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Malfunction of the respiratory epithelium is a cause of allergy?
Date:4/3/2009

llergic patients but not of healthy subjects. This kind of transport mechanisms are used by several viruses and bacteria when invading the epithelium and infecting patients", explains Professor Risto Renkonen (Haartman Institute, University of Helsinki and HUSLAB, Helsinki, Finland).

A systems biological approach was used in these studies, where data obtained concomitantly by several different methods is collected into a massive data warehouse allowing one to start analyzing the roles of different proteins and their networks in the pathogenesis of allergic reactions.

Reductionistic analyses, i.e., work focusing on one or only a few molecules are gradually replaced by systems approaches. The ability to discover new, etiologically relevant disease mechanisms is the major motivation for unbiased explorative approaches. The drawback of such top-down experiments is that they are very expensive and produce much more raw data than hypothesis-derived approaches thus generating an overflow of data. However, the urgent need to develop in silico data managing and analysis environments has been recognized by several research groups and biocompanies.


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Contact: Professor Risto Renkonen
risto.renkonen@helsinki.fi
358-405-535-219
University of Helsinki
Source:Eurekalert

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