Navigation Links
Malaria medication may help against 1 type of frontotemporal dementia
Date:2/2/2011

Frontotemporal dementia is caused by a breakdown of nerve cells in the frontal and temporal region of the brain (fronto-temporal lobe), which leads to, among other symptoms, a change in personality and behavior. The cause of some forms of frontotemporal dementia is a genetically determined reduction of a hormone-like growth factor, progranulin. Scientists around Dr. Anja Capell and Prof. Christian Haass have now shown that various drugs that are already on the market to treat malaria, angina pectoris or heart rhythm disturbances can increase the production of progranulin. Accordingly, these drugs are good candidates for treatment of this specific form of frontotemporal dementia. The work will be published in the online edition of the scientific journal Journal of Neuroscience on February 2nd, 2011.

Progranulin is needed in the human brain as a protective factor for sensitive nerve cells, too little progranulin therefore results in a progressive neuronal cell death. As for almost every other gene, there are also two copies of the progranulin gene in the cell. In patients with progranulin dependent frontotemporal dementia, one of the two copies is defective, leading to a 50% reduction in progranulin levels. To rescue the lack of progranulin, the Munich researchers tested various substances for their ability to stimulate the remaining progranulin production and identified a drug called bafilomycin (BafA1). They then examined the molecular mechanism underlying the impact of BafA1 on progranulin more closely. Growth factors such as progranulin are produced in cellular membrane inclusions, known as vesicles. BafA1 has an alkalizing effect on these vesicles: After administration of BafA1 the interior of the vesicles is less acidic and this increases the production of progranulin.

This observation encouraged the researchers to investigate further alkalizing substances for their ability to raise progranulin levels. Among the substances that pas
'/>"/>

Contact: Katrin Weigmann
katrin.weigmann@dzne.de
49-228-433-02263
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Malaria modeling and control focus of workshop
2. Malaria-infected cells stiffen, block blood flow
3. New study examines immunity in emerging species of a major mosquito carrer of malaria
4. Researchers link cerebral malaria to epilepsy, behavior disorders
5. UC Riverside cell biologist to investigate how malaria parasite multiplies in red blood cells
6. International malaria research consortium tackles deadly disease
7. Genetic markers offer new clues about how malaria mosquitoes evade eradication
8. Malaria research begins to bite
9. Malarias newest pathway into human cells identified
10. Novartis and collaborators discover novel antimalarial drug candidate
11. New methods, new math speed detection of drug-resistant malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) has announced ... Overview" report to their offering. , ... an individual is who she/he is claiming to be, and ... person,s unique physical characteristics, such as fingerprint, hand or palm ...
(Date:1/22/2015)... 13, 2015 Technology Showcase, Hall E -   EyeLock ... today announced it will showcase its EyeLock ID technology integrated ... Department of Energy,s Oak Ridge National Laboratory (ORNL) ... EyeLock,s iris identity authentication technology is being used to validate ...
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... technology and tech stocks, releases video from the CES 2015 ... security consultant Apollo Robbins . Apollo shows ... Wocket™ biometric smart wallet, a product of NXT-ID, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3
... of biological processes; it is an active participant. Protein folding ... the solvent play a key role. So far, the emphasis ... of the protein backbone and its side chains. Researchers led ... to detect changes in the proteinwater network during protein folding ...
... food according to how stocked their nests are, say ... bumblebees return to the nest from a successful foraging ... mates to also go out and find food. Scientists ... response from all bees. But new research from Queen ...
... The prospect of climate change sparking food and water ... previously thought, with new research by an Australian climate ... key parts of the region., Recent projections from the ... storm activity in the eastern Mediterranean would decline this ...
Cached Biology News:Keeping an eye on the surroundings 2Smells like bees' spirit 2Climate change may boost Middle East rainfall 2
(Date:3/3/2015)... , Mar. 03, 2015 Research and ... the addition of Jain PharmaBiotech,s new report ... to their offering. , Gene ... vectors, nonviral vectors and cell therapy with genetically ... of drug delivery and various routes of administration ...
(Date:3/3/2015)... Elsevier,s DirectCourse online curricula ... training to comply with new CMS requirements   ... new crosswalk tool to help providers of ... direct service workers as a means to comply with ... CMS amended the regulations, effective March 17, ...
(Date:3/3/2015)... Md. , March 3, 2015  Synthetic Biologics, Inc. ... infections and diseases, with a focus on protecting the microbiome, ... is scheduled to present at the 27th Annual ROTH Conference ... Laguna Niguel in Dana Point, ... Tuesday, March 10, 2015 at 1:00 p.m. (Pacific Time). ...
(Date:3/3/2015)... VILLAGE, Nev. , March 3, 2015  PDL ... PDLI ) today announced that the third of three ... voluntarily dismissed without prejudice. On February 2, ... Company last September on behalf of a putative class ... Biopharma, Inc., et al., No. 2:14-CV-01526-APG-NJK (D. Nev.), was ...
Breaking Biology Technology:Gene Therapy Market Report 2014-2024 - Technologies, Markets and Companies 2Gene Therapy Market Report 2014-2024 - Technologies, Markets and Companies 3Elsevier's DirectCourse Can Help States Meet and Exceed New CMS Requirements for Home and Community-Based Services 2Elsevier's DirectCourse Can Help States Meet and Exceed New CMS Requirements for Home and Community-Based Services 3Synthetic Biologics to Present at the 27th Annual ROTH Conference 2PDL BioPharma Announces Dismissal of Third and Final Shareholder Lawsuit 2
... Small Interfering RNAs (siRNAs) are , ... mRNAs for degradation via a cellular process termed RNA interference , ... described , the use of vectors ... knockdown studies (for a review, see Tuschl, 2002). Two different , ...
... The RNaseAlert QC System, when used in conjunction , ... rapid and , ultra-sensitive assay for ... RNaseAlert QC System also detects a variety of other nucleases, , ... mung bean nuclease, and Benzonase. In ...
... , ... sample lysis with MagMAX magnetic bead-based RNA isolation , ... Procedure is compatible with fresh, , ... Streamlined procedure allows high , ...
Cached Biology Technology:More siRNA Vectors for RNA Interference 2More siRNA Vectors for RNA Interference 3More siRNA Vectors for RNA Interference 4More siRNA Vectors for RNA Interference 5More siRNA Vectors for RNA Interference 6More siRNA Vectors for RNA Interference 7Measuring RNase Activity A Real-time Kinetic Analysis 2Measuring RNase Activity A Real-time Kinetic Analysis 3Measuring RNase Activity A Real-time Kinetic Analysis 4Measuring RNase Activity A Real-time Kinetic Analysis 5High Throughput RNA Isolation for High Performance Microarray Analysis 2High Throughput RNA Isolation for High Performance Microarray Analysis 3High Throughput RNA Isolation for High Performance Microarray Analysis 4
Mouse IL-31 RA Biotinylated Affinity Purified PAb...
Sf21 cells derived from Spodoptera frugiperda ovarian cells are recommended for high-level production of recombinant proteins. Higher expression levels of some proteins are seen due to the larger ce...
... consists of universal lysis buffer, PCR mix, ... 100 25 l volume PCR reactions. This ... negative or positive rod and coccus bacteria, ... Cereus, Staphylococcus Aureus, Streptococcus Agalactiae, and etc. ...
...
Biology Products: