Navigation Links
Major discovery opens door to leishmania treatment
Date:10/6/2009

This release is available in French.

Leishmania is a deadly parasitic disease that affects over 12 million people worldwide, with more than 2 million new cases reported every year. Until recently, scientists were unsure exactly how the parasite survives inside human cells. That mystery has now been solved according to a new study published in Science Signaling by a team led by Dr. Martin Olivier a scientist at the Research Institute of the McGill University Health Centre (RI-MUHC) and McGill University. It is hoped the new study will lead to the development of the first prophylactic treatment for leishmania.

Leishmania is typically a sub-tropical and tropical infectious disease transmitted through the bite of female phlebotomine sandflies. The parasites enter the bloodstream and are ingested by macrophage white blood cells where they block immune function and multiply, spreading to other tissues in the body. Leishmania can occur in cutaneous forms, which are generally curable, as well as in a more dangerous and potentially fatal visceral form.

The researchers discovered that a metalloprotease a molecule called GP63 found on the surface of the parasite, plays a role in neutralizing the macrophage's defences. "Our results demonstrate the mechanism through which the GP63 protease alters the function of the macrophages by activating its own negative regulatory mechanisms," says Dr. Olivier. "The infected cells act 'frozen', which hinders the body's innate inflammatory immune response and leads to infection."

The work is significant in that it is the first study that explains how the leishmania parasite blocks the immune function of macrophages. "Our research indicates that the GP63 protease is the target of choice for innovative future treatments, in terms of prevention," says Dr. Olivier.

The GP63 protease directly activates other key molecules that negatively regulate the function of the host cell. "Better control over the activation of these host molecules could be one promising approach to treating leishmania as well as other infectious diseases that use similar infection strategies," he added.


'/>"/>

Contact: Julie Robert
julie.robert@muhc.mcgill.ca
514-843-1560
McGill University Health Centre
Source:Eurekalert

Related biology news :

1. How mitochondrial gene defects impair respiration, other major life functions
2. BioConference Live Attracts Major Life Science Sponsors
3. Restoring a natural root signal helps to fight a major corn pest
4. Family planning a major environmental impact
5. Avoiding hysterectomy: Major interventional radiology E-collection info available
6. Researchers achieve major breakthrough with water desalination system
7. Major breakthrough in early detection and prevention of AMD
8. Researcher garners major award from NIH for further exploration into the mechanisms of obesity
9. Major funding to help cut CO2 emissions
10. Cells split personality is a major discovery into neurological diseases
11. Major international study challenges notions of how genes are controlled in mammals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... -- Perimeter Surveillance & Detection Systems, Biometrics ... Support & Other Service  The latest report ... analysis of the global Border Security market . ... $17.98 billion in 2016. Now: In November ... software and hardware technologies for advanced video surveillance. ...
(Date:5/24/2016)... care by providing unparalleled technology to leaders of the medical imaging industry.  As such, ... to the range of products distributed by Ampronix. Photo - http://photos.prnewswire.com/prnh/20160524/371420 ... ... ... With ...
(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... The global Pyrogen Testing Market ... dominant share in the overall market. The leading players, ... Merck KGaA, held a lion,s share of 51% in ... that these companies are expected to retain their leadership ... do not require rabbit pyrogen testing along with strategic ...
(Date:11/30/2016)... 30, 2016 Biotest Pharmaceuticals Corporation (BPC), a ... announce the addition of its newest plasma collection center ... . The 15,200 square foot state-of-the-art facility officially ... and brings the total number of BPC,s plasma collection ... , BPC,s Chief Executive Officer said "We are pleased ...
(Date:11/30/2016)... Nov. 30, 2016 /PRNewswire/ -  Equicare Health Inc ., ... been recognized as one of the top 100 companies ... international listing that distinguishes the top digital health companies ... great step forward this year continually upgrading our product ... customer base and team," says Len Grenier , ...
(Date:11/30/2016)... and BEIJING , Nov. ... leading commercial provider of genomic services and solutions with ... today that it has completed a USD $75 Million ... Bank Co., Ltd.,s CMB International Capital Management ( ... Investment Management Co., Ltd. ("SDIC Innovation") and Shanghai Sigma ...
Breaking Biology Technology: