Navigation Links
Manchester's 'first step' to perfect drug combinations
Date:10/23/2011

The researchers found a way of identifying ideal drug combinations from billions of others which would prevent inflammation from occurring.

The findings, published in Nature Chemical Biology, could be the first step in the development of new drug combinations to combat severe diseases and conditions.

Most non-infectious disease, such as cancer, stroke and Alzheimer's are worsened by inflammation, which is the body's natural defence mechanism.

Inflammation has evolved to help fight infection but can also be very damaging in long term disease, prolonging suffering and ultimately risking premature death.

After a stroke, the body reacts to the injury as if it were an infection, causing further damage. By blocking the inflammation, the chances of survival or higher quality of life following a stroke are thus greatly enhanced. This can be achieved by quickly and effectively identifying combinations of drugs which can be used together.

Existing 'clot-busting' stroke drugs are only effective if administered within three hours after the stroke often very difficult to achieve as people are often unaware they are having a stroke and even then do not completely solve the problem, often leaving sufferers with serious disabilities.

However, using ideal drug combinations the researchers suggest they can block inflammation and therefore greatly reduce the damage caused by non-communicable diseases such as stroke.

Although the researchers have initially concentrated on stroke, they believe the process can be applied to all drugs and for a huge variety of diseases.

The multi-disciplinary team of researchers, led by Professor Douglas Kell, Professor of Bioanalytical Science at The University of Manchester, developed an evolutionary computer programme which rapidly sifted through nine billion different combinations of potential drugs.

Sorting and testing 50 drug combinations at a time using robotics in the laboratory, the scientists were able to find effective combinations and then refine them as many times as necessary to find ideal combinations.

Ultimately, they hope this will lead to the development of tailored therapies for treating inflammation.

Professor Kell, who is also Chief Executive of the Biotechnology and Biological Sciences Research Council, said: "Most diseases have complex causes. This makes their analysis a problem of systems biology, and to find novel therapies multiple targets need to be attacked at once.

"We have devised a strategy, based on Darwinian evolution, to make this considerably easier. Although our immediate interest is inflammation and conditions such as stroke, our approach is universal and is thus applicable to all complex diseases."

Another advantage of choosing ideal drug combinations is that it allows patients to take smaller doses, which reduces potential toxicology concerns.

Professor Kell and his team worked with computer scientists at the University to create the programme. Professor Pedro Mendes explains: "Our experiments were guided by software that is based on an evolutionary algorithm. The algorithm suggests new drug combinations from previous ones by re-mixing their components much like the DNA of a child is a mix of that of their parents.

"The new drug combinations are then tested and the best are selected to continue generating new ones. In each experiment we tested 50 drug combinations, then the software would tell us which new ones to test in the next experiment."


'/>"/>

Contact: Daniel Cochlin
daniel.cochlin@manchester.ac.uk
44-161-275-8387
University of Manchester
Source:Eurekalert

Related biology news :

1. Researchers generate first complete 3-D structures of bacterial chromosome
2. National Science Foundation makes first awards in Sustainability Research Coordination Program
3. The Worlds First Non Optical FBI Appendix F Certified Fingerprint Sensor
4. First genome-wide association study for dengue identifies candidate susceptibility genes
5. Scientists first to characterize barley plant-stem rust spore communication
6. Angel investor market stabilizes in first half of 2011, UNH Center for Venture Research finds
7. Uncharted territory: Scientists sequence the first carbohydrate biopolymer
8. Worms among first animals to surface after K-T extinction event, CU-led study finds
9. In bubble-rafting snails, the eggs came first
10. First NIH-funded personalized drug development center in US will focus on muscle disease
11. Pumice proposed as home to the first life forms: A new hypothesis in Astrobiology journal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
(Date:6/2/2016)... , June 2, 2016 Perimeter ... Platforms, Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... market will generate revenues of $17.98 billion in 2016. ... DVTEL Inc, a leader in software and hardware technologies ...
Breaking Biology News(10 mins):
(Date:6/22/2016)... Cell Applications, Inc. and StemoniX announced ... up to one billion human induced pluripotent stem ... These high-quality, consistent stem cells enable researchers to ... more time doing meaningful, relevant research. This achievement ... process that produces affordable, reliable HiPSC for life ...
(Date:6/22/2016)... --  StockNewsNow.com , The Official MicroCap News Source™, today ... Pourhassan , President & CEO of CytoDyn Inc. (OTCQB: ... and potential commercialization of humanized monoclonal antibodies for the ... company,s website (see here: www.CytoDyn.com ). The video ... 2016, at the LD Micro Invitational in ...
(Date:6/22/2016)... ... , ... New light-based technologies that facilitate a “look inside” the human body ... compact, wearable devices for point-of-care diagnostics as well as powerful new systems that provide ... visionary future directions are detailed in a new open-access article by Antonio Pifferi and ...
(Date:6/22/2016)... and ALBANY, N.Y. , ... (Teewinot) and Albany Molecular Research, Inc. (NASDAQ: ... licensed Teewinot,s technology to produce and sell the ... The CBCA analytical standard is manufactured using Teewinot,s ... expression of cannabinoid biosynthetic genes in microorganisms for ...
Breaking Biology Technology: