Navigation Links
Major international study challenges notions of how genes are controlled in mammals
Date:4/21/2009

This release is available in French.

Scientists at the Omics Science Center (OSC) of the RIKEN Yokohama Institute in Japan along with researchers from McGill University and other institutions worldwide are challenging current notions of how genes are controlled in mammals. Three years of intensive research by members of the international FANTOM consortium will culminate with the publication of several milestone scientific papers in Nature Genetics and other journals on April 20.

FANTOM4, the fourth stage of the Functional Annotation of the Mammalian cDNA collaboration, is led by Dr. Yoshihide Hayashizaki of OSC. Dr. Jose Dostie, a biochemist at McGill's Faculty of Medicine joined the FANTOM4 collaboration in 2007 and is its only Canadian member.

For several years, FANTOM researchers have provided the scientific community with extensive data on the genome of mammals, including detailed information on molecular function, biology and individual cell components. Now, the FANTOM4 stage of the collaboration has culminated in a breakthrough that will alter the way scientists understand transcription, the process of cellular copying and reproduction.

"This study really challenges the way we understand cellular differentiation," explained Dr. Dostie, who participated in the primary FANTOM4 research and also authored a satellite paper for publication in the journal Genome Biology. "The dogma right now is that there are so-called 'master regulators,' a series of protein switches that sit in specific places on the genome and induce genes. This is supposed to lead to a cascade that leads to cellular differentiation.

"The FANTOM4 studies show that this thesis is incorrect and there are no master regulators at all," she continued. "It's not like turning everything on like a switch. Instead, it looks like the expression of some genes needs to be decreased while others are increased in a more subtle, but coordinated way."

FANTOM4 is the first report of a large-scale gene network based on an experimental data-set and is likely to generate considerable excitement in the scientific community. The information is important for life science and medical researchers trying to uncover the processes by which cells undergo conversion or become cancerous. It is also related to controlling the growth and differentiation of stem cells and ensuring their safety for use in regenerative medicine.

"We are proud that we have created groundbreaking research in understanding more about how genes regulate cells at the molecular level and we want to acknowledge all consortium members for their great contribution to the research effort," said Dr. Harukazu Suzuki, scientific co-ordinator of the FANTOM4 consortium.


'/>"/>

Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Related biology news :

1. Major aspergillus genomics supplement published by journal Fungal Genetics and Biology
2. Source of major health benefits in olive oil revealed
3. A missing enzyme conveys major heart protection in pre-clinical work
4. Major NSF grant boosts UNH research on hormonal genomics
5. Rising sea levels set to have major impacts around the world
6. Cellulosic biofuel technology will generate low-cost green fuel, says major study
7. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
8. NJIT to host major biomedical engineering showcase and career fair
9. Major step for drug discovery and diagnostics
10. Forsyth scientist receives major grant to support rapid, accurate, affordable test for tuberculosis
11. Foretelling a major meltdown
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/6/2017)... LA JOLLA, Calif. , Jan. 6, 2017 ... Phase 1 safety studies in healthy volunteers of ... CM4620, intended to treat acute pancreatitis. ... pancreas, is typically a mild disorder, but can ... to organ failure and sepsis, where extended hospital ...
(Date:1/6/2017)...  Delta ID Inc., a leader in consumer-grade iris ... at CES® 2017. Delta ID has collaborated with Gentex ... use of iris scanning as a secure, reliable and ... a car, and as a way to elevate the ... Delta ID and Gentex will demonstrate (booth #7326 LVCC) ...
(Date:1/4/2017)... VEGAS , Jan. 4, 2017  CES ... performance biometric sensor technology, today announced the launch ... sensor systems, the highly-accurate biometric sensor modules ... biometric technology, experience and expertise. The two ... Benchmark designed specifically for hearables, and Benchmark BW2.0, ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... 18, 2017 The global biotechnology services ... billion by 2025, according to a new report ... been adaptive of the function of outsourcing certain ... Among the services outsourced, clinical trial management and ... & Johnson was the first pharmaceutical company to ...
(Date:1/18/2017)... January 18, 2017 According to a new market research ... Cytology, Infectious Disease), & End User (Molecular Diagnostic Laboratories, Academic and Research Institutions) ... reach USD 739.9 Million by 2021 from USD 557.1 Million in 2016, growing ... ... MarketsandMarkets Logo ...
(Date:1/18/2017)... ... January 18, 2017 , ... Total Orthopedics and Sports Medicine ... Solofuse-P™. The operation took place on Wednesday, January 11, 2017 at Long Island ... anterior cervical discectomy and fusion on a 42 year old female who was ...
(Date:1/18/2017)... PRUSSIA, PA (PRWEB) , ... January 18, 2017 ... ... clinical operations again at the CHI SCOPE Summit for Clinical Ops Executives (Hyatt ... in engaging panel discussions to examine vital clinical research issues such as trial ...
Breaking Biology Technology: