Navigation Links
Major international study challenges notions of how genes are controlled in mammals

This release is available in French.

Scientists at the Omics Science Center (OSC) of the RIKEN Yokohama Institute in Japan along with researchers from McGill University and other institutions worldwide are challenging current notions of how genes are controlled in mammals. Three years of intensive research by members of the international FANTOM consortium will culminate with the publication of several milestone scientific papers in Nature Genetics and other journals on April 20.

FANTOM4, the fourth stage of the Functional Annotation of the Mammalian cDNA collaboration, is led by Dr. Yoshihide Hayashizaki of OSC. Dr. Jose Dostie, a biochemist at McGill's Faculty of Medicine joined the FANTOM4 collaboration in 2007 and is its only Canadian member.

For several years, FANTOM researchers have provided the scientific community with extensive data on the genome of mammals, including detailed information on molecular function, biology and individual cell components. Now, the FANTOM4 stage of the collaboration has culminated in a breakthrough that will alter the way scientists understand transcription, the process of cellular copying and reproduction.

"This study really challenges the way we understand cellular differentiation," explained Dr. Dostie, who participated in the primary FANTOM4 research and also authored a satellite paper for publication in the journal Genome Biology. "The dogma right now is that there are so-called 'master regulators,' a series of protein switches that sit in specific places on the genome and induce genes. This is supposed to lead to a cascade that leads to cellular differentiation.

"The FANTOM4 studies show that this thesis is incorrect and there are no master regulators at all," she continued. "It's not like turning everything on like a switch. Instead, it looks like the expression of some genes needs to be decreased while others are increased in a more subtle, but coordinated way."

FANTOM4 is the first report of a large-scale gene network based on an experimental data-set and is likely to generate considerable excitement in the scientific community. The information is important for life science and medical researchers trying to uncover the processes by which cells undergo conversion or become cancerous. It is also related to controlling the growth and differentiation of stem cells and ensuring their safety for use in regenerative medicine.

"We are proud that we have created groundbreaking research in understanding more about how genes regulate cells at the molecular level and we want to acknowledge all consortium members for their great contribution to the research effort," said Dr. Harukazu Suzuki, scientific co-ordinator of the FANTOM4 consortium.


Contact: Mark Shainblum
McGill University

Related biology news :

1. Major aspergillus genomics supplement published by journal Fungal Genetics and Biology
2. Source of major health benefits in olive oil revealed
3. A missing enzyme conveys major heart protection in pre-clinical work
4. Major NSF grant boosts UNH research on hormonal genomics
5. Rising sea levels set to have major impacts around the world
6. Cellulosic biofuel technology will generate low-cost green fuel, says major study
7. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
8. NJIT to host major biomedical engineering showcase and career fair
9. Major step for drug discovery and diagnostics
10. Forsyth scientist receives major grant to support rapid, accurate, affordable test for tuberculosis
11. Foretelling a major meltdown
Post Your Comments:
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, ... Infrastructure, Support & Other Service  The latest ... comprehensive analysis of the global Border Security market ... of $17.98 billion in 2016. Now: In ... in software and hardware technologies for advanced video surveillance. ...
(Date:5/24/2016)... Calif. , May 24, 2016 Ampronix facilitates superior patient care by ... LMD3251MT  3D medical LCD display is the latest premium product recently added to the ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/16/2016)... --  EyeLock LLC , a market leader of iris-based ... IoT Center of Excellence in Austin, Texas ... embedded iris biometric applications. EyeLock,s iris authentication ... with unmatched biometric accuracy, making it the most proven ... platform uses video technology to deliver a fast and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016  Liquid Biotech ... funding of a Sponsored Research Agreement with The ... cells (CTCs) from cancer patients.  The funding will ... levels correlate with clinical outcomes in cancer patients ... will then be employed to support the design ...
(Date:6/24/2016)... 2016  Regular discussions on a range of subjects including ... two entities said Poloz. Speaking at a lecture ... , he pointed to the country,s inflation target, which is ... "In certain areas there ... common economic goals, why not sit down and address strategy ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of ... the Cary 5000 and the 6000i models are higher end machines that use the ... of the spectrophotometer’s light beam from the bottom of the cuvette holder. , ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
Breaking Biology Technology: