Navigation Links
Making complex nanoparticles easily reproducible
Date:10/28/2013

CLEVELANDA pair of Case Western Reserve University researchers have received a $424,000 grant from the National Science Foundation's Division of Civil, Mechanical and Manufacturing Innovation, to streamline manufacturing and assembly for two-sided nanoparticles.

Nicole Steinmetz, an assistant professor of biomedical engineering, and Rigoberto Advincula, professor of macromolecular science and engineering, aim to develop processes that can be used by industry.

The engineers are focusing on Janus particles, named for the Roman god of beginnings and transitions.

These-two sided particles could carry a one-two punch of paired medicines, or a drug on one side and a dye on the other that enables doctors using an MRI to see whether the particle penetrates a tumor. Or, the engineers can mix other properties on a particle to provide unique optics for displays, convert energy from one form to another or store data.

"Many things that are discovered never move out of the lab," Steinmetz, an appointee of the Case Western Reserve School of Medicine, said. "The challenge is to make complicated nanoparticles that are easily reproducible."

"We're interested in nanomanufacturing that produces a high yield," Advincula said.

To make the technology realistic for the outside world, the researchers plan to make their particles in one phase, that is, pour all their ingredients into a test tube and produce a particle with different reactive surfaces, designed to host different functions, on each side.

Steinmetz's part of the mix will produce spherical scaffolds using the cowpea mosaic virus or elongated scaffolds using tobacco mosaic virus. The shapes offer different advantages for different uses. She'll engineer the genetics to control dimensions and surface chemistry.

Advincula's ingredients will produce the reactive surfaces in the form of hyperbranching polymers.

"Typically, polymers are long single chains; we specialize in making polymer trees," Advincula said. "Each branch is a reactive group. The branches concentrate the reactive groups at one site, increasing functionality at one location."

The branches, for example, can be made to latch onto target molecules or develop into specific geometric shapes that are recognized by sensors or used to control or produce light.

The researchers believe that if they can make the processing simple and economical enough then pharmaceutical developers, electronics makers and other businesses will take advantage of the nanoparticles, producing devices that contribute to quality of life, sustainability, and technological competitiveness.


'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. Making eye contact doesnt always help your cause
2. Making a common cosmetic and sunblock ingredient safer
3. Scientists discover cosmic factory for making building blocks of life
4. New cell component important to tea and wine-making
5. Not the end of the world: Why Earths greatest mass extinction was the making of modern mammals
6. Making the brain take notice of faces in autism
7. Geoscientists unearth mineral-making secrets potentially useful for new technologies
8. New study reveals important role of insulin in making breast milk
9. New catalyst could cut cost of making hydrogen fuel
10. Making hydrogenation greener
11. Women reject sexually promiscuous peers when making female friends
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... Calif. , Feb. 3, 2016 Vigilant ... Police Department in Missouri ... license plate reader (LPR) data from Vigilant Solutions. ... hit-and-run case in which the victim was walking out of a convenience ... parking space next to his vehicle, striking his vehicle ...
(Date:2/2/2016)... 2016 This BCC Research report provides ... reviewing the recent advances in high throughput ‘omic ... field forward. Includes forecast through 2019. ... and opportunities that exist in the bioinformatic market. ... as well as IT and bioinformatics service providers. ...
(Date:2/2/2016)... 2016   Parabon NanoLabs (Parabon) announced ... Research Office and the Defense Forensics and Biometrics ... the company,s Snapshot Kinship Inference software ... generally, defense-related DNA forensics.  Although Snapshot is best ... and ancestry from DNA evidence), it also has ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... Sunnyvale, CA (PRWEB) , ... February 03, 2016 ... ... publisher of remote Linux and Unix visualization solutions today announced the addition of ... Session Preview allows users to see the current state of the remote Linux ...
(Date:2/3/2016)... -- Silk Therapeutics, Inc., today announced the closing of a $6 ... a total of $10.25 million in Series A funding based ... round was led by existing investor The Kraft Group of ... investors Lear Corporation and Highland Consumer Partners, as well as ... Richard Sackler , MD, with Summer Road, LLC; Erin ...
(Date:2/3/2016)... ... February 03, 2016 , ... ... aid in the rapid development and ongoing quality control of molecular assays targeting ... is extremely high,” Dr. Gregory R. Chiklis, President and CEO of ZeptoMetrix, relayed ...
(Date:2/3/2016)... ... February 03, 2016 , ... Marktech Optoelectronics, a ... wafers, and InP epi wafers based in Latham, New York, offers a ... and Avalanche photodiodes–to Si and InGaAs PIN photodiodes. But it is Marktech's newly ...
Breaking Biology Technology: