Navigation Links
Maintaining the brain's wiring in aging and disease
Date:12/5/2008

Researchers at the Babraham Institute near Cambridge, supported by the Alzheimer's Research Trust and the Biotechnology and Biological Sciences Research Council (BBSRC), have discovered that the brain's circuitry survives longer than previously thought in diseases of ageing such as Alzheimer's disease. The findings were published today in the journal Brain.

Alzheimer's disease causes nerve cells in the brain to die, resulting in problems with memory, speech and understanding. Little is known about how the nerve cells die, but this new research has revealed how they first lose the ability to communicate with each other, before deteriorating further.

"We've all experienced how useless a computer is without broadband. The same is true for a nerve cell (neuron) in the brain whose wiring (axons and dendrites) has been lost or damaged," explained Dr Michael Coleman the project's lead researcher. "Once the routes of communication are permanently down, the neuron will never again contribute to learning and memory, because these 'wires' do not re-grow in the human brain."

But axons and dendrites are much more than inert fibre-optic wires. They are homes to the world's smallest transport tracks. Every one of our hundred billion nerve cells continuously shuttles hundreds of proteins and intracellular packages out along its axons and dendrites, and back again, during every minute of every day. Without this process, the wires cannot be maintained and the nervous system will cease to function within a few hours.

During healthy ageing this miniature transport system undergoes a steady decline, but the challenges are immense. Axons up a metre long have to survive and function for at least eight or nine decades. Over this period, our homes will need rewiring several times, but in our brains the wires are all original, surviving from childhood. In Alzheimer's disease, axons swell dramatically, ballooning to 10 or 20 times their nor
'/>"/>

Contact: Dr. Claire Cockcroft
claire.cockcroft@bbsrc.ac.uk
44-01-223-496-260
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Page: 1 2

Related biology news :

1. Niacins role in maintaining good cholesterol
2. The satellite navigation in our brains
3. Big brains arose twice in higher primates
4. Brains R Us: Neuroscience and education town hall
5. From brains to behavior: Cold Spring Harbor Protocols features methods for neuroscience research
6. Doctors learn to control their own brains pain responses to better treat patients
7. Managing carbon loss
8. UNC expands brain imaging study of infants at risk for autism
9. Ants may help researchers unlock mysteries of human aging process
10. £20 million to fight virtual crime and treat our aging population
11. UNC study: Text messaging may help children fight off obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced ... Perimeter Security Systems Market" report to their offering. ... American perimeter security market is estimated to grow at a ... market holds a larger share in this market, ...
(Date:12/17/2014)... 15, 2014 Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a ... introduces for the first time a fingerprint sensor in ...
(Date:12/17/2014)... Valencell, a leader in performance biometric data sensor technology, ... such as Intel, Jabra, Atlas, and Scosche to develop ... products will be showcased at CES 2015, taking place ... "Our partners choose PerformTek biometrics, because ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... new drug, teduglutide, offers significant relief for patients ... on intravenous nutrition, according to a new study ... official clinical practice journal of the American Gastroenterological ... massive bowel loss and are unable to absorb ...
... Legionella have evolved a sophisticated system to ... at Ludwig-Maximilians-Universitaet (LMU) in Munich have now identified a ... Legionella is responsible for the so-called Legionnaires, disease, ... The bacteria can also cause Pontiac fever, a flu-like ...
... is recommended worldwide as an initial therapy for ... of children cannot be fully controlled by adrenocorticotropic ... who initially respond to adrenocorticotropic hormone monotherapy, and ... treatment. Feiyong Jia and colleagues from the First ...
Cached Biology News:New treatment offers hope for short-bowel syndrome patients 2Infection biology: How Legionella subverts to survive 2
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart data solutions ... a record-breaking year across the board for the company. ... Platform and our Smart Data solutions, our customers were able ... led to record growth for the company in 2014,” said ...
(Date:1/22/2015)... 2015 zFlo Motion , a US ... an exciting product from a new partner. STT-Systems ... the past 15 years, with offerings in the optical-motion capture, ... IMU system (inertial measurement unit), iSen, is opening eyes around ...
(Date:1/22/2015)... NEW BRUNSWICK , Nueva Jersey , 22 ... Award for Biomedical Research abre hoy su llamada ... las personas cuya investigación científica ha hecho, o tiene ... de la salud humana. Las nominaciones se aceptarán hasta ...
(Date:12/25/2014)... The report “Service Quality Management and Telco ... Type - Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” ... and forecasting of revenues. , Browse 152 market ... in-depth TOC on “Service Quality Management (SQM) and Telco ...
Breaking Biology Technology:Cambridge Semantics Announces Record Results for 2014 23D Motion Capture Just Got Easy 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... technologies from academic research centers, and building innovative companies ... able to tap deeper into federal government dollars. ... relations venture created by a collaboration between the Wisconsin ... the national economic development agency GSP Consulting . ...
... articles on developing start-up companies in the technology or biotechnology sectors. ... 1 of our Early Stage series, we explained how to ... a domain name. Now, in Step 3, we'll address choosing a ... domain name, then you should have simultaneously made sure that this ...
... accelerate the transformation of healthcare research into commercial products ... triangle connecting Milwaukee, Madison, and the Marshfield Clinic ... facilitate scientific collaboration and technology transfer in the state, ... WiSys Technology Foundation, Inc. , the patenting and licensing ...
Cached Biology Technology:New firm to help companies land federal dollars 2Early Stage, Step 3: Naming the entity 2Early Stage, Step 3: Naming the entity 3Early Stage, Step 3: Naming the entity 4WiSys to patent Marshfield Clinic discoveries 2
B-FABP (FL-132)...
Roll of Mesh 5m x 25cm...
Oven mesh sheets, large, 23 x 23cm, pack of 5...
... Protein Phosphatase-2A (PPase-2A) is a serine/threonine phosphatase ... is isolated as the heterodimer of 60kDa ... the ability to dephosphorylate the a-subunit of ... PPase-2A has broad substrate specificity and may ...
Biology Products: