names Christopher Sears, Ph.D., Architect of High-Value Molecular Diagnostics and Computational Biology Platforms, to Company's Scientific Advisory Board 2WaferGen Names Christopher Sears, Ph.D., Architect of High-Value Molecular Diagnostics and Computational Biology Platforms, to Company's Scientific Advisory Board 3WaferGen Names Christopher Sears, Ph.D., Architect of High-Value Molecular Diagnostics and Computational Biology Platforms, to Company's Scientific Advisory Board 4BMP Sunstone to Report Third Quarter 2009 Financial Results 2Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 2Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 3Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 4Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 5Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 6Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 7Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 8Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 9
...The Netherlands, March 10 Pepscan Therapeutics,(P...tone payment from Genmab,A/S. The milestone paymen...med at identifying human antibodies against intrac... CLIPS(TM) technology to generate immunogens that,...es against these,intractable targets. , Under ...
...March 10 Zimmer Holdings, Inc. (NYSE: ZMH ; SWX... the 29th Annual Cowen and Company Health Care Con...9, at 8:45 a.m. Eastern Time. , , A live webcast ...nvestor Relations website at http://investor.zimm...following the conference. , , About the Company ...
....J., March 10 The long-awaited speaking faculty f... & Exhibition has been posted on the conferenc...is LLC, the organizer. The chemistry faculty is c...nies and increasingly, biotech companies with smal...aker list may be viewed at www.chemoutsourcing.co...
Other Biology Technology:Pepscan Achieves First Milestone in Research Collaboration With Genmab 2Pharma ChemOutsourcing Unveils 100 Pharma & Biotech Speaker Faculty for 2009 Conference September 14-16 in Long Branch, NJ 2
... SYBR Green, TaqMan, LNA spiked TaqMan, MethyLight...specific primers are designed by avoiding cross ho... search results. Primer efficiency is enhanced by ...by connecting to the Mfold server. Beacon Designer...
Goat Anti-Human IL-17D Polyclonal Antibody, Unconjugated from R&D Systems
...-ADP, FHS-LVF and CVD-Diffuse We've combined our ...lters to create the world's first notch filter wit...andpass. Each filter features an excellent transmi...e filters -- with interference coatings applied to...
Agar - ULTRAPURE from GE Healthcare, formerly Amersham Biosciences
Biology Products: