Navigation Links
Major component in turmeric enhance effect of chemotherapy drug in head and neck cancer
Date:10/19/2010

Curcumin, the major component in the spice turmeric, when combined with the drug Cisplatin enhances the chemotherapy's suppression of head and neck cancer cell growth, researchers with UCLA's Jonsson Cancer Center have found.

A naturally occurring spice widely used in South Asian and Middle Eastern cooking, Turmeric has long been known to have medicinal properties, attributed to its anti-inflammatory effects. Previous studies have shown it can suppress the growth of certain cancers, said Dr. Marilene Wang, a professor of head and neck surgery, lead author of the study and a Jonsson Cancer Center researcher.

"Head and neck cancers, particularly cases diagnosed in a later stage, are terrible cancers that often require very radical surgeries and chemotherapy and radiation," Wang said. "They often don't present until late, and the structures in the head and neck are so vital that our treatments often cause disfigurement and severe loss of function. So using non-toxic curcumin as a treatment was a very appealing idea."

The study, done in cells in Petri dishes and then in mouse models, appears in the October issue of the journal Molecular Cancer Therapeutics.

In India, women for years have been using turmeric for medicinal purposes, as an anti-aging agent rubbed into their ski, to treat cramps during menstruation, as a poultice on the skin to promote wound healing and as an additive in cosmetics, said scientist Eri Srivatsan, an adjunct professor of surgery and a Jonsson Cancer Center researcher who, along with Wang, has been studying curcumin and its anti-cancer properties for six years.

A 2005 study by Wang and Srivatsan first showed that curcumin suppressed the growth of head and neck cancer cells, first in cells and then in mouse models. In the animal studies, the curcumin was applied directly onto the tumors in paste form because it did not dissolve in saline, which would have allowed it to be injected.


'/>"/>
Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California -- Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Gladstone scientists uncover mechanism for the major genetic risk factor of Alzheimers disease
2. Professor Rajeshwar Dayal Tyagi of INRS wins major international award
3. Major moral decisions use general-purpose brain circuits to manage uncertainty
4. Valencia, Spain to host 2 major bone meetings in March 2011
5. Genetic differences that make some people susceptible to meningitis revealed in major new study
6. Cancer drugs may help stop major parasite
7. Major Force Protection and Anti-Terrorist Equipment Demonstration Set for Next May 17-19 in Northern Virginia
8. Lexicon to Present Clinical Data for Diabetes Drug Candidate, LX4211, at Two Major Healthcare Conferences
9. Major magnet grant to advance state-of-the-art in chemical analysis
10. Large majority of Americans still believe in global warming, Stanford poll finds
11. Uncovering the mystery of a major threat to wheat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... across racial and ethnic groups describe losing eyesight ... day-to-day life, more so than other conditions including: ... of African-Americans, 49% of non-Hispanic whites, 43% of ... disease or ailment is the worst that could ... followed by AIDS/HIV. Hispanics and Asians ranked ...
(Date:9/18/2014)... world-leading provider of scientific, technical and medical information ... Society (ARMS), recognized the academic research achievements of ... Researcher of the Year Awards. , The award ... Centre and in conjunction with the ARMS 2014 ... and New Zealand,s scientific community. Guest of honour ...
(Date:9/18/2014)... in the protective tentacles of host anemones, but new ... of kilometres across the open ocean. Although the process ... this is the first time that the high level ... , Dr Steve Simpson, Senior Lecturer in Marine Biology ... colleagues from the Australian Research Council Centre of Excellence ...
Breaking Biology News(10 mins):Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 3Elsevier and Australasian Research Management Society award scientists at Scopus ceremony 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3
... Astronauts are known to have a higher risk of getting ... with weightlessness, confined crew quarters, being away from family and ... not getting enough sleep - are known to wreak havoc ... immunobiologist Ty Lebsack at the University of Arizona has discovered ...
... 2010 Scientists studying the environmental impact of Hurricane ... city of New Orleans have revealed the ecological impact ... The findings, published in a special issue of ... caused significant ecological damage by altering coastal chemistry and ...
... to ionizing radiation can result in mutations or other ... a new study led by researchers with the U.S. ... has revealed another way in which radiation can promote ... the researchers discovered that radiation exposure can alter the ...
Cached Biology News:Immune system compromised during spaceflight, study finds 2Immune system compromised during spaceflight, study finds 3New research reveals Hurricane Katrina's impact on ecological and human health 2New research reveals Hurricane Katrina's impact on ecological and human health 3Study raises new concerns about radiation and breast cancer 2Study raises new concerns about radiation and breast cancer 3
(Date:9/18/2014)... September 18, 2014 HealthTronics, ... and interventional radiology products and services, announced that ... cryotherapy and cryoablation) versus external beam radiotherapy (EBRT) ... the American Urological Association (MAAUA) Annual Meeting in ... Relative Effectiveness of Cryosurgery and External Beam Radiation ...
(Date:9/18/2014)... , September 18, 2014 /PRNewswire/ ... Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced ... Materials - Global Strategic Business Report" ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes the ... US$ Million by the following Product ...
(Date:9/18/2014)... 2014 Research and Markets has ... Industry Report 2014" report to their offering. ... is a professional and in-depth study on the current ... The report provides a basic overview of the industry ... human albumin market analysis is provided for the international ...
(Date:9/18/2014)... -- Neogen Corporation (Nasdaq: NEOG ) announced today ... Merck Animal Health to market Neogen,s Igenity ® ... Heifer Program consists of genomic tests that offer commercial ... replacement dairy heifers. The genomic tests can be performed ... excellent tool in the decision-making process for breeding and ...
Breaking Biology Technology:HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Merck Animal Health to market Neogen's dairy genomic program 2
... Wisconsin Institute for Discovery It was inevitable that ... interdisciplinary research center on the UW-Madison campus would be ... a $3 billion, 10-year initiative to fund human embryonic ... research is a sizable part of what will happen ...
... House of Representatives has passed a bill that allows ... will be used against them in a patent dispute. ... institutions could count as prior art, said Andy Cohn, ... , ,This could invalidate a patent claim though ...
... this, I am sitting with an angry Mediterranean Sea roaring ... smart Israeli start-ups as the first winter storm hits Tel ... Europe and Israel, taking an assessment of the technology markets ... , ,What strikes me on this visit is the presumed ...
Cached Biology Technology:Doyles proposal is about more than keeping pace with California 2Doyles proposal is about more than keeping pace with California 3Innovation thrives in Europe 2Innovation thrives in Europe 3
Proliferin (N-14)...
... the computing power of your ValveBank system! ... a PC computer running Windows 98, 2000, XP ... programs to disk, print out program listings, then ... one simple step., EasyCode is used for programming ...
...
... formation of phosphodiester bonds in the presence ... hydroxyl and 5' phosphate termini. The unique ... can be performed in 5 minutes (1). ... this enzyme. A T4 DNA Ligase ...
Biology Products: