Navigation Links
Malignant stem cells may explain why some breast cancers develop and recur

PORTLAND, Ore. Mutations that are found in stem cells could be causing some breast cancers to develop and may be the reason the disease recurs. These abnormal cells are likely controlling cell functions in the tumor and, given they are not targeted by chemotherapy and radiation, they enable the disease to recur.

The mutations were discovered in a study conducted by scientists and physicians at the Oregon Health & Science University Knight Cancer Institute. The study, which examined breast cancer cells removed during surgery, was recently published online in the Annals of Surgical Oncology.

"By studying normal and malignant cells that were collected from breast tissues removed during surgery, we were able to look at what is occurring in the body," said SuEllen J. Pommier, Ph.D., the lead author of the study and associate research professor in the division of surgical oncology at the OHSU Knight Cancer Institute.

Working with samples taken directly from surgeries made the findings in this study possible, Pommier said, because the biology of breast stem cells could be compared with their malignant counterparts in a way that hadn't been done before. The cultured cell lines used in most studies can't provide accurate information about normal breast stem cells.

The study, which was funded primarily by the Avon Foundation for Women, may prove that some current therapies that target mutations in the tumor won't be effective in stamping out the disease for some patients. It also suggests that more research should be done in two areas:

  • Determining the role of PIK3CA/AKT1 signaling mutations, which were found in 73 percent of the tumors in this study of fresh surgical specimens an occurrence rate that is much higher than previously detected in stored samples.
  • And, exploring the importance of the loss of CD24 expression, which previously was considered a requirement for breast cancer stem cells, but may not be a characteristic of all breast cancer stem cells.

Understanding the biology of individual tumors is the primary mission of the OHSU Knight Cancer Institute. "This study provided us with new insights into breast cancer stem cells and possibly into the earliest mutations. That information is crucial for developing treatments," Pommier added.


Contact: Elisa Williams
Oregon Health & Science University

Related biology news :

1. Professor discovers way to slow the growth of malignant melanoma
2. Viral life cycle of malignant catarrhal fever explained
3. Gorillas carry malignant malaria parasite, study reports
4. CSHL study shows that some malignant tumors can be shut down after all
5. Researchers find first evidence of virus in malignant prostate cells
6. Childhood eye tumor made up of hybrid cells with jumbled development
7. Stem cells central to pathogenesis of mature lymphoid tumors
8. Gladstone scientists offer new insight into the regulation of stem cells and cancer cells
9. A novel mechanism that regulates pro-inflammatory cells is identified
10. Researchers use human cells to engineer functional anal sphincters in lab
11. Researchers gain new insights into how tumor cells are fed
Post Your Comments:
Related Image:
Malignant stem cells may explain why some breast cancers develop and recur 
(Date:11/17/2015)...  Vigilant Solutions announces today that Mr. Dick ... --> --> Mr. ... partnership at TPG Capital, one of the largest global ... in revenue.  He founded and led TPG,s Operating Group, ... from 1997 to 2013.  In his first role, he ...
(Date:11/12/2015)... 12, 2015  Arxspan has entered into an ... Harvard for use of its ArxLab cloud-based suite ... The partnership will support the institute,s efforts to ... research information internally and with external collaborators. The ... managing the Institute,s electronic laboratory notebook, compound and ...
(Date:11/10/2015)... , Nov. 10, 2015 ... behavioral biometrics that helps to identify and verify ... Signature is considered as the secure and accurate ... identification of a particular individual because each individual,s ... accurate results especially when dynamic signature of an ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... -- Cepheid (Nasdaq: CPHD ) today announced that, ... Healthcare Conference in New York City ... outlook for the fourth quarter of 2015 and initiating ... term business model expectations. John Bishop , ... be the fastest growing company of the major market ...
(Date:12/1/2015)... 2015 ) ... U.K. Virology and Bacteriology Testing Market: Sales ... Supplier Shares by Test, Innovative Technologies, Competitive ... --> ) has announced ... and Bacteriology Testing Market: Sales and Volume ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... Global Stem Cells Group announced ... clinics in the cities of Arica and Iquique in northern Chile. The facilities are part ... offer the most advanced protocols and techniques in stem cell medicine to patients from around ...
(Date:11/30/2015)... 30, 2015  Culprits beware, a University at ... Jan Halámek, is taking crime scene fingerprint identification ...   -->   --> ... --> --> Halámek and ... a straightforward concept for identifying whether a culprit ...
Breaking Biology Technology: