Navigation Links
Making metabolism more inefficient can reduce obesity
Date:10/3/2008

In a discovery that counters prevailing thought, a study in mice has found that inactivating a pair of key genes involved in "fat-burning" can actually increase energy expenditure and help lower diet-induced obesity. These unusual findings, appearing this week in the JBC, might lead to some new roads in weight-loss therapy.

Humans and other warm-blooded animals need to continually "burn fat" in order to maintain body temperature, and it's currently believed that an individual's fat-burning capacity, or thermogenic potential, is connected with obesity risk; that is, people with more thermogenic potential are less likely to become obese. In fact, bodybuilders and dieters looking to burn fat commonly use thermogenic supplements like ephedra.

In theory, lowering thermogenesis should increase the chances of obesity, but Leslie Kozak and colleagues at Pennington Biomedical Research Center found that this may not be the case. They knocked-out two thermogenic genes in mice, Ucp1 (mitochondrial uncoupling protein) and Gdm (glycerol 3-phosphate dehydrogenase) and then fed the mice a high-fat diet while rearing them at a cool 20 C (68 F).

Surprisingly, these mice were actually quite resistant to obesity, which resulted from the mice turning on backup heat generators, so to speak. Lacking Ucp1 and Gdm, genes that have been designed for the efficient production of heat, mouse white fat cells activated alternate, and more inefficient, fat burning pathways. In this case, though, inefficiency is beneficial, as the mice had to burn more fat than normal to stay warm (by analogy you burn more wood by warming your house with an open fire then with a well designed wood stove).

Importantly, after spending 10 weeks at 20 C the mice retained these alternate pathways even after transferring to 28 C (82 F), suggesting their bodies had adapted to the change. Thus, Kozak and colleagues note, fat burning does not necessarily require making th
'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Coal and black liquor can produce energy from papermaking
2. Another type of nanotube, a how-to guide to making bamboo-structured carbon nanotubes
3. GBIF making the search for biodiversity research resources easier
4. Making sense of antisense microRNAs
5. Is that sea otter stealing your lunch -- or making it?
6. LSU scientist finds evidence of rain-making bacteria
7. Making sure the wonder materials dont become the wonder pollutant
8. Findings a step toward making new optical materials
9. Research suggests parts of UK could be too hot for wine-making by 2080
10. Research suggests parts of UK could be too hot for wine making by 2080
11. Small protein may have big role in making more bone and less fat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... LAKE FOREST, Calif. , March 3, ... ("Company"), the leading provider of advanced cryogenic ... serving markets including immunotherapies, stem cells, cell ... health, and reproductive medicine, today announced the ... Hutchinson Cancer Research Centers, ("Fred Hutch") ...
(Date:3/2/2015)... March 2, 2015 Synaptics Inc. (NASDAQ: ... human interface solutions, today announced a new implementation ... to enable rapid and secure transactions and reliable ... gaming is a turnkey solution providing mouse and ... quickly integrate fingerprint ID solutions into their product ...
(Date:3/2/2015)... , March 2, 2015  Businesses have a ... protection company Tharon Rankins Enterprises has announced the ... an ultra-safe way for businesses to protect their ... transactions. Beconux is a biometric ... Enterprises. Functioning similarly to an ATM machine, the ...
Breaking Biology News(10 mins):Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3Personal Data Protection Company Launches New Product 2
... In the course of doing research on the mosquito-borne ... Virginia Tech researchers have discovered an inconvenient truth about ... used to detect and measure replicating viral RNA in ... using for ssqPCR is unreliable. The research appears ...
... Healthy eating, not supplements, is the best way to ... dietitian and researcher. As with vitamins, it,s best to ... taking often expensive and potentially ineffective supplements, says Gail Cresci, ... are buying stuff like crazy that is probably not even ...
... Researchers at the Michael & Susan Dell Center for ... of Public Health Austin Regional Campus found the obesity prevention ... in Texas in decreasing the prevalence of childhood obesity. ... Dell Center for Healthy Living, examined regional changes of child ...
Cached Biology News:Widely used virus assay shown unreliable when compared to other methods 2Eating right, not supplements, is best at keeping your good bacteria healthy, dietitian says 2Eating right, not supplements, is best at keeping your good bacteria healthy, dietitian says 3El Paso County serves as a model for obesity prevention, according to UT School of Public Health study 2El Paso County serves as a model for obesity prevention, according to UT School of Public Health study 3
(Date:3/3/2015)... NASA astronaut Scott Kelly , who is making final ... living and working on the International Space Station, will be ... EDT Monday, March 9. Kelly will participate from ... weeks of his training. The interviews will be preceded at ... mission training and previous spaceflights. To schedule an ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 Experts and ... schedules for one event: the Alltech REBELation exploring innovation, ... May 17-20. Now in its 31st year, Alltech’s annual ... 70 countries, and the opportunity to join the REBELation ... 7 at 11:59 p.m. EST, at which point the ...
(Date:3/3/2015)... Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced several new ... in North America , the Middle ... "Bidding activity in 2015 continues to be robust" said Derek ... for bidding in 2014, we are pleased to see the bidding ... organization,s renewed focus on select market segments where we can add ...
(Date:3/3/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/rcv4lq/gene_therapy ... Therapy Market, 2015 - 2025" report to their ... report provides an extensive study on the marketed and ... carried out in this field for over a decade ... in Asian markets; one approved in the EU). There ...
Breaking Biology Technology:NASA Astronaut Scott Kelly Available for Interviews before One-Year Space Station Mission 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 3World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 2Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 3Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 5Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 6Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 7
... York, May 26, 2012 Sanofi ... Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN ) today ... trial of SAR236553/REGN727 (Study 1003, NTC01266876) in patients ... subcutaneously administered, fully-human antibody targeting PCSK9 (proprotein convertase ...
... decades, neurologists have known that a diet high in fat ... resist drug therapy. But how the diet worked, and why, ... York Times Magazine called it "Epilepsy,s Big, Fat Miracle." ... School have proposed an answer, linking resistance to seizures to ...
... growth of crystals, do nanoparticles act as "artificial atoms" ... structures? This is the contention of a major but ... researchers at the U.S. Department of Energy (DOE),s Lawrence ... and point the way to energy devices of the ...
Cached Biology Technology:Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 2Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 3Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 4Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 5Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 6Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 7Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 8Sanofi and Regeneron Announce Publication of Positive Phase 2 Results for Lipid-Lowering PCSK9 Antibody in The Lancet 9Reverse engineering epilepsy's 'miracle' diet 2Reverse engineering epilepsy's 'miracle' diet 3Nanoparticles seen as artificial atoms 2Nanoparticles seen as artificial atoms 3
X-Gal, 1 g. 5-Bromo-4-chloro-3-indolyl-b-d-galactoside.Histochemical substrate for b-galactosidase, used in blue/white screening.Store at -20 C. Protect from moisture. Category: Nucleotides & Enzymes...
Conjugation services for Antibodies, Proteins, Oligos, Peptides, Beads, bioconjugation, antibody-oligonucleotide, LNA peptide, LNA protein, LNA antibody, HRP, Alkaline phosphatase, phycoerythrin, FIT...
FGF Receptor 1 Antibody...
Mouse Galectin-1 Affinity Purified Polyclonal Ab...
Biology Products: