Navigation Links
Manipulating serotonin can promote healthy repair in chronic liver disease
Date:11/28/2011

In liver disease, extent of tissue damage depends on the balance between the generation of scar tissue and the regeneration of new liver cells. In a significant minority of people who get injury to their organs instead of repairing them, they form scars. This can progress to chronic liver disease and cirrhosis where the scarring is so extensive the liver is unable to clean blood or produce vital hormones and clotting factors. Liver scars also provide an ideal environment for the development of cancers.

Publishing in Nature Medicine and showcased in Nature Research Highlights, the paper describes how working in mouse models the team were able to tip this balance to favour healthy tissue regeneration and block scarring by manipulating the actions of serotonin - the "happy" drug.

Normally when a liver is injured by a virus such as Hepatitis C or B, by alcohol, environmental factors or by a metabolic or autoimmune condition specialised blood cells known as platelets make general repairs and secrete serotonin.

However, the team found that when scar-forming cells - Hepatic stellate cells (HSC) are present they are instructed by the serotonin to make more scar tissue and switch off the healthy regeneration.

Identifying the receptor called 5-HT2B through which serotonin instructs the scar forming cells to switch off regeneration, they found that this resulted in less scarring and more regeneration.

Of the work funded by the Medical Research Council and the Wellcome Trust, lead author, Professor Derek Mann said; "These are promising results in mouse models of liver disease and suggest that drugs targeting 5-HT2B , which are currently in clinical trials for mood disorders and pulmonary hypertension might also have an application in the treatment of chronic liver disease."

The group believe the mechanism may also be found in other organs and offers an exciting opportunity for study in the future.


'/>"/>

Contact: Karen Bidewell
derek.mann@ncl.ac.uk
44-191-222-7850
Newcastle University
Source:Eurekalert

Page: 1

Related biology news :

1. Manipulating plants circadian clock may make all-season crops possible
2. Manipulating molecules for a new breed of electronics
3. Model developed for manipulating vitamin D levels in calves
4. Gene exchange common among sex-manipulating bacteria
5. The medium is the message: Manipulating salmonella in spaceflight curtails infectiousness
6. Serotonin plays role in many autism cases, studies confirm
7. Gestational diabetes linked to serotonin and dietary protein
8. Inhibiting serotonin in gut could cure osteoporosis
9. Lack of happiness hormone serotonin in the brain causes impaired maternal behavior in mice
10. Researchers iron out new role for serotonin
11. Biodiversity can promote survival on a warming planet
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... presented Beaumont Health System with prestigious, competitive research ... athletic and nonathletic injuries. , The American ... grant to fund stem cell-based research that could ... ruptured knee anterior cruciate ligament, or ACL. According ... cruciate ligament injury is the over-stretching or tearing ...
(Date:4/22/2014)... a trip to Asia to coordinate with allies ... officials at the Office of Naval Research (ONR) ... (APTEP) as an example of strong and growing ... in the region. , The APTEP program, centered ... supports the development of alternative energy technologies. It ...
(Date:4/22/2014)... how communities can protect themselves from worsening storms. ... New England and the Midwest providing practical and ... goal is to help communities begin the steps ... of Syntectic International, Portland, OR. "It,s important because ... beyond feeling paralyzed from the lack of local ...
Breaking Biology News(10 mins):Beaumont awarded grants to study sports-related injury treatment, improve recovery 2Full power: Alternative energy partnerships flourish in Asia 2Full power: Alternative energy partnerships flourish in Asia 3Minnesota projects offer hope and practical help to communities facing more extreme storms 2
... staff scientist at Carnegie,s Department of Embryology, has ... American Academy of Microbiology. Fellows are annually elected ... their records of scientific achievement and original contributions ... single-celled yeast Saccharomyces cerevisiae , Koshland has ...
... bomb plot was uncovered in London in August 2006, ... (S&T) looked to to find ways to not only ... to figure out what those liquids are. Now, S&T-sponsored ... possible solution. They have successfully tested a liquid ...
... CSC (NYSE: CSC ) announced today that ... Operations and Support Services Unrestricted contract by the Department ... indefinite-delivery/indefinite-quantity (IDIQ) contract covers a broad range of services, ... of BTF business and program units. The contract has ...
Cached Biology News:Carnegie's Doug Koshland elected Fellow of the American Academy of Microbiology 2Good liquid, bad liquid 2CSC Awarded Department of Defense Biometrics Contract 2
(Date:1/14/2014)... The largest international professional organization of scientists ... derivatives thereof has endorsed an educational program that ... challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural Product ...
(Date:1/14/2014)... In recent years, growing suspicion about the ... development and promotion has led to unprecedented levels of ... concerns about the insidious impact of commercialization of research, ... to the world’s biggest pharmas for illegal marketing activities, ...
(Date:1/14/2014)... Jan. 14, 2014   Kinaxis ®, provider of RapidResponse ... sales and operations planning ( S&OP ) service, is proud ... , which will be held at the Hilton San Diego ... Kinaxis customer Elisabeth Kaszas , Director of Supply Chain ...
(Date:1/14/2014)... NY (PRWEB) January 14, 2014 During the ... now known as “The Doctor’s Plague.” In this time period, ... hands. This led, at times, to the death of vulnerable ... today don’t know that they may be unwittingly transmitting herpes ...
Breaking Biology Technology:World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... - New Progression-Free Survival Data Support Picoplatin ... for Metastatic Castration-Resistant Prostate Cancer -- Results ... of Clinical Oncology,s 2009 Genitourinary Cancers Symposium ... Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ...
... China, Feb. 25 /PRNewswire-Asia-FirstCall/ -- 3SBio Inc. (Nasdaq:, ... focused on researching,developing, manufacturing and marketing biopharmaceutical products, ... the fourth quarter and,full year ended December 31, ... 11, 2009. , Following ...
... and Sunflower Oils drive better restaurant menu optionsINDIANAPOLIS, Feb. ... significant milestone in North America with the reduction of ... fats over the past three years. Since the market ... by Dow AgroSciences, have replaced more than 340 million ...
Cached Biology Technology:Poniard Pharmaceuticals Announces New Efficacy and Safety Data from a Phase 2 Picoplatin Trial in Patients with Prostate Cancer 2Poniard Pharmaceuticals Announces New Efficacy and Safety Data from a Phase 2 Picoplatin Trial in Patients with Prostate Cancer 3Poniard Pharmaceuticals Announces New Efficacy and Safety Data from a Phase 2 Picoplatin Trial in Patients with Prostate Cancer 4Poniard Pharmaceuticals Announces New Efficacy and Safety Data from a Phase 2 Picoplatin Trial in Patients with Prostate Cancer 53SBio Inc. to Report 2008 Fourth Quarter and Full Year Earnings on March 11, 2009 2Heart Health Month Milestone: Half a Billion Pounds of Bad Fats Eliminated From North American Diet 2Heart Health Month Milestone: Half a Billion Pounds of Bad Fats Eliminated From North American Diet 3
Recombinant Rat Leptin, CF...
delta-like 1 homolog (Drosophila)...
... 71-18 mutS and ES1301 mutS are mismatch ... of these strains prevents repair of the ... high mutation efficiencies and making them helpful ... Altered Sites II Mutagenesis Systems. Both ES1301 ...
Request Info...
Biology Products: