Navigation Links
Malignant stem cells may explain why some breast cancers develop and recur
Date:8/16/2011

PORTLAND, Ore. Mutations that are found in stem cells could be causing some breast cancers to develop and may be the reason the disease recurs. These abnormal cells are likely controlling cell functions in the tumor and, given they are not targeted by chemotherapy and radiation, they enable the disease to recur.

The mutations were discovered in a study conducted by scientists and physicians at the Oregon Health & Science University Knight Cancer Institute. The study, which examined breast cancer cells removed during surgery, was recently published online in the Annals of Surgical Oncology.

"By studying normal and malignant cells that were collected from breast tissues removed during surgery, we were able to look at what is occurring in the body," said SuEllen J. Pommier, Ph.D., the lead author of the study and associate research professor in the division of surgical oncology at the OHSU Knight Cancer Institute.

Working with samples taken directly from surgeries made the findings in this study possible, Pommier said, because the biology of breast stem cells could be compared with their malignant counterparts in a way that hadn't been done before. The cultured cell lines used in most studies can't provide accurate information about normal breast stem cells.

The study, which was funded primarily by the Avon Foundation for Women, may prove that some current therapies that target mutations in the tumor won't be effective in stamping out the disease for some patients. It also suggests that more research should be done in two areas:

  • Determining the role of PIK3CA/AKT1 signaling mutations, which were found in 73 percent of the tumors in this study of fresh surgical specimens an occurrence rate that is much higher than previously detected in stored samples.
  • And, exploring the importance of the loss of CD24 expression, which previously was considered a requirement for breast cancer stem cells, but may not be a characteristic of all breast cancer stem cells.

Understanding the biology of individual tumors is the primary mission of the OHSU Knight Cancer Institute. "This study provided us with new insights into breast cancer stem cells and possibly into the earliest mutations. That information is crucial for developing treatments," Pommier added.


'/>"/>

Contact: Elisa Williams
willieli@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert  

Related biology news :

1. Professor discovers way to slow the growth of malignant melanoma
2. Viral life cycle of malignant catarrhal fever explained
3. Gorillas carry malignant malaria parasite, study reports
4. CSHL study shows that some malignant tumors can be shut down after all
5. Researchers find first evidence of virus in malignant prostate cells
6. Childhood eye tumor made up of hybrid cells with jumbled development
7. Stem cells central to pathogenesis of mature lymphoid tumors
8. Gladstone scientists offer new insight into the regulation of stem cells and cancer cells
9. A novel mechanism that regulates pro-inflammatory cells is identified
10. Researchers use human cells to engineer functional anal sphincters in lab
11. Researchers gain new insights into how tumor cells are fed
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Malignant stem cells may explain why some breast cancers develop and recur 
(Date:3/14/2016)... , March 14, 2016 NXTD ) ... mobile commerce market, announces the airing of a new series ... the week of March 21 st .  The commercials will ... its popular Squawk on the Street show. --> ... the growing mobile commerce market, announces the airing of a ...
(Date:3/10/2016)... PUNE, India , March 10, 2016 ... to a new market research report "Identity and Access ... SSO, & Audit, Compliance, and Governance), by Organization Size, ... Forecast to 2020", published by MarketsandMarkets, The market is ... to USD 12.78 Billion by 2020, at a Compound ...
(Date:3/9/2016)... , March 9, 2016  Crossmatch ® ... and enrollment solutions, today announced the addition of ... Altus multi-factor authentication platform. New contextual ... managers to step-up security where it,s needed most ... Washington, DC . --> ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... 2016 According to a ... "Separation Systems for Commercial Biotechnology Market - Global ... 2015 - 2023", the separation systems for commercial ... in 2014 and is projected to expand at ... to reach US$ 19,227.8 Mn in 2023. ...
(Date:4/28/2016)... April 28, 2016 The report ... Brayton Cryocoolers), Service (Technical Support, Product Repairs & Refurbishment, ... Global Forecast to 2022", published by MarketsandMarkets, the global ... by 2022, at a CAGR of 7.29% between 2016 ... Tables and 94 Figures spread through 159 Pages and ...
(Date:4/28/2016)... ... April 28, 2016 , ... Morris ... open house for regional manufacturers at its Maple Grove, Minnesota technical center, May ... Group, Chiron and Trumpf. Almost 20 leading suppliers of tooling, accessories, software ...
(Date:4/27/2016)... April 27, 2016 NanoStruck ... (OTCPink: NSKQB) ( Frankfurt : 8NSK) ... Pressemitteilung vom 13. August 2015 die Genehmigung von ... um zusätzliche 200.000.000 Einheiten auf 400.000.000 Einheiten zu ... bringen. Davon wurden 157.900.000 Einheiten mit dem ersten ...
Breaking Biology Technology: