Navigation Links
Major breakthrough in the diagnosis of parasitic diseases
Date:4/27/2010

This press release is available in French.

Montreal, April 27, 2010 - Chagas disease is one of the most deadly parasitic diseases in the world. It affects more than 10 million people, primarily in the Americas. In South America alone it kills 50 000 people each year. A reliable and rapid diagnosis is the key in the battle against infection but until now, this has been next to impossible. Dr. Momar Ndao and his team at the Research Institute of the MUHC have developed a new diagnostic approach that will help in the fight against Chagas disease.Their results were recently published in the Journal of Clinical Microbiology.

Endemic in South America, the American trypanosomiasis, or Chagas disease, is transmitted to humans via the parasite Trypanosoma cruzi. The disease is usually transmitted through the bite of an infected insect or 'kissing bug'. The symptoms are variable, but as the disease progresses serious chronic symptoms can appear, such as heart disease and malformation of the intestines. Most people affected may remain without symptoms for years, making diagnosis difficult.

Chagas disease is also transmitted from mother to unborn child and can be passed on for as many as four generations without symptoms. "In other words, a person born in North America by a mother who was infected can transmit the disease to offspring without having traveled," says Dr. Ndao, Laboratory Director of the National Reference Center for Parasitology (NRCP) of the Research Institute. There is an urgent need for action on this disease as it is under-diagnosed and there is no effective treatment.

This situation raises some serious public health concerns with respect to blood transfusions and organ transplants, because many people may be silent carriers of the disease. "The aim of our study was to find new approaches to improve reliability of diagnosis and screening of blood banks," says Dr. Ndao, who is also a researcher at the Centre for Host Parasite Interactions at McGill University.

The researchers have validated a reliable screening technique using mass spectrometry technology that identifies common biological markers - or biomarkers - between the interaction of host (humans) and the parasite. They found that in 99% of cases, the parasites left very specific markers. 'It's as if the parasite left his own signature in the infected person, which could help to diagnose Chagas disease" says Dr. Ndao.

"The use of these biomarkers is a revolution in diagnostic confidence and protection of possible contamination of blood banks," says Dr. Ndao "Moreover, these biomarkers have potential therapeutic effects of paving the way for the development of vaccines for Chagas, which could be extended to other parasitic diseases."


'/>"/>

Contact: Julie Robert
Julie.robert@muhc.mcgill.ca
514-843-1560
McGill University Health Centre
Source:Eurekalert

Related biology news :

1. deCODE discovers cause of major subtype of glaucoma
2. Bleeding, not inflammation, is major cause of early lung infection death
3. Mustafa alAbsi Ph.D. and national team awarded major NIH grant
4. Leading experts cite poor health and nutrition as major barrier to education in developing world
5. Majority of Americans want local action on global warming, says poll
6. How schizophrenia develops: Major clues discovered
7. Major genetic breakthrough for ankylosing spondylitis brings treatment hope
8. NIH selects LIAI for major study on allergy molecular causes and possible treatments
9. Local sources major cause of US near-ground aerosol pollution
10. Tree of life for flowering plants reveals relationships among major groups
11. Humans not the major target of Shiga toxin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... 2, 2016 Perimeter Surveillance & ... Systems, Physical Infrastructure, Support & Other Service  ... offers comprehensive analysis of the global Border ... generate revenues of $17.98 billion in 2016. ... a leader in software and hardware technologies for advanced ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
(Date:5/9/2016)... -- Elevay is currently known as the ... high net worth professionals seeking travel for work   ... there is still no substitute for a face-to-face meeting. ... deal with a firm handshake. This is why wealthy ... citizenship via investment programs like those offered by the ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
(Date:6/23/2016)... 23, 2016 A person commits a crime, and ... to track the criminal down. An outbreak of ... Drug Administration (FDA) uses DNA evidence to track down the ... Sound far-fetched? It,s not. The FDA has increasingly used a ... of foodborne illnesses. Put as simply as possible, whole genome ...
(Date:6/23/2016)... MONICA, Calif. , June 23, 2016  The Prostate Cancer Foundation ... pioneer increasingly precise treatments and faster cures for prostate cancer. Members of the ... institutions across 15 countries. Read More About the Class ... ... ...
(Date:6/23/2016)... ... 2016 , ... Supplyframe, the Industry Network for electronics hardware ... . Located in Pasadena, Calif., the Design Lab’s mission is to bring together ... built and brought to market. , The Design Lab is Supplyframe’s physical representation ...
Breaking Biology Technology: