Navigation Links
Making flies sick reveals new role for growth factors in immunity
Date:10/23/2008

lly and functionally very similar a testament to their crucial role as signaling devices in all animals, including humans.

"Dpp from flies has been shown to be completely functional in mammalian cells, and the human version of Dpp BMP 2/4 also works just fine when injected into flies," explains Newfeld.

Newfeld's research builds on earlier observations made by Aaron Johnson, then a graduate student in the Newfeld lab, now a postdoctoral fellow with University of Texas Southwestern Medical Center in Dallas, Tex. Johnson first observed that fruit fly mutants that lacked the ability to generate Dpp protein in one tissue (at a particular time in embryonic development) suffered from excess cell growth in the neighboring tissue. The lack of communication between the tissues resulted in uncontrolled cell growth, in this case in the heart. "Dpp mutant flies have large hearts which are stiffer and beat inefficiently," says Newfeld.

Johnson went on to uncover Dpp's role in heart development. He discovered that when the embryo is nearly ready to hatch, Dpp signals tell heart cells to stop growing. These instructions also insure a proper boundary between the heart and surrounding muscle tissue.

While these were fundamentally exciting discoveries, Newfeld made them even more so when he extended Johnson's project. Since both the heart and the lymph glands in the fly originate from the same tissue (cardiogenic mesoderm), he postulated that when heart development goes awry in fruit fly Dpp mutants that the lymph glands might also be affected.

"One of the functions of the lymph gland in fruit flies is to produce blood cells," notes Newfeld. "This is in contrast to humans where the processes take place in our bone marrow."

With support from Science Foundation Arizona, Frandsen built on Johnson and Newfeld's early discoveries by looking into the mutant fruit fly's immune system and blood cells. He noticed that, in addition
'/>"/>

Contact: Margaret Coulombe
margaret.coulombe@earthlink.net
480-727-8934
Arizona State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Coal and black liquor can produce energy from papermaking
2. Another type of nanotube, a how-to guide to making bamboo-structured carbon nanotubes
3. GBIF making the search for biodiversity research resources easier
4. Making sense of antisense microRNAs
5. Is that sea otter stealing your lunch -- or making it?
6. LSU scientist finds evidence of rain-making bacteria
7. Making sure the wonder materials dont become the wonder pollutant
8. Findings a step toward making new optical materials
9. Research suggests parts of UK could be too hot for wine-making by 2080
10. Research suggests parts of UK could be too hot for wine making by 2080
11. Small protein may have big role in making more bone and less fat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/98rrmr/biometrics_for ... "Biometrics for Banking; Market & Technology Analysis, Adoption ... offering. The adoption for banking purposes ... the forecast is that by 2020 it will ... in delivering biometric systems to the banking industry. ...
(Date:7/9/2015)... , July 9, 2015  Synaptics ... developer of human interface solutions, today announced ... industry,s first fully hardware encapsulated fingerprint sensor ... authentication technology is literally off the grid, ... biometric matching within the fingerprint sensor to ...
(Date:7/8/2015)... YORK , July 8, 2015  BD (Becton, ... BD & Guidepoint Mentor, a new program ... Guidepoint,s expert network services. BD is ... to improve healthcare delivery and outcomes and, with the ... entrepreneur will be able to directly engage with industry ...
Breaking Biology News(10 mins):Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3
... lead to climate change adaptation practices in a ... agriculture has the potential to increase sustainable productivity, ... impacts and mitigate climate change through greenhouse gas ... the lead expert on climate change at the ...
... Most of us would agree that prevention is better ... Clinical Rehabilitation , published by SAGE, indicate that a costly ... in Finland had no measurable effect. , The research was ... 872 participants and their 2440 matched controls for up to ...
... discovery is a step toward implantable replacement cartilage, holding ... osteoarthritis, sports injuries and accidents. Self-assembling sheets ... with growth factor formed thicker, stiffer cartilage than previous ... have found. A description of the research is published ...
Cached Biology News:Climate-smart agriculture should be livelihood-smart too 2Climate-smart agriculture should be livelihood-smart too 3Costly intervention program has no measurable effect on early retirement 2Costly intervention program has no measurable effect on early retirement 3Engineering cartilage replacements 2Engineering cartilage replacements 3
(Date:8/3/2015)... -- Halozyme Therapeutics, Inc. (NASDAQ: HALO ) will webcast ... 2015 on Monday, August 10, 2015 at 4:30 p.m. ... and chief executive officer, will lead the call. On ... for the second quarter 2015. The call ... Halozyme,s corporate website and a recording will be made ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... is processed to get such derivatives as ethylbenzene, a precursor to styrene, used ... within the automotive industry for the production of tyres and other components. Thus, ...
(Date:8/3/2015)... , August 3, 2015 E-QURE ... commercialization of its Bio-electrical Signal Therapy device ("BST Device"), ... of hard to heal chronic wounds, today announced that ... Chemipal, an Israeli distributor specializing in medical devices, for ... Chemipal is a 70 years old, sales, marketing ...
(Date:8/3/2015)... ... 03, 2015 , ... Sterlitech Corporation introduces the compact, quiet, ... analytical laboratory equipment. With optimized features, such as PTFE-coated contact surfaces, an oil-free ... maintenance-free solution for a broad range of vacuum filtration applications. , Featuring a ...
Breaking Biology Technology:Halozyme to Host Second Quarter 2015 Financial Results Conference Call 2World Benzene Market to Surpass 46 MMT by 2020, According to TechSci Research Report Published at MarketPublishers.com 2World Benzene Market to Surpass 46 MMT by 2020, According to TechSci Research Report Published at MarketPublishers.com 3E-QURE Corp Signs Second Distribution Agreement in Israel 2E-QURE Corp Signs Second Distribution Agreement in Israel 3Sterlitech Launches New Line of Vacuum Pumps 2
... Kansas has long,been known for its amber ... have not realized, however, is that Kansas, agricultural,expertise ... beyond the farm,-- namely, the scientific laboratory., ... the,animal-health industry have positioned the state squarely in ...
... 13, 2008 A study published online today in ... insight into the evolutionary conservation of the genes and ... identification of conserved aging-related genes in simple model organisms ... playing a role in human aging and age-associated diseases. ...
... In response to the electronics industrys rallying cry of ... size barrier are likely to come from microchips and ... as organic molecules and polymers. With innovative measurement techniques ... reported at the March Meeting of the American Physical ...
Cached Biology Technology:Op-Ed: The NBAF Would Build on Kansas' Existing Strengths in Bioscience 2Growing old together: Yeast, worms and people may age by similar mechanisms 2Copolymers block out new approaches to microelectronics at NIST 2
... derived from frozen embedded tissue blocks, which ... to ensure the highest quality. Tissues of ... block, sectioned at a thickness of 7 ... are large (3-5 mm in diameter) in ...
... ready-to-use 2-D gel marker mix was designed specifically ... marker mix contains a complement of seven reduced ... value to those who use markers to assess ... weight values of proteins undergoing 2-D separation and ...
...
ID clarifier: platform...
Biology Products: