Navigation Links
Manipulating chromatin loops to regulate genes may offer future treatments for blood diseases
Date:6/7/2012

In exploring how proteins interact with crucial DNA sequences to regulate gene activity, researchers have shed light on key biological events that may eventually be manipulated to provide new disease treatments.

Within a cell's nucleus, regulatory elements in DNA called promoters and enhancers communicate with each other in carrying out gene activity, often over large genomic distances, hundreds of thousands of chemical bases apart from each other in chromosomes. As these elements physically contact each other, the intervening DNA sequences bend into loops made of chromatin fiberthe substance of chromosomes.

"Many researchers, including ourselves, have shown that chromatin looping is widespread during gene expression," said study leader Gerd A. Blobel, M.D., Ph.D., holder of the Frank E. Weise III Endowed Chair in Pediatric Hematology at The Children's Hospital of Philadelphia. "However, many details remain uncertaineven whether chromatin loops are a cause or effect of gene transcription. Our current study investigated some of these fundamental questions."

Blobel and first author Wulan Deng, a Ph.D. student at the University of Pennsylvania, are publishing their study in the June 8, 2012 print edition of Cell.

The study focused on gene transcriptionthe fundamental process by which information encoded in a gene's DNA is converted into RNA before the RNA information is translated into a protein.

Blobel and Deng used blood-forming cells in mice, studying a portion of DNA called the beta-globin locus that expresses part of the hemoglobin molecule. The study team already knew that a chromatin loop forms when a distant enhancer touches the promoter in the beta-globin gene and gives rise to gene expression. They did not know all the proteins that were necessary to generate chromatin loops, nor exactly how such proteins functionally interact with other proteins during gene transcription.

The study tea
'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Crystal structure of archael chromatin clarified in new study
2. Law that regulates shark fishery is too liberal: UBC study
3. Gut microbiota regulates bile acid metabolism
4. Planarian genes that control stem cell biology identified
5. Culprit behind unchecked angiogenesis identified
6. Researchers identify genes that may help in ovarian cancer diagnosis and prognosis
7. Study finds peoples niceness may reside in their genes
8. Direct transfer of plant genes from chloroplasts into the cell nucleus
9. Large international study finds memory in adults impacted by versions of 4 genes
10. BUSM researchers identify genes that influence hippocampal volume
11. International team uncovers new genes that shape brain size, intelligence
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Manipulating chromatin loops to regulate genes may offer future treatments for blood diseases
(Date:12/22/2014)... SHELTON, Conn. , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... a biometric authentication company focused on the growing mobile commerce ... consultant, Apollo Robbins for the 2015 International CES ... Apollo Robbins will be at the NXT-ID booth ...
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ( ... Market Monitor: North America Perimeter Security Systems Market" report ... The North American perimeter security market is estimated ... 2019. Although the U.S. market holds a larger share in ...
(Date:12/17/2014)... , Dec. 15, 2014 The Defense Logistics Agency ... detect and prevent counterfeit microcircuits from entering into its ... an in-house microcircuit anti-counterfeit initiative dubbed DNA marking. The ... increasing their reliability throughout the supply chain. The new ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... Molecular and Cellular Biology is pleased to announce it ... Foundation for a unique Advanced Life Sciences Training Program. ... conference in Denver in July 2013 for all five ... since its inception in 2008. The Fellows Program is ...
... of infection in some hospital wards varies dramatically according ... A University of Leeds-led team studied airflow in a ... two rows of up to 30 bedsby using tracer ... found ventilation in the ward was generally good when ...
... PHOENIX, Ariz. April 16, 2013 Male circumcision reduces ... help explain why circumcision offers men some protection against HIV, ... Institute (TGen). Removing the foreskin caused a significant shift ... to a study published today by the online journal ...
Cached Biology News:Keystone Symposia announces grant from Alfred P. Sloan Foundation 2Energy efficiency could increase infection risks in hospital wards 2Energy efficiency could increase infection risks in hospital wards 3TGen-led study discovers dramatic changes in bacteria following male circumcision 2
(Date:1/22/2015)... , Jan. 22, 2015  Transwestern | RBJ today announces the ... office space for Shire a leading biopharmaceutical company, at Two ... | RBJ,s Robert Richards , president, and Brian ... for the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... January 22, 2015 Crystal Diagnostics (CDx) Xpress ... it has received AOAC-PTM Certifications for the six non-O157 Shiga ... O145; collectively referred to as STEC or the “Big-6”) as ... forming unit (cfu) per 325 g of raw ground beef ...
(Date:1/22/2015)... Wilmington, DE (PRWEB) January 22, 2015 ... the Pistoia Alliance, which helps companies check the legal ... set to expand to China. , As their ... companies are globally adopting software solutions built as a ...
(Date:1/22/2015)... SAN DIEGO , Jan. 22, 2015   ... company, and Sequenom, Inc. (NASDAQ: SQNM ... a development agreement for next generation noninvasive prenatal ... Cypher,s genome interpretation technology, called Mantis™, to advance ...
Breaking Biology Technology:Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Global Compliance Service for Controlled Substances to Expand to China 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4
... , ... SVA),a leading developer and provider of vaccines, announced today ... Sinovac (Dalian) Vaccine,Technology Co., Ltd. (Sinovac Dalian). The JV ... contribute its expertise,and experience in developing and commercializing world-class ...
... , SAN DIEGO, Nov. 25 Ardea Biosciences, Inc. (Nasdaq: ... president and chief executive officer, will present at the Piper ... as follows:,Piper Jaffray 21st Annual Health Care Conference,Date: ... 2:00 p.m. Eastern Time,Location: The New York ...
... , HOUSTON, Nov. 24 IES ... and communications systems and services for the commercial, industrial and ... been awarded a contract from Manhattan Torcon JV to install ... replacement facility at the U.S. Army Medical Research Institute of ...
Cached Biology Technology:Sinovac Establishes Joint Venture to Expand Human-Use Vaccine Development and Manufacturing Capabilities 2Sinovac Establishes Joint Venture to Expand Human-Use Vaccine Development and Manufacturing Capabilities 3Ardea Biosciences to Present at the Piper Jaffray 21st Annual Health Care Conference 2Integrated Electrical Services Awarded Contract to Provide Electrical Systems for U.S. Army Medical Research Institute of Infectious Diseases 2
sodium channel, nonvoltage-gated 1 alpha,...
MOUSE ANTI HUMAN B-CELLS (FMC7):FITC Immunogen: HRIK cells - Human B-Lymphoblastoid line...
RABBIT ANTI PARATHION...
Similar to proteasome (prosome, macropain) 26S subunit, ATPase, 1 Antigen: Recombinant Protein...
Biology Products: