Navigation Links
Malaria drug combo could help prevent pregnancy complications in lupus patients
Date:1/22/2014

An anti-malaria drug combination might be useful in helping to prevent pregnancy complications in women with lupus and the related disorder antiphospholipid syndrome, Yale School of Medicine researchers have found in a new study published in the American Journal of Reproductive Immunology.

Circulating antibodies called antiphospholipid antibodies are normally produced by the body to recognize and attack bacteria and other microbe. In those with lupus and/or antiphospholipid syndrome, however, these antibodies recognize and attack the body's own proteins, putting women at high risk for recurrent pregnancy loss and late gestational complications, such as preeclampsia.

Patients with lupus or antiphospholipid syndrome are often treated with the anti-malarial drug hydroxychloroquine. While the drug can be safely continued during pregnancy, it was unknown whether it might be beneficial in preventing pregnancy complications in women with lupus and/or antiphospholipid syndrome.

In this new study, senior author Vikki M. Abrahams, associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale, and first author and Yale medical student Caroline Albert explored whether the drug could treat obstetrical antiphospholipid syndrome.

Abrahams and Albert used a lab-based system to measure the detrimental effects of antiphospholipid antibodies on human placental trophoblast cell function.

"We found that hydroxychloroquine partially reversed some, but not all, of the detrimental effects of antiphospholipid antibodies on human placental cell function," said Abrahams. "So perhaps some form of combination therapy that includes hydroxychloroquine may be beneficial to pregnant patients with lupus and/or antiphospholipid syndrome."


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Page: 1

Related biology news :

1. Notre Dame researchers using novel method to combat malaria drug resistance
2. Scientists find Achilles heel in life-threatening malaria parasites
3. Drug could reverse scourge of cerebral malaria for survivors
4. Game on! UCLA researchers use online crowd-sourcing to diagnose malaria
5. African scientist, designer partner to fashion anti-malaria garment that wards off bugs
6. Considerable prevalence of both malaria, STIs exist among pregnant women in sub-Saharan Africa
7. New discoveries about severe malaria
8. New book tells story of 10-year-old malaria project
9. MMV develops framework to assess risk of resistance for antimalarial compounds
10. African research identifies strong candidate for possible single-dose malaria cure
11. WSU/USDA scientist creates test, treatment for malaria-like sickness in horses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition ... Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the ... a CAGR of 29.63% between 2017 and 2022. ... ... ...
(Date:3/22/2017)... NEW YORK , March 21, 2017 /PRNewswire/ ... Customer Marketing Cloud used by retailers such as ... in its platform — Product Recommendations and Replenishment. Using ... to give more personalized product and replenishment recommendations ... purchases, but also on predictions of customer intent ...
(Date:3/20/2017)... 2017 PMD Healthcare announces the release of ... Management System (WMS), a remote, real-time lung health monitoring ... Healthcare is a Medical Device, Digital Health, and Chronic ... creating innovative solutions that empower people to improve their ... PMD developed the first ever personal spirometer, Spiro PD, ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... for model aircraft flying hobbyists, and the University Aviation Association (UAA), the unifying ... students. The UAS4STEM Collegiate Challenge will encourage teamwork, competition, and success through a ...
(Date:6/22/2017)... ... 21, 2017 , ... Building on the success of the inaugural RAADfest last ... very latest developments in radical life extension. RAADfest combines cutting edge science presented for ... of personal development, making it the largest most comprehensive and inclusive super longevity event ...
(Date:6/22/2017)... ... June 22, 2017 , ... For ... has produced a Spotlight series on “Cell Therapy Regulation” for ... by leading experts on the unique regulatory challenges of stem cell medical research. ...
(Date:6/22/2017)... (PRWEB) , ... June 22, 2017 , ... ... provider, announced the release of Limfinity® version 6.5, a content-packed update to the ... continue to gain a larger and more diverse base of customers among labs ...
Breaking Biology Technology: