Navigation Links
Making memories: How 1 protein does it
Date:3/5/2012

Studying tiny bits of genetic material that control protein formation in the brain, Johns Hopkins scientists say they have new clues to how memories are made and how drugs might someday be used to stop disruptions in the process that lead to mental illness and brain wasting diseases.

In a report published in the March 2 issue of Cell, the researchers said certain microRNAsgenetic elements that control which proteins get made in cells are the key to controlling the actions of so-called brain-derived neurotrophic factor (BDNF), long linked to brain cell survival, normal learning and memory boosting.

During the learning process, cells in the brain's hippocampus release BDNF, a growth-factor protein that ramps up production of other proteins involved in establishing memories. Yet, by mechanisms that were never understood, BDNF is known to increase production of less than 4 percent of the different proteins in a brain cell.

That led Mollie Meffert, M.D., Ph.D., associate professor of biological chemistry and neuroscience at the Johns Hopkins University School of Medicine to track down how BDNF specifically determines which proteins to turn on, and to uncover the role of regulatory microRNAs.

MicroRNAs are small molecules that bind to and block messages that act as protein blueprints from being translated into proteins. Many microRNAs in a cell shut down protein production, and, conversely, the loss of certain microRNAs can cause higher production of specific proteins.

The researchers measured microRNA levels in brain cells treated with BDNF and compared them to microRNA levels in neurons not treated with BDNF. The researchers noticed that levels of certain microRNAs were lower in brain cells treated with BDNF, suggesting that BDNF controls the levels of these microRNAs and, through this control, also affects protein production. Homing in on those specific microRNAS that disappeared when cells were treated with BDNF,
'/>"/>

Contact: Vanessa McMains
vmcmain1@jhmi.edu
410-502-9410
Johns Hopkins Medical Institutions
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. The making of Dig It! the Secrets of Soil exhibit
2. Making metabolism more inefficient can reduce obesity
3. Making flies sick reveals new role for growth factors in immunity
4. Scientists present moving theory behind bacterial decision-making
5. Making the ultimate family sacrifice
6. Tips for making a green holiday from the worlds largest scientific society
7. How chromosomes meet in the dark -- Switch that turns on X chromosome matchmaking
8. Process can cut the cost of making cellulosic biofuels
9. U of Minnesota research finds most road salt is making it into the states lakes and rivers
10. MacArthur Foundation awards planning grant to improve decision-making in energy policy
11. It takes a genome: How a clash between our genes and modern life is making us sick
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Making memories: How 1 protein does it
(Date:9/1/2014)... 1, 2014, 10:20 AM EDT) It may be ... foods over unhealthy higher-calorie foods, according to new research ... Research Center on Aging (USDA HNRCA) at Tufts University ... the journal Nutrition & Diabetes , a brain ... it is possible to reverse the addictive power of ...
(Date:9/1/2014)... WASHINGTON About 50 years ago, electron microscopy revealed ... cells, move around and disappear. But scientists still don,t ... cloud-like collections of proteins are believed to be crucial ... offer a new approach to disease treatment., In the ... issuing a call to investigators from various backgrounds, from ...
(Date:9/1/2014)... and decisions of the Nomenclature Section of the XVIII ... July 2011. This meeting is held every six years ... the rules for naming algae, fungi and plants get ... naming the organisms they study. This is the primary ... for algae, fungi, and plants, which was published in ...
Breaking Biology News(10 mins):Training your brain to prefer healthy foods 2Scientists call for investigation of mysterious cloud-like collections in cells 2Week-long meeting on naming algae, fungi, and plants recorded for posterity 2
... Philip R. LeDuc and his collaborators in Massachusetts and ... that could ultimately unlock the mystery of how these ... the mechanics of biological processes in people. "What ... a protein that helps control cell behavior from a ...
... researcher based on the island of Reunion in the Indian ... Kew (RBG Kew) has used motion sensitive night cameras to ... a pollinator of flowering plants. Not only is this the ... of the Orthoptera order of insects who are better ...
... of scientists are merging methods and results from different disciplines ... of researchers in a recent issue of Evolution . ... data, however, researchers who want to analyze previous findings may ... authors say. In a commentary piece in the journal ...
Cached Biology News:Carnegie Mellon's Philip LeDuc discovers new protein function 2First known instance of a cricket as an orchid pollinator captured on film by Kew scientist 2Biologists merge methods, results from different disciplines to find new meaning in old data 2Biologists merge methods, results from different disciplines to find new meaning in old data 3
(Date:8/28/2014)... City, Ca. (PRWEB) August 28, 2014 ... E3 rating for an alcohol-based hand sanitizer, asks food ... harvest by comparing the hand sanitizer they’re currently using ... Spray . Hand hygiene is critical to fighting cross-contamination ... environment. Best Sanitizers believes there are key criteria ...
(Date:8/28/2014)... spintronics, an electronic which is not only based ... their spin and the spin-related magnetism. Spin-charge converters ... and vice versa. Recently, the research group of ... at Johannes Gutenberg University Mainz in collaboration with ... for the first time realised a new, efficient ...
(Date:8/28/2014)... , Aug. 28, 2014  Next month, executives from clinical ... key industry events beginning with Patient-Centered Clinical Trials 2014 ... Boston , September 4-5. Patient recruitment experts ... Aaron Fleishman will share insights on the benefits ... variety of tactics – from media to mobile apps – ...
(Date:8/28/2014)... 2014  Armetheon, Inc. ( www.armetheon.com ), a ... late-stage cardiovascular drug candidates, today announced that it ... of financing. The Series A round was co-led ... participation from investors that included Atheneos Capital and ... Larry Hsu , the founder of Impax Laboratories. ...
Breaking Biology Technology:Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3A new, tunable device for spintronics 2A new, tunable device for spintronics 3BBK Worldwide Leads Sessions at Key September Events 2Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3
... Company Announces 2009 Graeme Clark Scholarship WinnersDENVER, March ... advanced hearing technologies, today announced the winners of ... the Graeme Clark Cochlear Scholarship Foundation has recognized ... a Nucleus(R) cochlear implant - a small electronic ...
... molecular diagnostics for lung cancer, has announced that Stephen Chubb has ... joined the company as Vice President of Operations and Quality Systems. ... ... Allegro Diagnostics, a leader in the field of molecular diagnostics for ...
... evaluating the predictive value of VENDYS®, the new FDA-approved cardiovascular test, ... American College of Cardiology in Orlando, Florida. The studies, amazingly, show ... fingertips can help detect hidden coronary artery disease. , ... ...
Cached Biology Technology:Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 2Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 3Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 4Cochlear Americas Provides Support for Cochlear Implant Recipients to Pursue Higher Education 5Allegro Diagnostics Expands Board and Executive Team 2Allegro Diagnostics Expands Board and Executive Team 3Allegro Diagnostics Expands Board and Executive Team 4New Discoveries on a Fingertip Test for Screening Silent Heart Disease Promising Results of Recent Clinical Studies to be Presented during the 2009 American College of Cardiology Conference, March 29th - April 1st in Orlando 2New Discoveries on a Fingertip Test for Screening Silent Heart Disease Promising Results of Recent Clinical Studies to be Presented during the 2009 American College of Cardiology Conference, March 29th - April 1st in Orlando 3New Discoveries on a Fingertip Test for Screening Silent Heart Disease Promising Results of Recent Clinical Studies to be Presented during the 2009 American College of Cardiology Conference, March 29th - April 1st in Orlando 4New Discoveries on a Fingertip Test for Screening Silent Heart Disease Promising Results of Recent Clinical Studies to be Presented during the 2009 American College of Cardiology Conference, March 29th - April 1st in Orlando 5