Navigation Links
Malaria-infected cells stiffen, block blood flow
Date:12/20/2010

PROVIDENCE, R.I. [Brown University] Although the incidence of malaria has declined in all but a few countries worldwide, according to a World Health Organization report earlier this month, malaria remains a global threat. Nearly 800,000 people succumbed to the mosquito-borne disease in 2009, nearly all of them in the developing world.

Physicians do not have reliable treatment for the virus at various stages, largely because no one has been able to document the malaria parasite's journeys in the body.

Now researchers at Brown University and the Massachusetts Institute of Technology have used advanced computer modeling and laboratory experiments to show how malaria parasites change red blood cells and how the infected cells impede blood flow to the brain and other critical organs.

Their findings, published in the early online edition of the Proceedings of the National Academy of Sciences, could help doctors chart, in real time, the buildup in the body of cells infected with malaria or other diseases (such as sickle-cell anemia) and to prescribe treatment accordingly.

"The idea is to predict the evolution of these diseases, just like we predict the weather," said George Karniadakis, professor of applied mathematics at Brown and corresponding author on the paper.

The researchers worked with Plasmodium falciparum, a parasite that can cause cerebral malaria by lodging in capillaries of the brain, especially among children. The parasite is found globally but is most common in Africa.

Once introduced into the human body by an infected mosquito's bite, the parasite invades red blood cells. Healthy red blood cells are tremendously elastic; even though they can reach 8 microns in length and 2 microns in thickness, they can easily slide through a capillary just 3 microns in diameter. Capillaries are vital conduits in the human brain and other organs; red blood cells are key transporters of oxygen and nutrien
'/>"/>

Contact: Richard Lewis
Richard_Lewis@brown.edu
401-863-3766
Brown University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Blocking the critical structure that lets cancer cells move -- their feet
2. A protein called cFLIP makes tumor cells in breast cancer resistant to treatments
3. Stem cells turned into complex, functioning intestinal tissue in lab
4. Directed self-assembly of vertical nanotubes for biosensors, logic, nano-biofuel cells
5. On...off...on...off... The circuitry of insulin-releasing cells
6. Shotgun method allows scientists to dissect cells sugar coatings
7. Plant clock gene also works in human cells
8. Scripps Research scientists redefine the role of plasma cells in the immune system
9. Finger-trap tension stabilizes cells chromosome-separating machinery
10. Remarkable biological complexity of bacterial cells is focus of newly released book
11. New imaging technique accurately finds cancer cells, fast
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Malaria-infected cells stiffen, block blood flow
(Date:8/21/2014)... published in the journal Carcinogenesis by researchers ... for the protein adenomatous polyposis coli (APC) in suppressing ... in the U.S. , Lead author Kristi Neufeld, associate ... of the Cancer Biology program at the KU Cancer ... trying to understand the various activities of APC, a ...
(Date:8/21/2014)... in severe abdominal pain, vomiting and systemic inflammation. Every ... with the disease resulting in 1000 deaths. There is ... fluid and nutritional support. , Dr Jason Bruce, ... research, said "The major causes of pancreatitis include bile ... combined with a high fat diet. In fact, the ...
(Date:8/20/2014)... 2014 /CNW/ -  Issue Serious allergic ... become life threatening for some children.    What ... Canadians have food allergies and this number may be increasing, ... are estimated to have food allergies.  The ... and hives to breathing difficulties and loss of consciousness. Symptoms ...
Breaking Biology News(10 mins):Research offers insight into cellular biology of colorectal cancer 2Research offers insight into cellular biology of colorectal cancer 3Insulin offers new hope for the treatment of acute pancreatitis 2Information Update - Allergens and food safety at school - What's in your child's lunch? 2Information Update - Allergens and food safety at school - What's in your child's lunch? 3
... in six will get prostate cancer during his lifetime, making ... a new partnership with Areva Med, UC researchers will investigate ... of prostate cancer tumors. In the study, UC researchers ... efficacy of a new agent targeted against a specific protein ...
... researchers from the Johns Hopkins University School of Medicine ... by European scientific institutions. Andrew P. Feinberg, M.D., ... of the Center for Epigenetics, will receive the honorary ... ceremony in the Stockholm City Hall on May 7. ...
... Researchers in China are reporting that they have found a ... cells -- that have been reprogrammed into a primordial, embryonic-like ... a paper published online last week by the Journal ... the Chinese Academy of Sciences point to a marker they ...
Cached Biology News:UC to test targeted treatment for prostate cancer 22 Hopkins scientists awarded European honorary doctorates 2Chinese scientists discover marker indicating the developmental potential of stem cells 2
(Date:8/20/2014)... , Aug. 20, 2014 Clintrax ... services located in Raleigh, NC ... Evans as Vice President of Administration. ... will oversee all corporate processes, including their alignment ... Clintrax Global, Brad worked as an HR executive, ...
(Date:8/20/2014)... Livermore, California (PRWEB) August 20, 2014 ... to develop and apply the most complete climate ... challenging and demanding climate change issues. , Eight ... combining forces with the National Center for Atmospheric ... in the new effort. Other participating national laboratories ...
(Date:8/20/2014)... Calif. , Aug. 20, 2014 /PRNewswire-iReach/ -- ... the transformative collaboration between the school,s bioengineering department ... part of the Intel® Software Academic Program, UCSD,s ... sciences and the human body.  ... The study exhibits the work of Dr. ...
(Date:8/19/2014)... August 19, 2014 Shimadzu Scientific ... systems, Prominence-i and Nexera-i, adding to the company’s ... excellent functionality, an intuitive operating environment, and full ... more efficient workflow for conventional to ultra-high-speed analysis. ... intuitive and intelligent design so users can begin ...
Breaking Biology Technology:Clintrax Global, Inc. Announces Addition to Executive Team 2New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3
... Roche (SWX: ROG.VX; RO.S; OTCQX; RHHBY) today announced that ... accepted for payment all shares validly tendered and not ... shares of common stock of Memory Pharmaceuticals Corp. (Nasdaq: ... cash.As of the expiration of the tender offer, a ...
... Inc.,(Nasdaq: BNVI ) announced today results ... to identify estrogenic drugs that are,safer. The data, ... new regulatory elements can distinguish the estrogenic,pharmacological activity ... prediction of specific tissue effect. , ...
... CHICAGO, Dec. 31 A landmark study published today ... that use of a specially-designed machine to store kidneys ... function when compared to those stored in a traditional ... the LifePort(R) Kidney Transporter monitors the temperature and vascular ...
Cached Biology Technology:Roche Purchases Shares in Tender Offer For Memory Pharmaceuticals Corp. 2Roche Purchases Shares in Tender Offer For Memory Pharmaceuticals Corp. 3Roche Purchases Shares in Tender Offer For Memory Pharmaceuticals Corp. 4Bionovo Publishes Discoveries in Predictable Tissue Selectivity for Selective Estrogen Receptor Modulators Platform 2Bionovo Publishes Discoveries in Predictable Tissue Selectivity for Selective Estrogen Receptor Modulators Platform 3Study Shows Machine Perfusion Significantly Improves Transplant Results 2Study Shows Machine Perfusion Significantly Improves Transplant Results 3
... Taq DNA Polymerase is a thermostable recombinant ... in primer extension and other molecular biology ... which provides easy and quick identification of ... allows confirmation of complete mixing. The inert ...
... The EnzChek Lysozyme Assay Kit (E-22013) ... measure levels of lysozyme,activity in solution. ... down to 20 U/mL (Figure 1). ... lysodeikticus cell,walls, which are labeled to ...
RNA oligomers from 10 to 50 bases purified by PAGE and MS-checked. RNAs are supplied dried and fully deprotected....
... (Cap Analog) is used for the synthesis ... vitro transcription reactions. Substitution of cap analog ... in an in vitro transcription reaction results ... into a large fraction of the transcripts. ...
Biology Products: