Navigation Links
Major collaboration uncovers surprising new genetic clues to diabetes
Date:3/30/2008

An international team that included scientists from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), today reported it has identified six more genetic variants involved in type 2 diabetes, boosting to 16 the total number of genetic risk factors associated with increased risk of the disease. None of the genetic variants uncovered by the new study had previously been suspected of playing a role in type 2 diabetes. Intriguingly, the new variant most strongly associated with type 2 diabetes also was recently implicated in a very different condition: prostate cancer.

The unprecedented analysis, published today in the advance online edition of Nature Genetics, combined genetic data from more than 70,000 people. The work was carried out through the collaborative efforts of more than 90 researchers at more than 40 centers in Europe and North America.

None of the genes we have found was previously on the radar screen of diabetes researchers, said one of the papers senior authors, Mark McCarthy, M.D., of the University of Oxford in England. Each of these genes, therefore, provides new clues to the processes that go wrong when diabetes develops, and each provides an opportunity for the generation of new approaches for treating or preventing this condition.

When considered individually, the genetic variants discovered to date account for only small differences in the risk of developing type 2 diabetes. But researchers say when all of the variants are analyzed together, some significant differences in risk are likely to emerge. By combining information from the large number of genes now implicated in diabetes risk, it may be possible to use genetic tools to identify people at unusually high or low risk of diabetes. However, until we know how to use this information to prompt beneficial changes in peoples treatment or lifestyle, widespread genetic testing would be premature," said another
'/>"/>

Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Major international collaboration offers new clues to genetics of type 2 diabetes
2. Black carbon pollution emerges as major player in global warming
3. UCR-led research team uses tiny wasp to wipe out major agricultural pest in Tahiti
4. Epigenetic changes discovered in major psychosis
5. Major scientific push to tackle agricultural productivity and food security in developing world
6. Climate change has major impact on oceans
7. Scientists achieve major genetics breakthrough
8. River plants may play major role in health of ocean coastal waters
9. Academy honors 13 for major contributions to science
10. Major study concludes that global warming is killing off coral
11. Manomet Center awarded major NFWF grant to foster shorebird conservation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... Calif., May 22, 2013 Early screening for prostate ... pregnancy testing is for women, thanks to UC Irvine ... American Chemical Society . , After more than a ... way to clearly identify clinically usable markers for prostate ... detected far sooner, with greater accuracy and at dramatically ...
(Date:5/21/2013)... monitoring" device attached to a whale entangled in fishing ... lines changed a whale,s diving and swimming behavior. The ... eat and migrate, depletes their energy as they drag ... a slow death. , The scientists in this entanglement ... a two-year-old female North Atlantic right whale called Eg ...
(Date:5/21/2013)... that a class of pharmaceuticals can both prevent and ... known as "TSPO ligands," are currently used for certain ... of TSPO ligand in young adult mice when pathology ... when pathology was quite severe," said lead researcher Christian ... ligand reduced measures of pathology and improved behavior at ...
Breaking Biology News(10 mins):UCI chemists devise inexpensive, accurate way to detect prostate cancer 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 3Study reveals how fishing gear can cause slow death of whales 2Study reveals how fishing gear can cause slow death of whales 3Drugs found to both prevent and treat Alzheimer's disease in mice 2
... Researchers at the Umeå Plant Science Centre at the Swedish ... in our understanding of how plants control their flowering. In ... they show how a small molecule that is formed in ... it induces the formation of flowers. This knowledge can lead ...
... you burned your finger on a hot stove? Imagine what ... or feet all the time and know there's virtually nothing ... neuropathic pain, and it's a common complication of many diseases ... this type of pain, which is caused by damage to ...
... the University of Chicago and Argonne National Laboratory ... to study the relationship between biochemical fluctuations within ... it interacts with other cells and its environment. ... in cancer research, drug development and combating bioterrorism. ...
Cached Biology News:Long-sought flower-inducing molecule found 2Scientists use gene transfer technology and common virus to block neuropathic pain in animals 2Scientists use gene transfer technology and common virus to block neuropathic pain in animals 3Scientists use gene transfer technology and common virus to block neuropathic pain in animals 4Scientists use gene transfer technology and common virus to block neuropathic pain in animals 5Scientists create digital bacteria to forge advances in biomedical research 2Scientists create digital bacteria to forge advances in biomedical research 3
(Date:5/21/2013)... BEACH, Fla. , May 21, 2013 /PRNewswire/ ... FCN ), the global business advisory ... their enterprise value (the "Company"), announced that it ... personnel that were formerly included within the Corporate ... Litigation Consulting segment to form a single integrated ...
(Date:5/21/2013)... 21, 2013 Through science fairs, workshops, ... for lab equipment, 25 organizations will continue their work ... optics and photonics in daily life with the aid ... organizations, located in 10 countries, are the first of ... by SPIE, the international society for optics and ...
(Date:5/21/2013)... , May 21, 2013 ... Dialysis and Transplant Association) is the biggest congress in ... replacement therapy. Nearly 10,000 participants are in ... the latest research findings. New pioneering studies have been ... "SOLUBLE FERRIC PYROPHOSPHATE (SFP) ADMINISTERED VIA HEMODIALYSATE REDUCES ESA ...
(Date:5/21/2013)... Austin, TX (PRWEB) May 21, 2013 ... and outdoor security solutions, today announced that Genzyme, a ... more units of Door Detective® CL for a multi-use ... already installed in four other Genzyme buildings, this latest ... had with the tailgate detection device improving ...
Breaking Biology Technology:FTI Consulting Releases Realigned Segment Information Reflecting Newly Combined Health Solutions Practice 2Learning About Light: Education Outreach Projects Funded in 10 Countries Through First Round of SPIE Grants 2Learning About Light: Education Outreach Projects Funded in 10 Countries Through First Round of SPIE Grants 3ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 2ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 3Door Security at Genzyme, a Sanofi Company, Enhanced with Door Detective from Smarter Security 2Door Security at Genzyme, a Sanofi Company, Enhanced with Door Detective from Smarter Security 3
... WASHINGTON, June 15 Congressional Quarterly presents a 360-degree ... of follow-on versions of biotech drugs. This CQ Forum ... interest groups, and leading researchers regarding the complex structures ... possible? Will the availability of these products save money ...
... ADVENTRX Pharmaceuticals, Inc. (NYSE Amex: ANX ) ... of shares of convertible preferred stock pursuant to a registered ... of approximately $2 million. The preferred stock is convertible into ... investor at a price of $0.1105 per share. , ...
... Zentaris Inc. (NASDAQ: AEZS ; TSX: AEZ), ... oncology, today reported that patient follow-up in the open-label ... in benign prostatic hyperplasia (BPH) with its lead endocrinology ... the end of this week. Therefore, data analysis and ...
Cached Biology Technology:ADVENTRX Pharmaceuticals Announces Closing of Financing 2ADVENTRX Pharmaceuticals Announces Closing of Financing 3AEterna Zentaris to Report Data from Safety Study of Phase 3 Program in Benign Prostatic Hyperplasia with Cetrorelix Ahead of Schedule 2AEterna Zentaris to Report Data from Safety Study of Phase 3 Program in Benign Prostatic Hyperplasia with Cetrorelix Ahead of Schedule 3AEterna Zentaris to Report Data from Safety Study of Phase 3 Program in Benign Prostatic Hyperplasia with Cetrorelix Ahead of Schedule 4AEterna Zentaris to Report Data from Safety Study of Phase 3 Program in Benign Prostatic Hyperplasia with Cetrorelix Ahead of Schedule 5
Candida (IgG) -Ab EIA Sample Size: 5 l...
Automated centrifuge for the processing of microplates and tubes; can be integrated into automated process using inexpensive robotics due to its unique sample handling platform....
OptiBuffer is a fully optimised medium, designed for,the electroporation of eukaryotic cells. OptiBuffer,improves both transfection efficiencies and survival,rates over PBS or other standard culture...
...
Biology Products: