Navigation Links
Magnetic nanotags spot cancer in mice earlier than methods now in clinical use
Date:10/13/2009

h containing magnetic nanoparticle tags that have been tailored to fit specific antibodies. The magnetic nanotags attach themselves to the outer antibody on the sandwich, where they alter the ambient magnetic field in a small but distinct and detectable way that is sensed by the detector.

The protein-detection assays that are currently in use rely on a variety of mechanisms, such as measuring electrical charge, fluorescent signals or pH, all of which are prone to interference from the biological matrix in which the desired proteins reside. While a particular assay may be fine for assessing a protein's concentration in urine, for example, it may perform poorly when applied to a blood sample, as differences in the composition of the matrix affect properties such as pH or electrical charge.

"Our sensors are shown to be rather insensitive to matrix, so that is another key element from a scientific point of view," said Wang. As an example, he said, "We know that in saliva and blood, they have totally different pH values and different chemistry, but they are all nonmagnetic. Magnetically they are just like air. So it does not interfere with our mechanism [of detection]."

Most of the assays currently in use are only able to detect proteins over a narrow range of concentrations before interference of some kind degrades the sensitivity of the assay. That can require a series of assays to be performed on a sample diluted to different strengths, in order to assemble a complete picture of a protein's concentration in the matrix. But again, by using magnetic detection, Wang and his colleagues are able to sidestep such signal degradation.

"With the high sensitivity and the broad range we can look at a big panel of proteins over a wide range of concentrations, and with the matrix insensitivity, we can look at them in different fluids," said Richard Gaster, MD/PhD candidate in bioengineering and medicine, and first author on the Nature Medicin
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Magnetic nano-shepherds organize cells
2. Magnetic nanoparticles navigate therapeutic genes through the body
3. Electromagnetic phantom exorcises specters of metal detector tests
4. Caltech geobiologists discover unique magnetic death star fossil
5. Researchers mimic bacteria to produce magnetic nanoparticles
6. Biomagnetics developed for use in new breast cancer tests
7. UVa biomedical engineering study shows magnetic field can reduce swelling
8. New system would use rotating magnetic field to detect pathogens
9. New magnetic separation technique might detect multiple pathogens at once
10. Do migratory birds see the magnetic field?
11. Magnetic snakes control fluids, gravity-defying droplets, and solving a dragonfly mystery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Magnetic nanotags spot cancer in mice earlier than methods now in clinical use
(Date:7/2/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/jvft55/next_generation ) ... Biometrics Market by Application, Technology, Function & Geography - ... The next generation biometrics market is expected ... of 17.9% between 2015 and 2020 Travel ... Safran SA ( France ), ...
(Date:6/29/2015)... , June 24, 2015 ... of the "Latin America Biomedical Sensors Market - ... offering. The Latin America Biomedical Sensors market ... CAGR of 2.04% over the period 2014-2020 ... adaptable to the genetic formulation of each individual. These ...
(Date:6/25/2015)... June 25, 2015  TAKE Solutions Ltd., a global ... the United States Patent and Trademark Office (USPTO) for ... leverages TAKE Solutions, Clinical Accelerators to reduce the time ... compared to standardization without the accelerators), thus reducing time ... At the heart of the patented Clinical ...
Breaking Biology News(10 mins):Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3Latin America Biomedical Sensors Market Report 2015-2020 2TAKE Solutions Awarded Patent By USPTO 2
... have found a way to pull pure oxygen from ... and a room-temperature glass of water. ,Because oxygen ... using solar electricity to split water into those elements--a ... One of the chief obstacles to that green-energy scenario ...
... United States, Lyme disease is the most frequently reported ... These animal-borne diseases can make people very sick, and ... crucial to protecting the public. Scientists at the Cary ... $750,000 in grant funding from the U.S. Environmental Protection ...
... University of New Hampshire researchers have tagged one ... They are the first free-swimming leatherbacks ever tagged in ... an endangered species, were tagged July 17, 26 and ... tracking data, allowing scientists to better understand these elusive, ...
Cached Biology News:Water refineries? 2Water refineries? 3EPA funds ground-breaking Lyme disease research 2UNH researchers tag first-ever free-swimming leatherback turtles in New England 2UNH researchers tag first-ever free-swimming leatherback turtles in New England 3
(Date:7/27/2015)... ... July 27, 2015 , ... Production of high tenacity filament yarn of ... in the EU. For instance, it surpassed the EUR 106 million mark (in value ... 2010. Germany is a major producer, while Italy is a key consumer. , ...
(Date:7/27/2015)... -- Research presented at the 2015 AACC Annual Meeting ... that led to a fingerprick Ebola test becoming the ... receive approval from the World Health Organization (WHO). This ... West Africa by identifying suspected ... isolate and treat these patients much faster than is ...
(Date:7/27/2015)... YORK , July 27, 2015 ... today announced the winners of its annual Klerman ... research by scientists who have been supported by ... career scientists to pursue innovative ideas in neurobiological ... "proof" of concept for the early detection, treatment, ...
(Date:7/27/2015)... ... 27, 2015 , ... Visual Assay was named as a finalist for the ... technologies and services of the past year. More than 70 judges selected the finalists, ... will be announced at the 2015 R&D 100 Awards Dinner on November 13 at ...
Breaking Biology Technology:High Tenacity Filament Yarn of Viscose Rayon Consumption to Grow Swiftly in the EU, Forecasts BAC Reports in New Study Available at MarketPublishers.com 2Rapid Ebola Test Could Play Key Role in Efforts to End Lingering Outbreak 2Rapid Ebola Test Could Play Key Role in Efforts to End Lingering Outbreak 3Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 2Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 3Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 4Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 5Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 6Visual Assay® Named Finalist in 53rd Annual R&D 100 Awards 2
... ITMN ) today announced that Daniel G. Welch, Chairman, ... Deutsche,Bank,s 2008 Biotech Boston Confab on November 11, 2008 ... audio webcast of the presentation, investors and other,interested parties ... InterMune,s,corporate website at http://www.intermune.com . The company recommends,logging ...
... Human Genome Sciences,Inc. (Nasdaq: HGSI ) announced ... Confab will be webcast and may be accessed at, ... A member of Human Genome Sciences, senior management team ... at 2:50 PM Eastern Time., Investors interested in ...
... that its executives will be speaking at the following,investor conferences, and ... Credit Suisse Global Health Care Conference, Phoenix, AZ ... Time, Piper Jaffray Health Care Conference, ... 2008 at 2.00 p.m. Eastern Time Accessing Webcasts, To ...
Cached Biology Technology:Cepheid to Webcast Upcoming Financial Presentations 2
Enables rapid purification of double-stranded DNA fragments = 200 bp, including, for example, PCR reaction products, DNA fragments obtained in restriction enzyme digests, or double-stranded cDNA...
Silica bead method is an economic method of DNA extraction from agarose...
5 minutes from gel band to purified DNA...
BD IMag Anti-Mouse CD90.2 (Thy1.2) Particles-MSC 2 x 109 cells...
Biology Products: