Navigation Links
Manipulated gatekeeper: How viruses find their way into the cell nucleus
Date:10/3/2011

This release is available in German.

They have been around since the dawn of time and are a model of evolutionary success: viruses. Viruses are extremely adaptable but they have a problem: They cannot reproduce, so they smuggle their genes into suitable host cells. In the case of some viruses, the viral DNA has to enter the cell nucleus to reproduce. This has been known for almost 50 years. We know, for instance, that the adenovirus disassembles its protein shell in the first step. Just how the DNA is exposed and infiltrates the host cell, however, remained unclear despite decades of research.

A research group headed by Urs Greber, a cell biologist at the University of Zurich, has now managed to clear up these points. As the scientists recently revealed in the journal Cell Host & Microbe, viruses use the cell's own mechanisms. The adenovirus latches onto a gatekeeper molecule, which sits on the nuclear pore complex in the nucleus envelope and controls the passage in and out of the nucleus. Another protein in the nuclear pore complex binds and activates a motor protein from the kinesin family, which regulates the transport of substances near the nucleus.

Virus DNA uncoated with aid of host cell

"The motor protein is in an active condition, can bind to micro-tubules and migrate along them," says Professor Greber, explaining his team's observations. And the docked virus uses precisely this situation for its purposes. The virus binds to the kinesin and uses the energy of the motor to disrupt its own shell, which exposes the virus DNA and prepares it for transport into the nucleus. The action of the activated motor has another effect, too: The nuclear pore ruptures and becomes markedly bigger, which enables the viral DNA to enter the cell nucleus more easily. Surprisingly, the cell repairs the defective nuclear pore s
'/>"/>

Contact: Urs Greber
urs.greber@imls.uzh.ch
41-446-354-841
University of Zurich
Source:Eurekalert

Page: 1 2

Related biology news :

1. XMRV, related viruses not confirmed in blood of healthy donors or chronic fatigue syndrome patients
2. Watching viruses friend a network
3. Decade-long study reveals recurring patterns of viruses in the open ocean
4. Scientists copy the ways viruses deliver genes
5. Humabs discovers the first antibody to neutralize both group 1 and group 2 influenza A viruses
6. Scavenger cells accomplices to viruses
7. New laser technology could kill viruses and improve DVDs
8. When viruses infect bacteria
9. A planet of viruses
10. David and Goliath viruses shed light on the origin of jumping genes: UBC study
11. Using artificial, cell-like honey pots to entrap deadly viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... exists as five strains, none of which have approved ... Sudan ebolavirus (SUDV). Although not the strain currently devastating ... recently as 2012. In a new study appearing in ... report a possible therapy that could someday help treat ... Jonathan Lai and colleagues explain that about 50-90 percent ...
(Date:8/27/2014)... Now that health advocates, campaigns against trans-fats have ... additive, they,re taking aim at sugar for its ... and policymakers are still wrangling over the best ... according to an article in Chemical & ... of the American Chemical Society. , In the ...
(Date:8/27/2014)... be found in both unprocessed and processed foods. Over ... been infected with Listeria from processed food, ... is notoriously difficult to fight because it has an ... surroundings, says Associate Professor Birgitte Kallipolitis, University of Southern ... and Molecular Biology, she has published a study, which ...
Breaking Biology News(10 mins):Potential therapy for the Sudan strain of Ebola could help contain some future outbreaks 2Researchers discover why Listeria bacterium is so hard to fight 2Researchers discover why Listeria bacterium is so hard to fight 3
... Cervical ripening that instigates preterm labor is distinct from ... researchers at UT Southwestern Medical Center have found. ... ripening and remodeling is likely just an accelerated version ... ripening is caused primarily by activation of inflammatory responses. ...
... It is a common perception that bigger, stronger, faster ... competing with other organisms in a given community. ... that in some structured communities, organisms increase their chances ... that allows competitors to survive as well, a sort ...
... is good Nature is full of mimicscreatures that ... animals. However, some mimics imitate their models more convincingly than ... to be a bad mimic. The research looked at three ... of accuracy, aggressive and bad-tasting ants. All of the mimics ...
Cached Biology News:Researchers find process of cervical ripening differs between term and preterm birth 2Bacteria develop restraint for survival in a rock-paper-scissors community 2News tips from the July issue of the American Naturalist 2News tips from the July issue of the American Naturalist 3
(Date:8/27/2014)... , Aug. 27, 2014 Research ... "Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014" ... Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 ... state of the global isotope ratio mass spectrometer industry. ... the industry including definitions, classifications, applications and industry chain ...
(Date:8/27/2014)... 27, 2014 After the boom of ... the next beverage craze is going to be the ... formulators can use Stress Relief energy pattern which can ... making of a beverage, including minerals, herbs and liquids. ... channeling that power into rapid recovery and helping to ...
(Date:8/26/2014)... believe is the thinnest-possible semiconductor, a new class ... atoms thick. , The University of Washington researchers ... materials can be connected in an atomically seamless ... be the basis for next-generation flexible and transparent ... technologies. , "Heterojunctions are fundamental elements of electronic ...
(Date:8/26/2014)... engineers from Singapore has successfully piloted the world,s ... communications. , With the weight of payloads being ... lightweight, low power-consuming, wireless communication system to do ... been a challenge for system designers. , The ... Nanyang Technological University in Singapore launched VELOX-I, which ...
Breaking Biology Technology:Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2Stress Relief: 1 Way to De-Stress Your Beverage Formula 2Stress Relief: 1 Way to De-Stress Your Beverage Formula 3Stress Relief: 1 Way to De-Stress Your Beverage Formula 4Scientists craft atomically seamless, thinnest-possible semiconductor junctions 2ZigBee in the Sky 2
... 8, 2011 Health Care Compliance Strategies, Inc. (HCCS) ... Critical Care Nurses (AACN), to deliver a series of ... delivered on HCCS Learning Management Systems.  This training includes ... Orientation (ECCO) and Essentials of Nurse Manager ...
... of Standards and Technology (NIST) have created a tunable superconducting ... photon (particle of light) in two frequencies, or colors, at ... the quantum world, is a chip-scale, microwave version of a ... sends a photon into either of two possible paths across ...
... For the first time since stem cells were discovered ... blood stem cell in its purest form – as ... blood system. This breakthrough opens the door to harnessing ... and other debilitating diseases more effectively. The ...
Cached Biology Technology:HCCS Partners with American Association of Critical Care Nurses (AACN) to Offer Nurse Training 2HCCS Partners with American Association of Critical Care Nurses (AACN) to Offer Nurse Training 3NIST prototype 'optics table on a chip' places microwave photon in 2 colors at once 2"Pure" Human Blood Stem-Cell Discovery Opens Door to Expanding Cells for More Clinical Use 2"Pure" Human Blood Stem-Cell Discovery Opens Door to Expanding Cells for More Clinical Use 3
... used to screen blots of mini format (8 ... up to 40 different antibodies or sera without ... apparatus includes a base plate, 2 separate, detachable ... x 7 cm membranes, and gaskets and clamps ...
Fingerprinting II Informatix cluster analysis is an optional module that adds dendrogram and phylogenetic tree construction, cluster and group significance, and congruence of techniques functions to ...
Fingerprinting II dimensioning techniques is an optional module that adds principal component analysis, multidimensional scaling, discriminant analysis and MANOVA, and self-organizing maps to the Fin...
Fingerprinting II cluster analysis is an optional module that adds dendrogram and phylogenetic tree construction, cluster and group significance, and congruence of techniques functions to the Fingerp...
Biology Products: