Navigation Links
Make or break for cellular tissues
Date:5/16/2012

In a study about to be published in EPJ E, French physicists from the Curie Institute in Paris have demonstrated that the behaviour of a thin layer of cells in contact with an unfavourable substrate is akin to that of thin fluid or elastic films. Understanding the mechanism by which a thin layer of cells splits into disjointed patches, thus breaking the layer's structural integrity, bears great significance because the human tissue, or epithelium, covering organs can only fulfil its role if there are no holes or gaps between the cells.

Thanks to the analogy between the cellular layer examined and the well-understood behaviour of thin liquid films, the scientists Stphane Douezan and Franoise Brochard-Nyart devised a model of the layer's evolution. They considered it as an active, amorphous material made of a continuum of cells. Because it is subject to a constant competition between neighbouring cell-cell and cell-substrate adhesion, it can either maintain its contiguous structure or break.

The authors investigated the layer's stability when subjected to chemical and physical disturbances. In particular, they scrutinised how the cellular layer reacted to a non-adhesive substrate with little chemical affinity with the cells. They also subjected the cells to a physical disturbance by laying them in substrates with low stiffness, such as soft gels.

The researchers observed what is known as the dewetting phenomenon, whereby the cellular layer is ruptured leading to islands of cells interspersed with dry patches. Dewetting is normally observed in viscous polymer films on slippery surfaces. They concluded that the dewetting phenomenon is due to the cells' distinctive sensitivity to the nature of its substrate, particularly to its decreased stiffness. This means that active, living cells remain governed by the laws of physics.


'/>"/>

Contact: Janine Haubenreisser
janine.haubenreisser@springer.com
49-622-148-78414
Springer
Source:Eurekalert

Page: 1

Related biology news :

1. Hidden infections crucial to understanding, controlling disease outbreaks
2. Groundbreaking discovery may lead to stronger antibiotics
3. Breakthrough optical technology to assess colon cancer risk, accuracy
4. Rethinking who should be considered essential during a pandemic flu outbreak
5. Sandia, SES win Popular Mechanics Breakthrough Innovator Award
6. NC State finds new nanomaterial could be breakthrough for implantable medical devices
7. Adult stem cell breakthrough
8. A scientific breakthrough on the control of the bad cholesterol
9. Fractional dose of scarce meningitis vaccine may be effective in outbreak control
10. Fly guy makes memory breakthrough
11. Researchers make breakthrough in the production of double-walled carbon nanotubes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... 13, 2017 UBM,s Advanced Design and Manufacturing ... feature emerging and evolving technology through its 3D Printing ... run alongside the expo portion of the event and ... demonstrations focused on trending topics within 3D printing and ... manufacturing event will take place June 13-15, 2017 at the ...
(Date:4/11/2017)... 11, 2017 Crossmatch®, a globally-recognized leader ... today announced that it has been awarded a ... Activity (IARPA) to develop next-generation Presentation Attack Detection ... "Innovation has been a driving force within Crossmatch ... allow us to innovate and develop new technologies ...
(Date:4/11/2017)... , April 11, 2017 No ... but researchers at the New York University Tandon ... of Engineering have found that partial similarities between ... systems used in mobile phones and other electronic ... The vulnerability lies in the fact ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... ... April 18, 2017 , ... A number of new instruments ... which is part of the Protein and Cell Analysis Education Webinar Series , ... this technology fits in current and future applications. , Many flow cytometers have ...
(Date:4/19/2017)... ... April 18, 2017 , ... ... Labs . The move comes after the company changed focus to making analytical ... new brand and our new technology,” says CEO Robert Hart. Founders Bernardo Cordovez, ...
(Date:4/19/2017)... MA (PRWEB) , ... April 19, 2017 , ... ... a $1.5M Series A-1 financing round. This event adds to several other early ... of its’ Executive and Scientific Teams. , ThermaGenix will use proceeds ...
(Date:4/19/2017)... (PRWEB) , ... April 19, 2017 , ... ... Event, which makes educational webinars accessible to novices as well as experienced ... preanalytical variables of commonly performed coagulation screening tests. , Hemostasis testing quality ...
Breaking Biology Technology: