Navigation Links
Malaria drug combo could help prevent pregnancy complications in lupus patients
Date:1/22/2014

An anti-malaria drug combination might be useful in helping to prevent pregnancy complications in women with lupus and the related disorder antiphospholipid syndrome, Yale School of Medicine researchers have found in a new study published in the American Journal of Reproductive Immunology.

Circulating antibodies called antiphospholipid antibodies are normally produced by the body to recognize and attack bacteria and other microbe. In those with lupus and/or antiphospholipid syndrome, however, these antibodies recognize and attack the body's own proteins, putting women at high risk for recurrent pregnancy loss and late gestational complications, such as preeclampsia.

Patients with lupus or antiphospholipid syndrome are often treated with the anti-malarial drug hydroxychloroquine. While the drug can be safely continued during pregnancy, it was unknown whether it might be beneficial in preventing pregnancy complications in women with lupus and/or antiphospholipid syndrome.

In this new study, senior author Vikki M. Abrahams, associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale, and first author and Yale medical student Caroline Albert explored whether the drug could treat obstetrical antiphospholipid syndrome.

Abrahams and Albert used a lab-based system to measure the detrimental effects of antiphospholipid antibodies on human placental trophoblast cell function.

"We found that hydroxychloroquine partially reversed some, but not all, of the detrimental effects of antiphospholipid antibodies on human placental cell function," said Abrahams. "So perhaps some form of combination therapy that includes hydroxychloroquine may be beneficial to pregnant patients with lupus and/or antiphospholipid syndrome."


'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Page: 1

Related biology news :

1. Notre Dame researchers using novel method to combat malaria drug resistance
2. Scientists find Achilles heel in life-threatening malaria parasites
3. Drug could reverse scourge of cerebral malaria for survivors
4. Game on! UCLA researchers use online crowd-sourcing to diagnose malaria
5. African scientist, designer partner to fashion anti-malaria garment that wards off bugs
6. Considerable prevalence of both malaria, STIs exist among pregnant women in sub-Saharan Africa
7. New discoveries about severe malaria
8. New book tells story of 10-year-old malaria project
9. MMV develops framework to assess risk of resistance for antimalarial compounds
10. African research identifies strong candidate for possible single-dose malaria cure
11. WSU/USDA scientist creates test, treatment for malaria-like sickness in horses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/13/2017)... 13, 2017 Sandata Technologies, LLC, a ... homecare industry, including Electronic Visit Verification™ (EVV™), announced ... Jugs, as Senior Vice President of Product Management. ... of homecare experience to Sandata, where he will ... to align Sandata,s suite of solutions with the ...
(Date:1/12/2017)... and PUNE, India , January 12, 2017 ... and Forecasts, 2015 - 2022," projects that the global biometric technology market is expected ... from 2016 to 2022. Continue Reading ... ... ...
(Date:1/6/2017)... , Jan. 6, 2017  Privately-held CalciMedica, ... studies in healthy volunteers of a novel calcium ... treat acute pancreatitis. Acute pancreatitis, ... a mild disorder, but can be very serious.  In ... and sepsis, where extended hospital stays, time in ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... Pa. , Jan. 24, 2017   Bracket ... provider, today announced the addition of Jennifer Peters ... Senior Vice President and General Manager for the Scientific ... responsible for Bracket,s work in Rater Training, Quality Assurance, ... Bracket with a strong skillset and demonstrated record building ...
(Date:1/24/2017)... New York, NY (PRWEB) , ... January 24, ... ... index (BMI), larger waist circumference, and increased serum leptin levels had a positive ... study. The study published in the International Neurourology Journal involved ...
(Date:1/24/2017)... ... January 23, 2017 , ... ... science through unique partnerships, seeks outstanding early career nominees for the 2017 New ... to meeting the needs of a world in which one in nine people ...
(Date:1/24/2017)... --  Instrument Business Outlook ( IBO ) ... ) the 2016 Company of the Year. ... developments in the analytical and life science instrumentation ... outstanding technical, operational and financial results throughout the ... "In 2016, Bio-Techne capitalized on opportunities in life ...
Breaking Biology Technology: