Navigation Links
Major step for drug discovery and diagnostics
Date:2/12/2009

Researchers from Nano-Science Center, University of Copenhagen and National Centre for Scientific Research, France have developed a general method to study membrane proteins. This method can be used to screen several thousand proteins, and it will reduce the way from development to useful drugs substantially. Already now the pharmaceutical industry is interested and participate in a European consortium that is under construction. The research results are published in the prestigious scientific journal, PNAS.

Membrane proteins are located at the surface of cells and they have a very important role in the communication between the cells in our body. Defective membrane proteins are involved in diseases such as cancer, cardiovascular diseases and neurological diseases, just to mention at few. The researchers have developed a system, where they tie a tag to the protein that attach it to a surface and make it possible to investigate it in the laboratories.

Until now membrane proteins have been difficult to study when they are away from their natural environment in the cell, where there a belt of lipids surrounds them. This belt is essential for their survival and proper function.

Swimsuits for proteins with a tag

With our new method we can study membrane proteins faster and more accurate using less material than before. We are using a kind of swimsuit for the proteins called amphipols. The amphipol substitute for the lipids, surround the membrane protein, and make it soluble in water while keeping its function intact. We attach a tag to the amphipol that will assemble to a surface like a key-lock system. When we have attached the proteins to a surface they can be adapted to several measuring instruments, says Associated Professor Karen Martinez, Department of Neuroscience and Pharmacology and Nano-Science Center at University of Copenhagen.

The researchers have tested their method on several different proteins and the results are very promising. When looking for new drugs, the researchers wants to study the interaction between membrane proteins and other molecules e.g. potential drugs. It can also be used for the detection of virus, bacteria and parasites. A European consortium that is currently under construction, involving approximately 15 different laboratories, including both private companies and universities, will exploit the perspectives of this promising method.

Pharmaceutical industry interested

Our results indicate that the function of the tested proteins is not affected by the immobilisation. This makes it a general method that can be used for studying any membrane protein to virtually any surface. Membrane proteins involved in various diseases can be tested and our results can already now be used in the pharmaceutical industry to screen for new drugs and for diagnostics, says Dr. Jean-Luc Popot, head of the group at National Centre for Scientific Research and, in collaboration with R. Audebert and C. Tribet, the inventor of amphipols.


'/>"/>

Contact: Gitte Frandsen
gf@nano.ku.dk
452-875-0458
University of Copenhagen
Source:Eurekalert  

Related biology news :

1. deCODE discovers cause of major subtype of glaucoma
2. Bleeding, not inflammation, is major cause of early lung infection death
3. Mustafa alAbsi Ph.D. and national team awarded major NIH grant
4. Leading experts cite poor health and nutrition as major barrier to education in developing world
5. Majority of Americans want local action on global warming, says poll
6. How schizophrenia develops: Major clues discovered
7. Major genetic breakthrough for ankylosing spondylitis brings treatment hope
8. NIH selects LIAI for major study on allergy molecular causes and possible treatments
9. Local sources major cause of US near-ground aerosol pollution
10. Tree of life for flowering plants reveals relationships among major groups
11. Humans not the major target of Shiga toxin
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Major step for drug discovery and diagnostics
(Date:6/20/2016)... 20, 2016 Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring announced ... it has secured the final acceptance by all ... Managed Access Systems (MAS) installed. Furthermore, Securus will ... be installed by October, 2016. MAS distinguishes between ...
(Date:6/9/2016)... June 9, 2016 Paris ... Teleste,s video security solution to ensure the safety of people ... during the major tournament Teleste, an international ... and services, announced today that its video security solution will ... to back up public safety across the country. The system ...
(Date:6/2/2016)... 2016   The Weather Company , an IBM Business ... industry-first capability in which consumers will be able to interact ... questions via voice or text and receive relevant information about ... Marketers have long sought an advertising solution that can ... personal, relevant and valuable; and can scale across millions of ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young ... cancer. Members of the Class of 2016 were selected from a pool of ... More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , a ... $1 million in debt financing from Silicon Valley Bank ... automation and to advance its drug development efforts, as ... facility. "SVB has been an incredible strategic ... services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... , ... June 23, 2016 , ... STACS DNA Inc., ... Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as a Field ... DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
Breaking Biology Technology: