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Malaria immunity trigger found for multiple mosquito species
Date:3/13/2009

ctivated this immune response in advance of infection, giving the mosquito a head start in defeating the invading parasite."

Dimopoulos and his colleagues Lindsey Graver and Yuemei Dong also found that Rel 2 activation did not affect the survival and egg laying fitness of the modified mosquitoes.

"This came as a pleasant surprise since it essentially means that we one day could spread this trait in natural mosquito populations using genetic modification. Furthermore, by activating Rel 2, the genetically modified mosquitoes will attack the malaria parasite with several independent immune factors, and this will make it very difficult for Plasmodium to develop resistance," said Dimopoulos.


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Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health
Source:Eurekalert

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