Navigation Links
Major clinical trial finds no link between genetic risk factors and 2 top wet AMD treatments
Date:2/12/2013

SAN FRANCISCO February 12, 2013 New findings from a landmark clinical trial show that although certain gene variants may predict whether a person is likely to develop age-related macular degeneration (AMD), a potentially blinding eye disease that afflicts more than nine million Americans, these genes do not predict how patients will respond to Lucentis and Avastin, the two medications most widely used to treat the "wet" form of AMD. This new data from the Comparison of AMD Treatment Trials (CATT), published online in Ophthalmology, the journal of the American Academy of Ophthalmology, found no significant association between four gene variants and outcomes that measured the patients' responses to treatment.

The CATT genetics research team wanted to learn whether the major AMD risk genes could be useful in tailoring treatment with Avastin and Lucentis to individual patients' needs to boost treatment effectiveness and safety for patients. The main CATT study had confirmed that both medications significantly reduce or even reverse vision loss in many patients with wet AMD, but that study also found that treatment effectiveness varied among patients. The CATT genetics study, led by Stephanie Hagstrom, Ph.D., at the Cole Eye Institute at the Cleveland Clinic, clearly showed that the major AMD risk alleles do not predict patients' response to treatment.

This genetics study cohort comprised 73 percent of the 1,149 CATT participants. Cohort patients were evaluated for four gene variants linked to AMD risk: CFH, ARMS2, HTRA1, and C3. The patients' genotypes were then compared to their responses to treatment with Lucentis or Avastin. Both medications are anti-vascular epithelial growth factor (anti-VEGF) therapies that work in similar ways to reduce or prevent abnormal blood vessel growth and leakage. The researchers found no significant associations among the four gene variants and the outcomes that measured the patients' responses to treatm
'/>"/>

Contact: Mary Wade
mwade@aao.org
415-447-0221
American Academy of Ophthalmology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Global Companion Diagnostic Market Worth $19.3 billion by 2023: What it Takes to Become a Major Companion Diagnostic Player
2. Genetics plays major role in victimization in elementary school
3. Major cuts to surging CO2 emissions are needed now, not down the road, study finds
4. Majority of Americans doubt Congress and White House can avoid fiscal cliff
5. Mercury releases contaminate ocean fish: Dartmouth-led effort publishes major findings
6. Major breakthrough in deciphering bread wheats genetic code
7. Major international push to maximize bioscience research to help worlds poorest farmers
8. Baylor University scientist receives major grants for health research on 1991 Gulf War veterans
9. British Library leads the way for sharing data as major institutions sign up to DataCite
10. Whitehead scientists identify major flaw in standard approach to global gene expression analysis
11. Major changes needed to protect Australias species and ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... , Jan. 26, 2015   Epic Sciences , ... cancer, today announced that Murali Prahalad , Ph.D., president ... Medicine World Conference (PMWC) 2015: Silicon Valley, which is ... Mountain View, Calif. on January 26-28, 2015. ... Come of Age as Biomarkers." Last year, Epic Sciences was ...
(Date:2/5/2015)... IRVINE, Calif. , Jan. 27, 2015 ... trusted provider of globally deployed, innovative test ... today announced the delivery of its ... Martin Space Systems Company (LMSSC). GENASYS is ... the demands of mission-critical applications that require ...
(Date:2/5/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market, ... Online CEO Conference on January 29 th at ... , CEO of NXT-ID will present and host a ... smart wallet and its full suite of biometric technologies. ...
Breaking Biology News(10 mins):Epic Sciences to Present at Personalized Medicine World Conference 2015 on the Use of Circulating Tumor Cells as Cancer Biomarkers 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3
... as caterpillars feed, plants may "call for help" by ... The volatiles recruit parasitoids that infect, consume and kill ... such induced plant odours can also be detected by ... the open access journal PLOS Biology shows ...
... through the new consensus statement issued by the ... cell research and regulation. Specifically, tension between ... exchange, but also between eastern and western cultures, ... health care systems. The consensus, titled Statement ...
... northern California, and Alaska increased about nine percent in ... feet, according to the U.S. Forest Service,s Pacific Northwest ... about eight percent to 186 million board feet, compared ... percent of West coast log exports went to China ...
Cached Biology News:The hungry caterpillar: Beware your enemy's enemy's enemy 2East Asia faces unique challenges, opportunities for stem cell innovation 2East Asia faces unique challenges, opportunities for stem cell innovation 3West coast log exports up slightly in third quarter of 2012 2
(Date:3/4/2015)... SANTA BARBARA, CALIFORNIA (PRWEB) March 04, 2015 ... regulatory consulting firm in the life sciences industry, hired ... Compliance. Blewitt leads the Cloud Compliance Services and ... sciences companies utilize cloud based applications while maintaining compliance ... 20 years, Blewitt has been an accomplished life sciences ...
(Date:3/4/2015)... Irvine, CA (PRWEB) March 04, 2015 ... research leader in Personalized Medicine, is excited to ... “Incorporating Genetic Testing to Optimize the Management of ... be available at Medscape.com for the next year. ... medical professionals how to recognize inadequate pain treatments, ...
(Date:3/4/2015)... -- Launched by the Assistance Publique ... December 2011, ,SARAH, - the French national collaborative ... in advanced hepatocellular carcinoma (HCC) has enrolled more than ... SARAH, a large French study of patients with advanced, ... completed patient enrolment, exceeding its 400-patient target, according to ...
(Date:3/3/2015)... NASA astronaut Scott Kelly , who is ... a year living and working on the International Space Station, ... 7 a.m. EDT Monday, March 9. Kelly will ... the final weeks of his training. The interviews will be ... highlighting his mission training and previous spaceflights. To ...
Breaking Biology Technology:USDM Life Sciences Names David Blewitt VP of Cloud Compliance for Regulated Life Sciences 2USDM Life Sciences Names David Blewitt VP of Cloud Compliance for Regulated Life Sciences 3Proove Biosciences Launches CME Accredited Program with Medscape 2Proove Biosciences Launches CME Accredited Program with Medscape 3Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 2Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 3Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 4Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 5NASA Astronaut Scott Kelly Available for Interviews before One-Year Space Station Mission 2
... ... launch of several innovative new programs to aid cash-strapped entrepreneurs and businesses ... aimed at entrepreneurs and offers them the opportunity to finance legal services ... any equity in their start-up companies. The second is aimed at ...
... ROCKAWAY, N.J., Dec. 14 The third edition of ... published by the Infusion Nurses Society (INS), includes Totect(®), the ... group of chemotherapy medications including daunorubicin, doxorubicin, idarubicin and epirubicin ... of cancer since the early 1970s.(2) , According ...
... ... Tester – helping Brookfield move from sheet metal to a plastic enclosure with a ... ... thermoforming company, has completed the delivery of Brookfield Engineering’s Powder Flow Tester – helping ...
Cached Biology Technology:The Prinz Law Office Launches Innovative New Programs to Aid Cash-Strapped Entrepreneurs and Businesses 2Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as the Only Antidote for the Treatment of Anthracycline Extravasation 2Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as the Only Antidote for the Treatment of Anthracycline Extravasation 3Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as the Only Antidote for the Treatment of Anthracycline Extravasation 4Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as the Only Antidote for the Treatment of Anthracycline Extravasation 5Thermofab Helps Brookfield Engineering Move To A Compact Custom Plastic Enclosure 2