Navigation Links
Magnetic nanotags spot cancer in mice earlier than methods now in clinical use
Date:10/13/2009

h containing magnetic nanoparticle tags that have been tailored to fit specific antibodies. The magnetic nanotags attach themselves to the outer antibody on the sandwich, where they alter the ambient magnetic field in a small but distinct and detectable way that is sensed by the detector.

The protein-detection assays that are currently in use rely on a variety of mechanisms, such as measuring electrical charge, fluorescent signals or pH, all of which are prone to interference from the biological matrix in which the desired proteins reside. While a particular assay may be fine for assessing a protein's concentration in urine, for example, it may perform poorly when applied to a blood sample, as differences in the composition of the matrix affect properties such as pH or electrical charge.

"Our sensors are shown to be rather insensitive to matrix, so that is another key element from a scientific point of view," said Wang. As an example, he said, "We know that in saliva and blood, they have totally different pH values and different chemistry, but they are all nonmagnetic. Magnetically they are just like air. So it does not interfere with our mechanism [of detection]."

Most of the assays currently in use are only able to detect proteins over a narrow range of concentrations before interference of some kind degrades the sensitivity of the assay. That can require a series of assays to be performed on a sample diluted to different strengths, in order to assemble a complete picture of a protein's concentration in the matrix. But again, by using magnetic detection, Wang and his colleagues are able to sidestep such signal degradation.

"With the high sensitivity and the broad range we can look at a big panel of proteins over a wide range of concentrations, and with the matrix insensitivity, we can look at them in different fluids," said Richard Gaster, MD/PhD candidate in bioengineering and medicine, and first author on the Nature Medicin
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Magnetic nano-shepherds organize cells
2. Magnetic nanoparticles navigate therapeutic genes through the body
3. Electromagnetic phantom exorcises specters of metal detector tests
4. Caltech geobiologists discover unique magnetic death star fossil
5. Researchers mimic bacteria to produce magnetic nanoparticles
6. Biomagnetics developed for use in new breast cancer tests
7. UVa biomedical engineering study shows magnetic field can reduce swelling
8. New system would use rotating magnetic field to detect pathogens
9. New magnetic separation technique might detect multiple pathogens at once
10. Do migratory birds see the magnetic field?
11. Magnetic snakes control fluids, gravity-defying droplets, and solving a dragonfly mystery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Magnetic nanotags spot cancer in mice earlier than methods now in clinical use
(Date:8/27/2014)... -- Duke University researchers have identified a gene that ... OSCA1, encodes a protein in the cell membrane of ... the plant,s water conservation machinery accordingly. , "It,s ... professor of biology at Duke. , The findings, ... , could make it easier to feed the world,s ...
(Date:8/27/2014)... neural circuits in the brain of mice, scientists ... The research, led by Howard Hughes Medical Institute ... Technology (MIT), reveals that the connections between the ... about an experience and the part of the ... experience are malleable. , Altering those connections ...
(Date:8/27/2014)... is entering what is described by the Volunteer Wildfire ... The Eastern Cape provincial government warned residents in certain ... winds and veld fires. A high veld fire ... along the coast in the Great Kei and Mnquma ... and during thunderstorms. The thunderstorms bring lightning strikes ...
Breaking Biology News(10 mins):Water 'thermostat' could help engineer drought-resistant crops 2Researchers change the emotional association of memories 2Researchers change the emotional association of memories 3Researchers change the emotional association of memories 4
... the Smiley lab at the Trudeau Institute have now identified ... be used as a vaccine. This single "subunit" could potentially ... cell-stimulating plague vaccine. The new data is featured in the ... "To date, there has been little progress in the development ...
... the next big innovation in sustainable climate technology? ... for Business Law and Regulation at Case Western Reserve ... do just that. "Technology-induced prizes have a long ... on a Climate Prize Rewarding Energy Innovation to Achieve ...
... Highlights: Advanced technologies create ... Radio was integrated easily with Army,s cellular biometric network ... Harris Corporation,s (NYSE: HRS ... infrastructure for various mission scenarios at the Empire Challenge 2011 ...
Cached Biology News:Trudeau Institute announces new discovery in battle against plague and bacterial pneumonias 2CWRU law professor eyes prize-based incentives to generate climate innovation 2Harris Corporation's Highband Networking Radio Provides Mobile, Wideband Communications for Empire Challenge 2011 2Harris Corporation's Highband Networking Radio Provides Mobile, Wideband Communications for Empire Challenge 2011 3
(Date:8/27/2014)... is how plants survive impact by the huge ... while using this energy for photosynthesis. The hypothesis ... blades quickly dissipate the energy throughout the entire ... DTU Physics have now managed to successfully ,film, ... contain light-absorbing proteins which play a role in ...
(Date:8/27/2014)... , Aug. 27, 2014  Lisa Kulik saw fireworks ... July 4 holiday, thanks to a groundbreaking retinal implant ... internationally renowned clinician-researcher at the University of Southern California ... Peoria, Ariz. resident who has ... victims of sight. On June 2, she became the ...
(Date:8/27/2014)... -- Reportbuyer.com has added a new market research ... Rational View https://www.reportbuyer.com/product/1595336/The-Graphene-Opportunity---A-Rational-View.html ... similar amount of hype currently surrounds graphene, with ... water treatment, but is graphene the only solution? ... Opportunity Report, authored by Tim Harper ...
(Date:8/27/2014)... 27, 2014  ARCH Venture Partners, one of ... the development of seed and early-stage advanced technology ... closed with more than $400 million in subscriptions. ... subscription target by more than $150 million. ... strength and potential of our approach to finding ...
Breaking Biology Technology:DTU researchers film protein quake for the first time 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 3USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 5The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4Latest ARCH Venture Partners Fund Closes Above $400 Million 2Latest ARCH Venture Partners Fund Closes Above $400 Million 3
... educated nearly 80,000 patients in over 30 states on ... disease and treatment options since 1997, DEERFIELD, Ill., ... Baxter Healthcare Corporation,s Kidney Patient,Educator (KPE) program, an ambitious ... disease (CKD) and treatment options to,nearly 80,000 kidney disease ...
... at 11:45 am ET on November 8, 2007, ... (Nasdaq: TARG ) today announced its participation,in ... Conference, taking place November 8, 2007 at the,Hilton ... Officer of Targanta, will be presenting at 11:45 ...
... MNKD ) today announced results from a ... GLP-1 (glucagon-like peptide) on Technosphere,particles that is delivered ... as an open-label, dose escalation, controlled safety and,tolerability ... was assigned to one of five dose levels ...
Cached Biology Technology:Baxter Kidney Patient Education Program Celebrates Tenth Anniversary 2Baxter Kidney Patient Education Program Celebrates Tenth Anniversary 3Baxter Kidney Patient Education Program Celebrates Tenth Anniversary 4Targanta to Present at 9th Annual Mass Opportunities Investment Conference 2MannKind Announces Positive Results from a Phase 1a Study of a GLP-1 Formulation 2MannKind Announces Positive Results from a Phase 1a Study of a GLP-1 Formulation 3MannKind Announces Positive Results from a Phase 1a Study of a GLP-1 Formulation 4
... ViaSure Kit is used in conjunction with the ... cells automatically. The ViaSure Staining Reagent uses ... Acridine Orange and Ethidium Bromide to identify live ... while the EasyCount Slide 6 Multi-well Slide ...
... The Mini Trans-Blot cell and PowerPac Basic power ... to membranes. The Mini Trans-Blot cell accommodates two ... gel holder cassettes, modular electrode assembly, Bio-Ice cooling ... 4 fiber pads. The PowerPac basic power supply, ...
...
... SPE is a powerful, high-throughput workstation dedicated specifically for automating Solid Phase Extraction ... large volumes aqueous solution extractions (up to 2000ml's). ... ... ...
Biology Products: