Navigation Links
Male and female sex cell determination requires lifelong maintenance and protection
Date:5/22/2014

MINNEAPOLIS/ST. PAUL (May 22, 2014) The way in which the sex of an organism is determined may require lifelong maintenance, finds new research from the University of Minnesota. According to the study published today in the journal Developmental Cell, sex-specific transcription factors perform lifelong work to maintain sexual determination and protect against reprogramming of cells from one sex to the other.

Previous research at the University of Minnesota's Department of Genetics, Cell Biology, and Development showed sex determination is not permanent. Using a mouse model, researchers found the sex of gonadal cells those found in the ovaries or testes require maintenance throughout life. This research also showed loss of a single transcription factor can result in the transformation of male cells into female cells.

"DMRT1 in the testis and FOXL2 in the ovary have been identified as key transcription factors responsible for maintaining sexual differentiation. What we asked in this study was how the cells maintain sexual differentiation and why their sex determination requires continuous protection," said David Zarkower, Ph.D., principal author and director of the Developmental Biology Center at the University of Minnesota.

Zarkower's research team took a closer look at DMRT1 and determined it partners with the male fetal sex determination gene called Sox9 to maintain male sexual determination after birth in a mouse model. Part of that work includes silencing genes normally involved in the female fetal sex determination process. This discovery indicates lifelong sex determination maintenance requires a process related to prenatal sex determination.

Another notable discovery is DMRT1's ability to limit retinoic acid (RA) signaling, preventing RA from activating genes normally involved in female sex determination and female organ development.

"While RA signaling between cells is absolutely required for sperm production and male fertility, we found that RA also has a dark side. If DMRT1 is not there to act as a guardian of maleness, RA has the potential to activate genes driving male-to-female transdifferentiation," said Zarkower. "This shows cell signaling can transform the identities of the very cells that use it from male to female. We think other cell types may also require similar mechanisms allowing them to use critical signaling molecules without becoming reprogrammed."


'/>"/>
Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Related biology news :

1. Sexual conflict affects females more than males, says new research on beetles
2. Male or female?
3. In sex-reversed cave insects, females have the penises
4. Hormone in crab eyes makes it possible for females to mate and care for their young
5. White silk wrappings key to female spiders heart
6. Does it pay to be a lover or a fighter? It depends on how you woo females
7. Boost careers of female scientists: Make sure women help choose meeting speakers
8. Mating is the kiss of death for certain female worms
9. Multiple mates worth the risk for female prairie dogs
10. Different gene expression in male and female brains may help explain sex differences in brain disorder
11. Older siblings cells can be passed from female dogs to their puppies in the womb, MU researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)... 2016  Syngrafii Inc. and San Antonio Credit ... includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution ... will result in greater convenience for SACU members ... maintaining existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/2/2016)... The Weather Company , an IBM Business (NYSE: IBM ... which consumers will be able to interact with IBM Watson ... or text and receive relevant information about the product or ... long sought an advertising solution that can create a one-to-one ... valuable; and can scale across millions of interactions and touchpoints. ...
(Date:5/24/2016)... IRVINE, Calif. , May 24, 2016 Ampronix facilitates superior patient care ... LMD3251MT  3D medical LCD display is the latest premium product recently added to ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche ... with peritoneal or pleural mesothelioma. Their findings are the subject of a new article ... Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients ...
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, into ... for over 35 years, is proud to add Target to its list of ...
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
Breaking Biology Technology: