Navigation Links
Malaria-infected cells stiffen, block blood flow
Date:12/20/2010

PROVIDENCE, R.I. [Brown University] Although the incidence of malaria has declined in all but a few countries worldwide, according to a World Health Organization report earlier this month, malaria remains a global threat. Nearly 800,000 people succumbed to the mosquito-borne disease in 2009, nearly all of them in the developing world.

Physicians do not have reliable treatment for the virus at various stages, largely because no one has been able to document the malaria parasite's journeys in the body.

Now researchers at Brown University and the Massachusetts Institute of Technology have used advanced computer modeling and laboratory experiments to show how malaria parasites change red blood cells and how the infected cells impede blood flow to the brain and other critical organs.

Their findings, published in the early online edition of the Proceedings of the National Academy of Sciences, could help doctors chart, in real time, the buildup in the body of cells infected with malaria or other diseases (such as sickle-cell anemia) and to prescribe treatment accordingly.

"The idea is to predict the evolution of these diseases, just like we predict the weather," said George Karniadakis, professor of applied mathematics at Brown and corresponding author on the paper.

The researchers worked with Plasmodium falciparum, a parasite that can cause cerebral malaria by lodging in capillaries of the brain, especially among children. The parasite is found globally but is most common in Africa.

Once introduced into the human body by an infected mosquito's bite, the parasite invades red blood cells. Healthy red blood cells are tremendously elastic; even though they can reach 8 microns in length and 2 microns in thickness, they can easily slide through a capillary just 3 microns in diameter. Capillaries are vital conduits in the human brain and other organs; red blood cells are key transporters of oxygen and nutrien
'/>"/>

Contact: Richard Lewis
Richard_Lewis@brown.edu
401-863-3766
Brown University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Blocking the critical structure that lets cancer cells move -- their feet
2. A protein called cFLIP makes tumor cells in breast cancer resistant to treatments
3. Stem cells turned into complex, functioning intestinal tissue in lab
4. Directed self-assembly of vertical nanotubes for biosensors, logic, nano-biofuel cells
5. On...off...on...off... The circuitry of insulin-releasing cells
6. Shotgun method allows scientists to dissect cells sugar coatings
7. Plant clock gene also works in human cells
8. Scripps Research scientists redefine the role of plasma cells in the immune system
9. Finger-trap tension stabilizes cells chromosome-separating machinery
10. Remarkable biological complexity of bacterial cells is focus of newly released book
11. New imaging technique accurately finds cancer cells, fast
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Malaria-infected cells stiffen, block blood flow
(Date:7/23/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/rzzp3v/global_outlook_of ) has ... of the Biometrics Industry 2015 " report ... biometrics market is likely to witness significant growth ... the uptake of multiple technologies available. The year ... growth of biometrics in existing applications as well ...
(Date:7/21/2015)... , July 21, 2015 Passwords ... as seen in the recent U.S. Office of ... solution to the infosec conundrum, but developers and ... stored. To address this dilemma, Biometrics-as-a-Service provider HYPR ... Biometric Tokenization SDK for third party integration. ...
(Date:7/13/2015)... Conn. , Jul. 13, 2015 NXT-ID, ... "Company"), a biometric authentication company focused on the ... has filed provisional patent 62/188684 for ... achieves another new convenient and secure method to ... new, innovative payment methods, introduced with its groundbreaking ...
Breaking Biology News(10 mins):Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4
... seismic images yet of the Chicxulub crater, a mostly submerged ... a theory explaining the extinction of 70 percent of life ... was formed when an asteroid struck on the coast of ... major role in the KT Extinction Event that caused the ...
... lustrous pigments to make their buildings dazzle in the daylight, ... tiny shards of paint from the Mayan city of Copan, ... evidence of mica that would have made the buildings glitter ... mica was applied over the red paint of stucco masks ...
... Award-Winning Fingerprint Recognition Solution for HIPAA ... ... Operational Efficiencies, ATLANTA, Jan. 22 M2SYS Technology, ... has enhanced its OnRecord(TM) healthcare solution for emergency,departments and ...
Cached Biology News:Seismic images show dinosaur-killing meteor made bigger splash 2QUT researcher discovers Maya mask splendor 2LOGICARE Selects M2SYS Biometric Fingerprint Software to Ensure Patient Privacy and Protect Confidential Information 2
(Date:7/29/2015)... , July 29, 2015  AsureQuality and Ubiquitome ... testing for applications in food and primary production ... powered real-time PCR device, the Freedom4. ... through to the supermarket shelf for producers, processors ... involvement in animal disease control and pest management ...
(Date:7/29/2015)... DUBLIN , July 29, 2015 ... ) has announced the addition of the ... to their offering. The Global Biosimilars ... study of the rapidly growing biosimilars market. With ... industry striving to minimize costs, biosimilars are being ...
(Date:7/29/2015)... CHICAGO , July 29, 2015  AmnioChor Inc., ... cell technology, is very pleased to announce that the ... has agreed to invest in their seed round ... OmniBank placental tissue storage capabilities. AmnioChor,s ... placenta, and the human stem cells living within those ...
(Date:7/29/2015)... SAN DIEGO , July 29, 2015  Pfenex ... quarter 2015 financial results will be released on Thursday, ... 8:30 am Eastern Time, Pfenex management will host a ... a business update.  A press release outlining the financial ... to the call. Please call 1-866-376-8058 (US) ...
Breaking Biology Technology:AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3The Musculoskeletal Transplant Foundation Agrees to Invest in AmnioChor 2Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2
... , LUMBY, BC, Oct. 2 /PRNewswire-FirstCall/ - avVaa World ... biotechnology company, manufacturer and distributor of nationally branded therapeutic, ... that will feature their Neuroskin(R) Psoriasis Relief DRTV commercial ... Health Care Products Inc. is launching a two week ...
... ... pharmaceuticalstability.com , ... Mountain, NC (PRWEB) October 2, 2009 -- Parameter Generation and Control, Inc (PGC) and ... new catalog and web site called "Pharmaceutical Stability Solutions". This brochure and website ...
... PHILADELPHIA and LONDON, Oct. 1 Thomson Reuters announced ... and challenges facing foreign companies interested in entering the ... titled "The Japanese generic drug market: opportunities and strategies ... expirations prior to 2012, a rapidly aging population and ...
Cached Biology Technology:avVaa World Health Care Products Inc. Announces DRTV Test Television Stations 2avVaa World Health Care Products Inc. Announces DRTV Test Television Stations 3Parameter Generation and Control Launches New Catalog "Pharmaceutical Stability Solutions" 2Thomson Reuters Explores the Opportunities and Challenges of Entering the Japanese Generic Drug Market 2Thomson Reuters Explores the Opportunities and Challenges of Entering the Japanese Generic Drug Market 3
... GELase™ Agarose Gel-Digesting Preparation contains a unique ... simple, quantitative recovery of intact DNA and ... gels following electrophoresis in TAE, TBE, MOPS, ... digested directly in the TAE, TBE, MOPS, ...
... Perhaps sheer in-house demand is causing shortages ... precious antibody. This can cause unwanted distractions, problems ... royalties for your hard work and endeavour! Bring ... up and market it internationally. We work under ...
... shortages in your laboratory or fellow researchers want ... problems and delays. • ... Bring us your idea and let us build ... under ISO 9001 quality assurance in design, development, ...
Topoisomerase I...
Biology Products: