Navigation Links
Major breakthrough in early detection and prevention of AMD
Date:6/15/2009

P>

"CCR3 chemokine receptor is known to be a key player in the allergic inflammation process, but Dr. Ambati's studies have now identified CCR3 as a key marker of the CNV process involved in AMD. If researchers can determine why CCR3 is expressed in the CNV of AMD patients, they could further understand AMD disease progression," said Dr. Grace L. Shen, director of the ocular immunology and inflammation program at the National Eye Institute.

Ambati's research team was able to detect these same abnormal blood vessels in the living eyes of mice by attaching anti-CCR3 antibodies to tiny semiconductor nanocrystals called "quantum dots" and injecting these into the mice. The antibodies cause the quantum dots to attach to CCR3 on the surface of the abnormal blood vessels, making them visible with conventional ocular angiography techniques, even before they have penetrated the retina. This was not possible before.

"This is an exciting discovery for the millions of people at risk of developing wet macular degeneration, because this new imaging technology introduces the possibility of detecting pathological neovascularization before retinal damage and vision loss occur," said Dr. Stephen J. Ryan, professor of ophthalmology at the University of Southern California and member of the National Academy of Sciences' Institute of Medicine.

The research team discovered that CCR3 not only provides a unique signature for CNV, but the gene actively promotes the growth of these abnormal blood vessels in the eye. Thus the same anti-CCR3 antibodies used to detect CNV could potentially be useful as a clinical treatment to prevent macular degeneration.

The early results look promising. Treatment with anti-CCR3 antibodies reduced CNV in mice by about 70 percent, as opposed to 60 percent with VEGF-based treatments currently in clinical use. Ambati says Phase I clinical trials are not far off.

"The identification of CCR3 on the endothelial cells
'/>"/>

Contact: Keith Hautala
keith.hautala@uky.edu
859-323-6363
University of Kentucky
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Researcher garners major award from NIH for further exploration into the mechanisms of obesity
2. Major funding to help cut CO2 emissions
3. Cells split personality is a major discovery into neurological diseases
4. Major international study challenges notions of how genes are controlled in mammals
5. Major aspergillus genomics supplement published by journal Fungal Genetics and Biology
6. Source of major health benefits in olive oil revealed
7. A missing enzyme conveys major heart protection in pre-clinical work
8. Major NSF grant boosts UNH research on hormonal genomics
9. Rising sea levels set to have major impacts around the world
10. Cellulosic biofuel technology will generate low-cost green fuel, says major study
11. La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Major breakthrough in early detection and prevention of AMD
(Date:7/31/2015)... SHENZHEN , Chine, 31 juillet 2015 /PRNewswire/ ... (ICG-10, www.icg-10.org ) sera organisée par le ... Shenzhen en Chine. ... année. Depuis son inauguration en 2006, l,ICG est ... influentes dans le domaine des « omiques » et c,est ...
(Date:7/31/2015)... Die 10. internationale Konferenz zu Genomik (ICG-10, ... vom 22. bis 25. Oktober 2015 in ... Die Konferenz feiert in diesem Jahr ihr ... ICG weltweit zu einem der einflussreichsten jährlichen Treffen ... dynamischsten, enthusiastischsten und angenehmsten wissenschaftlichen Zusammentreffen. ...
(Date:7/31/2015)... The 10 th International Conference on Genomics ... 22-25, 2015, in Shenzhen , ... 10 th anniversary this year. Since its inauguration in ... annual meetings in the ,omics, fields, and is one of ... ICG-10 focuses on recent breakthroughs and advances in ,omics, ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3The 10th International Conference on Genomics (ICG-10) to Open in October 2
... Colorado (CU) has signed exclusive, worldwide licensing and ... Ltd to develop an enzyme replacement therapy for ... metabolic disease that is often fatal at a ... and includes sponsored-research funding by OT to continue ...
... during a record-setting expedition have yielded new insights about ... the cold, dark, and highly pressurized habitats of the ... Natalya Gallo of Scripps Institution of Oceanography at UC ... CHALLENGE expedition, a project led by James Cameron in ...
... virologist Masahiro Niikura and his doctoral student Nicole Bance are ... new class of molecular compounds capable of killing the influenza ... of a good thing can be a killer, the scientists ... is key to how influenza replicates and spreads. , ...
Cached Biology News:University of Colorado and Orphan Technologies sign agreement 2University of Colorado and Orphan Technologies sign agreement 3Vibrant mix of marine life found at extreme ocean depths, Scripps analysis reveals 2Vibrant mix of marine life found at extreme ocean depths, Scripps analysis reveals 3Influenza study: Meet virus' new enemy 2
(Date:8/27/2015)... , Aug. 27, 2015  Neogen Corporation (NASDAQ: ... stock of United Kingdom -based Lab ... culture media and diagnostic systems. Lab ... a leading provider of microbial testing and diagnostic products ... markets. The company currently sells into more than 70 ...
(Date:8/27/2015)... , Aug. 27, 2015 HUYA Bioscience International ... of the Japan Society of HTLV-1, held this week ... The purpose of the Society is to promote research ... development of medical technology and research related to these ... "HUYA is proud to support this prestigious ...
(Date:8/27/2015)... ... August 27, 2015 , ... Proove Biosciences, a ... the relationship of genetics and hypertension at the International Academy of Cardiology ... British Columbia, Canada. The event, which boasts an extensive overview of the latest ...
(Date:8/26/2015)... -- The Diabetes Research Institute (DRI), a Center of ... of Medicine, announced today that the first patient ... first time a novel transplant technique for insulin-producing ... I/II study builds upon decades of progress in ... step toward the development of the DRI BioHub, ...
Breaking Biology Technology:Neogen acquires U.K.-based Lab M Holdings 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 2Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4
... , BEIJING, June 8 /PRNewswire-Asia/ -- Sinovac ... provider of vaccines in China, announced today that it,begins the production ... received from US CDC and was delivered to the company on ... Chairman, President and CEO of Sinovac, commented, ,In,the midst of a ...
... Offering AccuVein,s AV300 Hand-Held Vein Illumination Device to Membership , ... AccuVein LLC today announced a three year agreement with ... hand-held, non-contact vein illumination device to its members. The ... skin revealing vein position to help the healthcare professional locate ...
... Pasteuria Bioscience announced that it has received registration from ... usgae . This is a critical step towards the ... prevalent in soil that have long been recognized as promising ... , "We,re very pleased to receive this EPA registration," said ...
Cached Biology Technology:Sinovac Begins the Production of Influenza A (H1N1) Vaccine 2Sinovac Begins the Production of Influenza A (H1N1) Vaccine 3AccuVein Inks National Three-Year Group Purchasing Deal With Amerinet 2Pasteuria Bioscience Receives EPA Registration for Nematode Control 2
capacity 250 mL...
... to MSY2/YBOX2 ( Abpromise for ... Antigen: Synthetic peptide derived from ... of human YBX2. (Note: the ... Entrez ...
... CLS number is a ... to easily match Cornings ... no availability yet, please ... Sigma-Aldrich number (Z35,347-7) or ...
Standard Fluka For microscopy (Bact., Hist.)...
Biology Products: