Navigation Links
Manchester's 'first step' to perfect drug combinations
Date:10/23/2011

robotics in the laboratory, the scientists were able to find effective combinations and then refine them as many times as necessary to find ideal combinations.

Ultimately, they hope this will lead to the development of tailored therapies for treating inflammation.

Professor Kell, who is also Chief Executive of the Biotechnology and Biological Sciences Research Council, said: "Most diseases have complex causes. This makes their analysis a problem of systems biology, and to find novel therapies multiple targets need to be attacked at once.

"We have devised a strategy, based on Darwinian evolution, to make this considerably easier. Although our immediate interest is inflammation and conditions such as stroke, our approach is universal and is thus applicable to all complex diseases."

Another advantage of choosing ideal drug combinations is that it allows patients to take smaller doses, which reduces potential toxicology concerns.

Professor Kell and his team worked with computer scientists at the University to create the programme. Professor Pedro Mendes explains: "Our experiments were guided by software that is based on an evolutionary algorithm. The algorithm suggests new drug combinations from previous ones by re-mixing their components much like the DNA of a child is a mix of that of their parents.

"The new drug combinations are then tested and the best are selected to continue generating new ones. In each experiment we tested 50 drug combinations, then the software would tell us which new ones to test in the next experiment."


'/>"/>

Contact: Daniel Cochlin
daniel.cochlin@manchester.ac.uk
44-161-275-8387
University of Manchester
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers generate first complete 3-D structures of bacterial chromosome
2. National Science Foundation makes first awards in Sustainability Research Coordination Program
3. The Worlds First Non Optical FBI Appendix F Certified Fingerprint Sensor
4. First genome-wide association study for dengue identifies candidate susceptibility genes
5. Scientists first to characterize barley plant-stem rust spore communication
6. Angel investor market stabilizes in first half of 2011, UNH Center for Venture Research finds
7. Uncharted territory: Scientists sequence the first carbohydrate biopolymer
8. Worms among first animals to surface after K-T extinction event, CU-led study finds
9. In bubble-rafting snails, the eggs came first
10. First NIH-funded personalized drug development center in US will focus on muscle disease
11. Pumice proposed as home to the first life forms: A new hypothesis in Astrobiology journal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Dec. 18, 2014  23andMe, Inc., the leading personal genetics company, ... differences in genetic ancestry of individuals from across ... arrived more than four hundred years ago, the ... for peoples from different continents. This study illuminates how American ...
(Date:12/17/2014)... BELVOIR, Va. , Dec. 15, 2014 The ... it easier to detect and prevent counterfeit microcircuits from ... agency started performing an in-house microcircuit anti-counterfeit initiative dubbed ... purchased microcircuits while increasing their reliability throughout the supply ...
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) has ... Market 2015-2019" report to their offering. ... trend upcoming in this market is the increasing demand ... in recording of patient data for quick and correct ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... 12, 2009 An international conference that will explore ... University May 25-29. It is being organized to coincide ... On the Origin of Species, (and the 200th anniversaryspecifically, ... Einstein of biology," says Ralph Pudritz, director of McMaster,s ...
... CITYUnraveling the genetics of social behavior and cognitive abilities, ... Institute for Biological Studies have traced the role of ... known as Williams Syndrome. Their results, published ... American Journal of Medical Genetics , suggest that ...
... -- The rangelands of Iran have one of the world,s ... technological developments and knowledge of the soil that has produced ... an increasing population of humans and livestock in the region ... suggests that the soil is rapidly degrading. With the land ...
Cached Biology News:2 genes influence social behavior, visual-spatial performance in people with Williams syndrome 22 genes influence social behavior, visual-spatial performance in people with Williams syndrome 3Preventing rangeland erosion: Developing better management practices in Iran 2
(Date:1/22/2015)... | RBJ today announces the firm brokered a long-term lease ... leading biopharmaceutical company, at Two Ledgemont Center in ... , president, and Brian Cohen , senior vice president, ... at 95 Hayden Ave. Photo - http://photos.prnewswire.com/prnh/20150122/170765 ...
(Date:1/22/2015)... Boulder, CO / Rootstown, OH (PRWEB) January 22, 2015 ... sensitive detection platform, announced today that it has received AOAC-PTM ... O26, O45, O1O3, O111, O121, and O145; collectively referred to ... (E. coli) O157, at 1 colony forming unit (cfu) per ...
(Date:1/22/2015)... 2015 Controlled Substance Compliance Services (CSCS), ... companies check the legal requirements around using controlled substances ... , As their international operations expand and become ... solutions built as a result of the first phase ...
(Date:1/22/2015)... Jan. 22, 2015   Cypher Genomics, Inc., ... (NASDAQ: SQNM ), the leading molecular ... next generation noninvasive prenatal tests (NIPT). Through this ... called Mantis™, to advance analysis of clinically-relevant fetal ...
Breaking Biology Technology:Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Global Compliance Service for Controlled Substances to Expand to China 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4
... Renewable Natural Gas ... and Other Waste Products, TARRYTOWN, N.Y., June 11 ... in the renewable bioenergy industry,will today mark the commencement ... a ground breaking ceremony. The Dublin, Texas,facility, owned and ...
... June 11 WellCentive today announced the ... is now a part of its,popular online ... Atlanta-based WellCentive (http://www.wellcentive.com ) provides ... registry system for,physicians, physician organizations, health insurance ...
... in Animal Models of ... Arthritis - ... SAN DIEGO, June 11 Ardea Biosciences, Inc.,(Nasdaq: RDEA ) today announced ... RDEA119, demonstrating,its potent activity in animal models of arthritis. In addition, the Company,will ...
Cached Biology Technology:Environmental Power Holds Ground Breaking Ceremony for Renewable Natural Gas Facility at Rio Leche Estates 2Environmental Power Holds Ground Breaking Ceremony for Renewable Natural Gas Facility at Rio Leche Estates 3Environmental Power Holds Ground Breaking Ceremony for Renewable Natural Gas Facility at Rio Leche Estates 4Environmental Power Holds Ground Breaking Ceremony for Renewable Natural Gas Facility at Rio Leche Estates 5WellCentive Launches New Secure Messaging Platform for Its Patient Registry System 2WellCentive Launches New Secure Messaging Platform for Its Patient Registry System 3Ardea Biosciences Presents Inflammation Program Data for Arthritis and Gout at 2008 Annual European Congress of Rheumatology 2Ardea Biosciences Presents Inflammation Program Data for Arthritis and Gout at 2008 Annual European Congress of Rheumatology 3Ardea Biosciences Presents Inflammation Program Data for Arthritis and Gout at 2008 Annual European Congress of Rheumatology 4Ardea Biosciences Presents Inflammation Program Data for Arthritis and Gout at 2008 Annual European Congress of Rheumatology 5
In Western blotting antibodies recognize 94 K protein band, which corresponds to S-layer protein...
High affinity antibodies recognizes HSP70 protein from human cardiac tissue. Could be used for Westerb blotting application, ELISA....
The VersArray hybridization chamber is used for manual (coverslip) hybridization of microarrays. The chamber accommodates 2 slides and is watertight to allow incubation of slides in a water bath. Dim...
... PROTECT FROM LIGHT. Useful in cell activation experiments when ... by TLC. Soluble in DMSO or EtOH. ... mM stock in DMSO is recommended. Microliter amounts of ... with rapid mixing (e.g. 10 μl into 5 ml ...
Biology Products: