Navigation Links
Manipulating serotonin can promote healthy repair in chronic liver disease
Date:11/28/2011

In liver disease, extent of tissue damage depends on the balance between the generation of scar tissue and the regeneration of new liver cells. In a significant minority of people who get injury to their organs instead of repairing them, they form scars. This can progress to chronic liver disease and cirrhosis where the scarring is so extensive the liver is unable to clean blood or produce vital hormones and clotting factors. Liver scars also provide an ideal environment for the development of cancers.

Publishing in Nature Medicine and showcased in Nature Research Highlights, the paper describes how working in mouse models the team were able to tip this balance to favour healthy tissue regeneration and block scarring by manipulating the actions of serotonin - the "happy" drug.

Normally when a liver is injured by a virus such as Hepatitis C or B, by alcohol, environmental factors or by a metabolic or autoimmune condition specialised blood cells known as platelets make general repairs and secrete serotonin.

However, the team found that when scar-forming cells - Hepatic stellate cells (HSC) are present they are instructed by the serotonin to make more scar tissue and switch off the healthy regeneration.

Identifying the receptor called 5-HT2B through which serotonin instructs the scar forming cells to switch off regeneration, they found that this resulted in less scarring and more regeneration.

Of the work funded by the Medical Research Council and the Wellcome Trust, lead author, Professor Derek Mann said; "These are promising results in mouse models of liver disease and suggest that drugs targeting 5-HT2B , which are currently in clinical trials for mood disorders and pulmonary hypertension might also have an application in the treatment of chronic liver disease."

The group believe the mechanism may also be found in other organs and offers an exciting opportunity for study in the future.


'/>"/>

Contact: Karen Bidewell
derek.mann@ncl.ac.uk
44-191-222-7850
Newcastle University
Source:Eurekalert

Page: 1

Related biology news :

1. Manipulating plants circadian clock may make all-season crops possible
2. Manipulating molecules for a new breed of electronics
3. Model developed for manipulating vitamin D levels in calves
4. Gene exchange common among sex-manipulating bacteria
5. The medium is the message: Manipulating salmonella in spaceflight curtails infectiousness
6. Serotonin plays role in many autism cases, studies confirm
7. Gestational diabetes linked to serotonin and dietary protein
8. Inhibiting serotonin in gut could cure osteoporosis
9. Lack of happiness hormone serotonin in the brain causes impaired maternal behavior in mice
10. Researchers iron out new role for serotonin
11. Biodiversity can promote survival on a warming planet
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... , March 21, 2017 Optimove ... used by retailers such as 1-800-Flowers and AdoreMe, ... — Product Recommendations and Replenishment. Using Optimove,s machine learning ... personalized product and replenishment recommendations to their customers ... on predictions of customer intent drawn from a ...
(Date:3/13/2017)... Future of security: Biometric Face Matching software  Continue ... ... to match face pictures against each other or against large databases. The recognition ... ... software for biometric Face Matching on the market. The speed is at 100 ...
(Date:3/6/2017)... MATEO, Calif. , March 6, 2017 /PRNewswire/ ... marketing and sales technology, today announced Predictive Sales ... solution for infusing actionable sales intelligence into Salesforce. ... to automatically enable their sales organizations with deep ... messages that allow for intelligent engagement. Predictive Sales ...
Breaking Biology News(10 mins):
(Date:3/30/2017)... In today,s pre-market research, Stock-Callers.com ... Corp. (NYSE: XON), Progenics Pharmaceuticals Inc. (NASDAQ: PGNX), and ... an article on Barron,s, Credit Suisse upgraded its rating on ... 21 st , 2017. These stocks research reports can be ... ...
(Date:3/29/2017)... Texas, March 29, 2017  Vermillion, Inc. (NASDAQ: ... disease, reported on its results for the fourth ... "2016 marked a pivotal year for ... guideline inclusion, international distribution agreements, major reimbursement progress ... network payer agreements. In addition we cleared our ...
(Date:3/29/2017)... N.J. and PETACH TIKVAH, ...  BrainStorm Cell Therapeutics Inc. (NASDAQ: BCLI), ... technologies for neurodegenerative diseases, announced financial results ... "2016 was a highly successful ... important achievements and significant progress made on ...
(Date:3/29/2017)... ... March 29, 2017 , ... On the heels of the globally recognized ... Travel has announced that it will manage travel services for its 500th clinical trial ... the United States and Europe to offer travel management services specifically for clinical trials ...
Breaking Biology Technology: