Navigation Links
Major component in turmeric enhance effect of chemotherapy drug in head and neck cancer
Date:10/19/2010

Cisplatin's suppressive action involves a different pathway through the tumor suppressor proteins p16 and p53, both proteins that again inhibit the activity of cancer growth promoter NFκB.

"We needed to know the mechanism to help us translate this from the lab into the clinic," Wang said. "That information will help us make better decisions on how to design therapies."

The next step in the clinical setting is to give patients oral curcumin prior to surgery and, after surgery, study the excised tumors to determine curcumin's effect on tumor markers, specifically whether there is reduced expression of markers such as growth promoting NFκB. They also will be monitoring to determine if the curcumin results in any side effects. After that, the team would give curcumin to patients also getting chemotherapy and radiation to see if the tumor suppression found in the cells lines and mouse models can be replicated in humans.

Although turmeric is used in cooking, the amount of curcumin needed to produce a clinical response is much larger, about 500 milligrams. Expecting a positive effect through eating foods spiced with turmeric is not realistic, the researchers said.

Curcumin also has a suppressive effect on other cancers, Wang said, including breast, colon and pancreatic cancers. However, the mechanism of suppression in those cancers has not yet been uncovered. It also may be effective against Alzheimer's and aging, Wang said.


'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California -- Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Gladstone scientists uncover mechanism for the major genetic risk factor of Alzheimers disease
2. Professor Rajeshwar Dayal Tyagi of INRS wins major international award
3. Major moral decisions use general-purpose brain circuits to manage uncertainty
4. Valencia, Spain to host 2 major bone meetings in March 2011
5. Genetic differences that make some people susceptible to meningitis revealed in major new study
6. Cancer drugs may help stop major parasite
7. Major Force Protection and Anti-Terrorist Equipment Demonstration Set for Next May 17-19 in Northern Virginia
8. Lexicon to Present Clinical Data for Diabetes Drug Candidate, LX4211, at Two Major Healthcare Conferences
9. Major magnet grant to advance state-of-the-art in chemical analysis
10. Large majority of Americans still believe in global warming, Stanford poll finds
11. Uncovering the mystery of a major threat to wheat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... order to support the world,s needs to make ... more, new and more efficient catalytic materials and ... including several from Wayne State University, is tackling ... grant from the National Science Foundation. , The ... Multicomponent Materials for Electrocatalytic Cascade Reactions," was to ...
(Date:9/29/2014)... received a five-year, $6 million grant for clinical ... and development of safe and effective treatments for ... the National Institutes of Health, National Institute on ... Medication Development for Cocaine Use Disorder to oversee ... decisions on moving forward with more expensive large-scale ...
(Date:9/29/2014)... review article published online in Behavioral Brain Research ... the brain as a result of chronic alcohol exposure ... , Clinical assessments and research indicate that individuals ... sleep. This can occur when people are actively drinking, ... are abstaining. , "Sleep-wake disturbances can last for ...
Breaking Biology News(10 mins):Wayne State research aims to develop new, more efficient catalytic materials 2New VCU center to target cocaine addiction 2
... 14, 2012 The latest episode in the American ... podcast series describes the development of a new test ... Amid concerns about the threat of terrorist attacks, ... and other nations. One such team has developed a ...
... Irvine researchers have discovered how Salmonella , a bacterium ... in humans, thrives in the digestive tract despite the immune ... explain why Salmonella is difficult to eradicate and ... with Salmonella suffer from diarrhea, fever and abdominal ...
... A parking lot at the edge of the University ... emerging concern for the environment and human health. ... journal Environmental Science & Technology , has found that ... lots throughout the nation, has significant health and ecosystem implications. ...
Cached Biology News:New test could help track down and prosecute terrorists 2UCI-led study uncovers how Salmonella avoids the body's immune response 2UNH research adds to mounting evidence against popular pavement sealcoat 2
(Date:9/30/2014)... September 30, 2014 UFP Technologies, ... specialty packaging has recently introduced a custom insulated ... Pack . The new insulated shipper solves the ... distribution process. UFP Technologies’ BioShell is a universal ... during storage, handling and shipping. The insulated shipper ...
(Date:9/30/2014)... Ontario, Canada (PRWEB) September 30, 2014 Back ... based on 500 square feet. per employee, which included space ... world back then.” says Jeff Howell, partner at Nidea ... advisory firm in Toronto. “By the year 2000, however, ... are now seeing that number come down to 175 to ...
(Date:9/29/2014)... Each year in the US, ... attention. In the military, burn injury is a ... medical care. More than 800 service members sustained ... heal slowly, remain inflamed and often become infected, ... and functionally damaging. While developments in supportive care ...
(Date:9/29/2014)... of the military conflicts in Iraq and Afghanistan, more ... with traumatic brain injury caused by exposure to bomb ... devices, or IEDs. Symptoms of traumatic brain injury can ... nausea, to more severe impairments in memory and cognition. ... has recognized the critical importance and complexity of this ...
Breaking Biology Technology:UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3Faster Healing with Fewer Scars 2Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4
... Pharmaceuticals,Inc. (NYSE: BRL ) today confirmed that ... of the patents listed by Amgen Inc. in,connection ... 90mg., Barr,s Abbreviated New Drug Application (ANDA) ... product was received as acceptable,for filing by the ...
... are to be used in clinical trials ... on a path to finally cure diabetes, ... recently declared its commitment to support Spring Point,Project, a Minnesota non-profit ... of islet tissue for,diabetes care., (Logo: http://www.newscom.com/cgi-bin/prnh/20071214/CLF057LOGO-b ), ...
... as an Antipsychotic Agent with Less Potential for ... Weight Gain and Metabolic Risks, SAN DIEGO, July ... announced that the United States Patent and,Trademark Office (USPTO) ... would provide broad coverage for a pharmaceutical,composition of zonisamide ...
Cached Biology Technology:Barr Confirms Patent Challenge of Sensipar(R) Tablets, 30mg, 60mg and 90mg 2Barr Confirms Patent Challenge of Sensipar(R) Tablets, 30mg, 60mg and 90mg 3Spring Point Project Gains Support of Lions Clubs 2Spring Point Project Gains Support of Lions Clubs 3OREXIGEN(R) Therapeutics Receives Notice of Allowance for U.S. Patent Covering the Composition of Matter in OREX-003 2OREXIGEN(R) Therapeutics Receives Notice of Allowance for U.S. Patent Covering the Composition of Matter in OREX-003 3OREXIGEN(R) Therapeutics Receives Notice of Allowance for U.S. Patent Covering the Composition of Matter in OREX-003 4