Navigation Links
Male and female sex cell determination requires lifelong maintenance and protection
Date:5/22/2014

MINNEAPOLIS/ST. PAUL (May 22, 2014) The way in which the sex of an organism is determined may require lifelong maintenance, finds new research from the University of Minnesota. According to the study published today in the journal Developmental Cell, sex-specific transcription factors perform lifelong work to maintain sexual determination and protect against reprogramming of cells from one sex to the other.

Previous research at the University of Minnesota's Department of Genetics, Cell Biology, and Development showed sex determination is not permanent. Using a mouse model, researchers found the sex of gonadal cells those found in the ovaries or testes require maintenance throughout life. This research also showed loss of a single transcription factor can result in the transformation of male cells into female cells.

"DMRT1 in the testis and FOXL2 in the ovary have been identified as key transcription factors responsible for maintaining sexual differentiation. What we asked in this study was how the cells maintain sexual differentiation and why their sex determination requires continuous protection," said David Zarkower, Ph.D., principal author and director of the Developmental Biology Center at the University of Minnesota.

Zarkower's research team took a closer look at DMRT1 and determined it partners with the male fetal sex determination gene called Sox9 to maintain male sexual determination after birth in a mouse model. Part of that work includes silencing genes normally involved in the female fetal sex determination process. This discovery indicates lifelong sex determination maintenance requires a process related to prenatal sex determination.

Another notable discovery is DMRT1's ability to limit retinoic acid (RA) signaling, preventing RA from activating genes normally involved in female sex determination and female organ development.

"While RA signaling between cells is absolutely required for sperm production and male fertility, we found that RA also has a dark side. If DMRT1 is not there to act as a guardian of maleness, RA has the potential to activate genes driving male-to-female transdifferentiation," said Zarkower. "This shows cell signaling can transform the identities of the very cells that use it from male to female. We think other cell types may also require similar mechanisms allowing them to use critical signaling molecules without becoming reprogrammed."


'/>"/>
Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Related biology news :

1. Sexual conflict affects females more than males, says new research on beetles
2. Male or female?
3. In sex-reversed cave insects, females have the penises
4. Hormone in crab eyes makes it possible for females to mate and care for their young
5. White silk wrappings key to female spiders heart
6. Does it pay to be a lover or a fighter? It depends on how you woo females
7. Boost careers of female scientists: Make sure women help choose meeting speakers
8. Mating is the kiss of death for certain female worms
9. Multiple mates worth the risk for female prairie dogs
10. Different gene expression in male and female brains may help explain sex differences in brain disorder
11. Older siblings cells can be passed from female dogs to their puppies in the womb, MU researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/6/2017)... 6, 2017 Mintigo , the ... announced Predictive Sales Coach TM , its new ... intelligence into Salesforce. This unique AI application will ... organizations with deep knowledge of their customers and ... engagement. Predictive Sales Coach extends Mintigo,s existing customer ...
(Date:3/2/2017)... -- Australian stem cell and regenerative medicine company, ... agreement with the Monash Lung Biology Network, a consortia ... Department of Pharmacology at Monash University, Melbourne ... support the use of Cymerus™ mesenchymal stem cells (MSCs) ... is a chronic, long term lung condition recognised by ...
(Date:2/28/2017)...  EyeLock LLC, ein marktführendes Unternehmen im Bereich ... Lösung zur Iris-Erkennung auf der neuesten Mobilplattform ... dem Mobile World Congress 2017 (27. Februar ... 3, Stand 3E10, vorstellen. Der ... – eine Kombination aus Hardware, Software und ...
Breaking Biology News(10 mins):
(Date:3/24/2017)...   Sienna Biopharmaceuticals, Inc. , a privately held, ... Richard Peterson will join the company as ... who brings more than two decades of global financial ... retiring at the end of April but will continue ... Sienna from Novan, Inc., where he served as Chief ...
(Date:3/23/2017)... ... 2017 , ... AxioMed president, Jake Lubinski, describes the AxioMed ... deformed, which is identical to how the human discs work to distribute force. ... to its natural state along a hysteresis curve, exactly like a healthy human ...
(Date:3/23/2017)... DUBLIN , Mar 23, 2017 ... "Biorefinery Products: Global Markets" report to their offering. ... The ... from $466.6 Billion in 2016 at a CAGR of 8.9%, ... of energetic and non-energetic bioproducts into seven major product segments: ...
(Date:3/23/2017)... March 23, 2017  SeraCare Life Sciences, ... in vitro diagnostics manufacturers and clinical laboratories, ... first multiplexed Inherited Cancer reference material ... by next-generation sequencing (NGS). The Seraseq™ Inherited Cancer ... input from industry experts to validate the ...
Breaking Biology Technology: