Navigation Links
Mannitol boosts effectiveness of potential cord blood treatment for cerebral palsy in lab animals
Date:6/1/2010

were administered a variety of post-treatment movement tests and that those receiving the combination treatment instead of HUCB alone or mannitol alone demonstrated the most motor improvement.

"Our results indicate a pivotal role played by mannitol permeabilization of the blood-brain barrier," Dr. Borlongan explained.

Since the neonatal study animals receiving the combined HUCB cells and mannitol exhibited the most robust neurotrophic factor up-regulation, the study also suggests that even the immature blood-brain barrier needs to be permeabilized to facilitate entry by HUCB and to promote trophic factor effects, added Dr. Borlongan. The long-held view is that young animals display immature, not fully developed blood-brain barriers. However, the researchers demonstrated that manipulating the immature barrier is still required to gain improved access of therapeutic substances from peripheral circulation to the brain.

"Also, the therapeutic effects were achieved without immunosuppression, which is often accompanied by harmful side effects," said Dr. Borlongan.

Previous work by the research team demonstrated that grafted cells need not cross the blood-brain barrier to rescue the injured brain in adult stroke-modeled animals. In those studies mannitol helped facilitate the entry of growth factors secreted by the grafted cells.

"Our present findings extend the usefulness of blood-brain barrier permeabilization in facilitating cell therapy for treating neonatal brain injury and potentially cerebral palsy," concluded Dr. Borlongan.


'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida (USF Health)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Less is more when restraining calories boosts immunity
2. Single gene dramatically boosts yield, sweetness in tomato hybrids, CSHL-Israeli study finds
3. Ritalin boosts learning by increasing brain plasticity
4. An apple a day? Study shows soluble fiber boosts immune system
5. World-class protection boosts Australias Great Barrier Reef
6. Supplementing babies formula with DHA boosts cognitive development
7. High-tech vehicle design boosts emergency rescue capacity
8. Faculty of Translational Medicine boosts support for biomedical researchers
9. ESAs Earth observation missions: Sharing teams and facilities boosts efficiency
10. Late motherhood boosts family lifespan
11. Major NSF grant boosts UNH research on hormonal genomics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mannitol boosts effectiveness of potential cord blood treatment for cerebral palsy in lab animals
(Date:4/2/2015)... April 2, 2015 Fingerprint Cards ... sensor FPC1025 from the distributor World Peace Industrial Group ... Q2 2015 although the major part of the shipments ... be used by smartphone manufacturers in China ... included in the communicated revenue guidance of + 1 000 ...
(Date:3/31/2015)... YORK , March 31, 2015   Guidepoint ... the launch of the Post-Surgical Pain Management TRACKER, part ... products tracking usage trends in the medical device and ... access to data including treatment volumes, market share, and ... the pain associated with joint surgery. The ...
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ( ... Voice Biometrics - Global Strategic Business Report" report to their ... and Voice Biometrics in US$ Thousands by the following Segments: Face ... the US, Canada , Japan ... Middle East & Africa ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... The Institute for Genomics and Systems Biology (IGSB), a joint ... Laboratory and the University of Chicago, has acquired two new ... quickly and broadly. "Sequencing used to be like ... but not the rough," said IGSB Director Kevin White. "It ...
... The appointment of James Watson as Director ... an explosive development of research at Cold Spring Harbor ... of investigators with diverse scientific interests. In a ... scientists involved tell the stories of research carried out ...
... in the current issue of the online journal ... seizures and behavioral abnormalities in California sea lions can ... fetus. The findings follow an analysis earlier this year ... Center that showed this brain disturbance to be a ...
Cached Biology News:Argonne-University of Chicago joint venture bolsters genomic sequencing capabilities 2Watson-inspired innovation in research at Cold Spring Harbor Laboratory 2Domoic acid from toxic algal blooms may cause seizures in California sea lions 2
(Date:4/28/2015)... 28, 2015 According to a 2013 ... patients receive medical treatment from burn injuries per year. ... injury, extensive formation of scars with subsequent contractures remains ... for which there is no adequate treatment. Contractures are ... movement and can cause permanent deformity. , Synedgen ...
(Date:4/28/2015)... 2015 Dr. Harton will be responsible ... service operations across the products of Fertility Authority.com, EggBanxx, ... and only FDA-cleared test to use time lapse imaging ... selection during IVF. , Dr. Harton has joined Progyny ... Sciences, including both laboratory management and IVF practice management ...
(Date:4/28/2015)... Reproductive endocrinologist Dr. Kaylen Silverberg , on the ... in this country, testified on behalf of House Bill ... in the nation to consider creating a clearinghouse to connect ... to receive them. , Infertility affects over 7.3 million couples ... of the few medical diseases that is curable, the treatment ...
(Date:4/27/2015)... April 27, 2015  For about a century, ... their ability to utilize and catabolize glucose at ... cells is called the ,Warburg phenomenon", that is ... high oxygen presence, leading to enhanced lactate generation. ... still choose glucose fermentation. A variety of such ...
Breaking Biology Technology:Synedgen Burn Treatment Results Presented at Premier Wound Conference 2Synedgen Burn Treatment Results Presented at Premier Wound Conference 3Progyny Appoints Gary Harton as Group Senior Vice President, Commercial Development 2Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 2Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 3Study Indicates Cancer Cells Alter Glucose Metabolism to Enhance Energy Production and Cell Growth 2
... , , , , Multiporator / Electroporator 2510 , , , ... Transformation Protocol , Protocol No. 4308 915.502 12/2001 , ... , , , , ... , Cell type , Bacteria, gram ...
... Plasmid , Mini Kit , ... James Griffith and Kim Vollmer , James Griffith, ... Instruments, Biosytems Application Lab, Westbury, , NY , , ... , Cosmids are commonly used vectors in the lab, providing the ...
... , , , , Other important parameters for optimizing electroporation., , , , ... , , Pulse length , ... field pulses , Adjustment , of ... , Influence , of temperature , ...
Cached Biology Technology:Agrobacterium tumefaciens 2Isolation of Cosmids using Eppendorf's Perfectprep Plasmid , Mini Kit 2Isolation of Cosmids using Eppendorf's Perfectprep Plasmid , Mini Kit 3Isolation of Cosmids using Eppendorf's Perfectprep Plasmid , Mini Kit 4Isolation of Cosmids using Eppendorf's Perfectprep Plasmid , Mini Kit 5
The thermal printer, 120 V, is used to record fluorescence data acquired with the VersaFluor fluorometry systems. The printer includes a cable and power adaptor....
This thermal printer, 120 V, provides a permanent record of the preprogrammed method and run data for the PROTEAN IEF cell. Includes cable and power adaptor....
... The iCycler thermal cycler with 384-well ... amplification (PCR) applications. It is equipped with ... samples) and features algorithm temperature monitoring and ... for small sample volumes. It includes the ...
Request Info...
Biology Products: