Navigation Links
Making metabolism more inefficient can reduce obesity
Date:10/3/2008

In a discovery that counters prevailing thought, a study in mice has found that inactivating a pair of key genes involved in "fat-burning" can actually increase energy expenditure and help lower diet-induced obesity. These unusual findings, appearing this week in the JBC, might lead to some new roads in weight-loss therapy.

Humans and other warm-blooded animals need to continually "burn fat" in order to maintain body temperature, and it's currently believed that an individual's fat-burning capacity, or thermogenic potential, is connected with obesity risk; that is, people with more thermogenic potential are less likely to become obese. In fact, bodybuilders and dieters looking to burn fat commonly use thermogenic supplements like ephedra.

In theory, lowering thermogenesis should increase the chances of obesity, but Leslie Kozak and colleagues at Pennington Biomedical Research Center found that this may not be the case. They knocked-out two thermogenic genes in mice, Ucp1 (mitochondrial uncoupling protein) and Gdm (glycerol 3-phosphate dehydrogenase) and then fed the mice a high-fat diet while rearing them at a cool 20 C (68 F).

Surprisingly, these mice were actually quite resistant to obesity, which resulted from the mice turning on backup heat generators, so to speak. Lacking Ucp1 and Gdm, genes that have been designed for the efficient production of heat, mouse white fat cells activated alternate, and more inefficient, fat burning pathways. In this case, though, inefficiency is beneficial, as the mice had to burn more fat than normal to stay warm (by analogy you burn more wood by warming your house with an open fire then with a well designed wood stove).

Importantly, after spending 10 weeks at 20 C the mice retained these alternate pathways even after transferring to 28 C (82 F), suggesting their bodies had adapted to the change. Thus, Kozak and colleagues note, fat burning does not necessarily require making thermogenesis easier; by making it harder and forcing the body to use inefficient methods to stay warm, the same goals can be reached.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Related biology news :

1. Coal and black liquor can produce energy from papermaking
2. Another type of nanotube, a how-to guide to making bamboo-structured carbon nanotubes
3. GBIF making the search for biodiversity research resources easier
4. Making sense of antisense microRNAs
5. Is that sea otter stealing your lunch -- or making it?
6. LSU scientist finds evidence of rain-making bacteria
7. Making sure the wonder materials dont become the wonder pollutant
8. Findings a step toward making new optical materials
9. Research suggests parts of UK could be too hot for wine-making by 2080
10. Research suggests parts of UK could be too hot for wine making by 2080
11. Small protein may have big role in making more bone and less fat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2017)... , Feb. 2, 2017  EyeLock LLC, a market ... new white paper " What You Should Know About ... of ensuring user authenticity is a growing concern. In ... of users. However, traditional authentication schemes such as username/password ... Biometric authentication offers an elegant solution to the ...
(Date:1/30/2017)... Jan. 30, 2017   Invitae Corporation (NYSE: ... genetic information companies, today announced that it will report ... provide 2017 guidance on Monday, February 13, 2017, and ... day at 4:45 p.m. Eastern / 1:45 p.m. Pacific. ... will briefly review financial results, guidance, and recent developments ...
(Date:1/24/2017)... 24, 2017 Biopharm Reports has carried ... use of nuclear magnetic resonance spectroscopy (NMR). This ... profiled current practices, developments, trends and end-user plans ... growth and opportunities. These areas include growth in ... needs and innovation requirements, hyphenated NMR techniques, main ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... -- Research and Markets has announced the addition of ... Industry Forecast to 2025" report to their offering. ... The Global Bioplastics & ... 12.8% over the next decade to reach approximately $8.9 billion by ... and forecasts for all the given segments on global as well ...
(Date:2/20/2017)... YORK , Feb. 20, 2017  This Report analyzes the ... Hardware, and Biocontent. The report provides separate comprehensive analytics for the ... Europe , Asia-Pacific , ... Read the full report: http://www.reportlinker.com/p04707099-summary/view-report.html ... Annual estimates and forecasts are ...
(Date:2/20/2017)... ... February 20, 2017 , ... Cancer diagnostics and ... Oncology™” (Crosswalk), a unique precision medicine knowledge visualization and decision support platform. ... Inspirata’s diagnostic cockpit and is downloadable as an app for any mobile device ...
(Date:2/20/2017)... ... February 20, 2017 , ... ... catheters associated with peritoneal dialysis, announced today that it has published the result ... system in Peritoneal Dialysis International (PDI), the official Journal of the International ...
Breaking Biology Technology: