Navigation Links
Making sense of antisense microRNAs
Date:12/31/2007

Three independent papers in the January 1st issue of G&D report on the discovery of a bidirectionally transcribed microRNA (miRNA) locus in Drosophila. The studies from Drs. Alexander Stark and Manolis Kellis (MIT) and colleagues, and from Dr. Eric Lai (MSKCC) and colleagues, both reveal that antisense transcription of the Hox miRNA locus, miR-iab-4, generates the novel miRNA precursor mir-iab-8, which is processed into active regulatory RNAs. When ectopically expressed, mir-iab-8 generates homeotic phenotypes via direct repression of Hox gene targets. The paper from Dr. Welcome Bender (Harvard Medical School) demonstrates that knock out of miR-iab-4 reveals the existence of a miRNA transcribed from the opposite strand. Furthermore, the loss of the antisense miRNA causes subtle derepression of a hox gene and results in sterility of the mutant flies. The identification of additional antisense miRNAs in Drosophila and mammals suggests this as a mechanism that may contribute to the diversification of miRNA function.


'/>"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. Coal and black liquor can produce energy from papermaking
2. Another type of nanotube, a how-to guide to making bamboo-structured carbon nanotubes
3. GBIF making the search for biodiversity research resources easier
4. Advance in effort to fight malaria by tricking the mosquitos sense of smell
5. Neuronal circuits able to rewire on the fly to sharpen senses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2017)... Research and Markets has announced the addition ... and Commercial Aspects" to their offering. ... Biomarkers play an ... for selection of treatment as well for monitoring the results. ... in modern medicine. Biochip/microarray technologies and next generation sequencing are ...
(Date:2/8/2017)... NEW YORK , Feb. 7, 2017 Report ... ... and should reach $11.4 billion by 2021, growing at a ... Report Includes - An overview of the global markets for ... from 2015, estimates for 2016, and projections of compound annual ...
(Date:2/7/2017)... Feb. 7, 2017 Zimmer Biomet Holdings, Inc. ... healthcare, will present at the LEERINK Partners 6th Annual ... Hotel on Wednesday, February 15, 2017 at 10 a.m. ... the presentation can be accessed at http://wsw.com/webcast/leerink28/zbh .  ... conference via Zimmer Biomet,s Investor Relations website at ...
Breaking Biology News(10 mins):
(Date:2/16/2017)... 2017   Capricor Therapeutics, Inc. (NASDAQ: ... developing first-in-class biological therapies for cardiac and other ... to terminate its license agreement with the Mayo ... Cenderitide. "Our decision to return these ... our efforts to advance our core cell and ...
(Date:2/16/2017)... , Feb. 16, 2017  Champions Oncology, Inc. ... the development and sale of advanced technology solutions and ... drugs, today announced the addition of new cohorts of ... These new models will expand Champions, product line in ... and neck cancer, AML, and non-small cell lung cancer ...
(Date:2/16/2017)... WEST LAFAYETTE, Indiana (PRWEB) , ... ... ... a division of Albany Molecular Research Inc. has further extended its industry ... sector. This service offers state-of-the-art cGMP techniques and methods for the ...
(Date:2/15/2017)... Pharmaceuticals Inc. (Vanda) (NASDAQ: VNDA), today announced financial ... full year ended December 31, 2016. ... we continued to demonstrate strong growth in our ... said Mihael H. Polymeropoulos, M.D., Vanda,s President and ... 2017 milestones underscores Vanda,s commitment to bringing important ...
Breaking Biology Technology: