Navigation Links
Malaria medication may help against 1 type of frontotemporal dementia
Date:2/2/2011

sed the test were three drugs that are already on the market to treat various diseases: a medication for angina pectoris (bepridil), one for heart rhythm problems (amiodarone) and the widely used malaria drug chloroquine. Chloroquine increased the progranulin level not only in experiments with mouse cells to normal, but also in cells from patients with the defective progranulin gene.

In a clinical study in collaboration with the University of London, the team of Prof. Haass and Dr. Capell will now investigate whether chloroquine actually helps against progranulin dependent frontotemporal dementia. The human studies can be started very soon, as chloroquine has been used on countless patients, so that serious side effects are not to be expected. Even though the Munich scientists are optimistic, Prof. Haass warns against exaggerated hopes. "Experience shows that the step from cell and animal models to the patient is always connected with considerable difficulties. It will take several years until we know, whether chloroquine can be used as therapy for progranulin dependent frontotemporal dementia," says Haass.


'/>"/>

Contact: Katrin Weigmann
katrin.weigmann@dzne.de
49-228-433-02263
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Malaria modeling and control focus of workshop
2. Malaria-infected cells stiffen, block blood flow
3. New study examines immunity in emerging species of a major mosquito carrer of malaria
4. Researchers link cerebral malaria to epilepsy, behavior disorders
5. UC Riverside cell biologist to investigate how malaria parasite multiplies in red blood cells
6. International malaria research consortium tackles deadly disease
7. Genetic markers offer new clues about how malaria mosquitoes evade eradication
8. Malaria research begins to bite
9. Malarias newest pathway into human cells identified
10. Novartis and collaborators discover novel antimalarial drug candidate
11. New methods, new math speed detection of drug-resistant malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... Nature Climate Change , suggests that if current ... exceed, the global targets for total greenhouse gas (GHG) emissions ... all think carefully about the food we choose and its ... is just one of a number of actions that need ... there is enough food for all. , As populations ...
(Date:8/29/2014)... have made some surprising discoveries about the body,s ... virus (SIV), the team found that specialized cells ... responders to viral invasion and are the source ... interleukin-1 beta (IL-1β). , Though aimed at ... the gut epithelium that provides a barrier to ...
(Date:8/29/2014)... from the University of Texas Medical Branch at Galveston has ... antibodies can completely protect monkeys against a lethal dose of ... time when the disease is severe. , Thomas Geisbert, professor ... Nature discussing advances in Ebola treatment research. The filoviruses ... most deadly of pathogens, with fatality rates of up to ...
Breaking Biology News(10 mins):Changing global diets is vital to reducing climate change 2Changing global diets is vital to reducing climate change 3Changing global diets is vital to reducing climate change 4The early cost of HIV 2Leading Ebola researcher at UTMB says there's an effective treatment for Ebola 2
... North Carolina State University indicates that even a sharp increase ... 2050 would not significantly reduce emissions of high-profile air pollutants ... a catch-all term that includes hybrid, plug-in hybrid and battery ... may be over the next 40 years in terms of ...
... To understand how feeding interactions are structured, researchers from ... simplest food webs on Earth: the moths and butterflies of ... and flies developing on their prey (called host), killing it ... system was mind-boggling", explains Helena Wirta, the lead author of ...
... pathogen that typically infects plants has been found in ... working in the U.S. and Beijing, China report their ... of the American Society for Microbiology. The routine ... in the serendipitous detection of Tobacco Ringspot Virus, or ...
Cached Biology News:Study: Electric drive vehicles have little impact on US pollutant emissions 2DNA barcodes change our view on how nature is structured 2DNA barcodes change our view on how nature is structured 3Pathogenic plant virus jumps to honeybees 2
(Date:8/29/2014)... 29, 2014 Local veterinarian, Dr. Keith ... are seeking candidates to participate in an investigational study ... The ultimate goal of this study is to determine ... one or two arthritically affected joints can help reduce ... Candidates for the current investigational study must be older ...
(Date:8/29/2014)... August 29, 2014 A major challenge ... biotech start-up dense realm of Boston-Cambridge, is gaining visibility ... investors. James Sherley, the Director of Boston’s Adult Stem ... local and national visibility of his company an important ... , In addition to a social media marketing ...
(Date:8/28/2014)... 28, 2014 Best Sanitizers, Inc., a ... food processing industry, is asking industry professionals to prepare ... of the E2 soap they’re currently using to the ... . Hand hygiene is critical to fighting cross-contamination ... environment. Six key criteria are identified to evaluate the ...
(Date:8/28/2014)... research platform uses a laser to measure ... stress and heating, an approach likely to ... and batteries., This new technique, called nanomechanical ... and the surface stress of microscale structures ... the merits of surface-stress influence on mechanical ...
Breaking Biology Technology:Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3
... sensor networks and mobile devices shrink toward the microscale, ... suitable power sources. Because even the tiniest battery is ... are exploring nanosize systems that can salvage energy from ... have shown that a single nanowire can produce power ...
... Lexicon,Pharmaceuticals, Inc. (Nasdaq: LXRX ) today ... president and chief scientific,officer, will present at the ... Partners LLC,s ThinkClinic at The Pierre in New,York, ... 12:30 p.m. Eastern Time. A live webcast ...
... MANHATTAN, Kan., Sept. 27 Cattle producers,soon will find ... and the,food supply safe are as close at hand ... Kansas State University is leading to the creation of,software ... Sanderson,associate professor of production medicine at K-State,s College of,Veterinary ...
Cached Biology Technology:Nanowire generates power by harvesting energy from the environment 2Lexicon Pharmaceuticals to Present at ThinkEquity ThinkClinic 2K-State Research Leading to Software to Help Nation's Cattle Producers Identify Biosecurity Risks, Evaluate Impact of Cow-Calf Diseases Online 2