Navigation Links
Magnetic nanoparticles navigate therapeutic genes through the body
Date:3/5/2009

Health professionals send genes and healthy cells on their way through the bloodstream so that they can, for example, repair tissue damage to arteries. But do they reach their destination in sufficient quantities? Scientists of the PTB have developed a highly sensitive measuring method with which the efficiency of this therapy can be investigated: Small magnetic particles which are situated on the planted gene or on the planted cell can with the aid of an external magnetic field be specifically directed to the location of the damage. There the researchers determine, accurate to the picogram per cell, the quantity of the magnetic material and thus also the quantity of the therapeutically effective genes or cells. In a joint study with the University of Bonn it became clear: By means of the magnetic method it is possible to dramatically increase the efficiency of the gene transfer in comparison to the non-magnetic method.

Magnetic nanoparticles can support or even enable gene transfer under clinically relevant experimental conditions. For the transduction of human cells, gene carriers were coupled to magnetic nanoparticles and dragged into the cells by magnetic field gradients. The efficiency of magnetic transduction turned out to be much higher than the nonmagnetic procedure. An additional welcome side effect is the "magnetization" of the cells after the incorporation of nanoparticles. This may enable the targeted transport of the cells to regions of interest.

A closer look at the underlying mechanism of magnetic gene transfer was taken by the quantification of the magnetic material that was delivered to the cells. The required highly sensitive measurements in the range of a few picogramm per cell were made by PTB using magnetorelaxometry. The good correlation between measurement data and gene transfer encourages to use magnetorelaxometry for monitoring the efficiency of gene and cell transfer, possibly even in vivo.


'/>"/>

Contact: Dr. Lutz Trahms
Lutz.Trahms@ptb.de
49-303-481-7213
Physikalisch-Technische Bundesanstalt (PTB)
Source:Eurekalert

Page: 1

Related biology news :

1. Magnetic snakes control fluids, gravity-defying droplets, and solving a dragonfly mystery
2. Do migratory birds see the magnetic field?
3. New magnetic separation technique might detect multiple pathogens at once
4. New system would use rotating magnetic field to detect pathogens
5. UVa biomedical engineering study shows magnetic field can reduce swelling
6. Biomagnetics developed for use in new breast cancer tests
7. Researchers mimic bacteria to produce magnetic nanoparticles
8. Caltech geobiologists discover unique magnetic death star fossil
9. Electromagnetic phantom exorcises specters of metal detector tests
10. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
11. MIT: Remote-control nanoparticles deliver drugs directly into tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... June 17, 2015  Crossmatch™, a leading provider ... its U.are.U ® 4500 fingerprint readers have ... Eateries, Inc., a San Jose, CA ... increase security, improve accountability and reduce fraud at ... non-repudiable identity confirmation for employee sign in and ...
(Date:6/15/2015)... June 16, 2015 According to ... by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, ... 2020" published by MarketsandMarkets, The Natural Language Processing Market ... CAGR of 18.4% for the forecast period 2015-2020. ... 46 F igures spread   through 155 P ...
(Date:6/10/2015)... , June 10, 2015 ... "3D Sensor Market by Technology (Ultrasound, TOF, Structured ... (consumer Electronics, Entertainment, Automotive) and by Geography - ... by MarketsandMarkets, the market is expected to reach ... of 25.51% between 2015 and 2020. ...
Breaking Biology News(10 mins):Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3Natural Language Processing Market Worth $13.4 Billion by 2020 2Natural Language Processing Market Worth $13.4 Billion by 2020 3Natural Language Processing Market Worth $13.4 Billion by 2020 4Natural Language Processing Market Worth $13.4 Billion by 2020 53D Sensor Market Worth $3,319.71 Million by 2020 23D Sensor Market Worth $3,319.71 Million by 2020 33D Sensor Market Worth $3,319.71 Million by 2020 4
... A new NOAA report assesses the role National ... in U.S. waters. The report found the National ... role developing tools that allow the participation of numerous ... to protect habitat and biodiversity while minimizing user conflicts. ...
... summer of 2010 has been agonizingly hot in much of ... on global warming. Scientists have been looking at ways the ... heat, and one process had intrigued them, a premise that ... that could absorb carbon dioxide, one of the major compounds ...
... population centers, the city is the most vulnerable to ... who developed a new tool to estimate the frequency ... Geography doctoral student Jill C. Malmstadt, working with ... Jagger, created the Hurricane Risk Calculator and used it ...
Cached Biology News:NOAA report reviews ecosystem management in national marine sanctuaries 2Ice-free ocean may not absorb CO2, a component in global warming 2Ice-free ocean may not absorb CO2, a component in global warming 3Windy cities: Researchers invent new tool to calculate hurricane risk 2Windy cities: Researchers invent new tool to calculate hurricane risk 3
(Date:6/30/2015)... 30, 2015 /PRNewswire/ - Resverlogix Corp. ("Resverlogix") (TSX:RVX) ... of Resverlogix have approved the resolutions relating to: ... of 5,600,000 units at a price of $2.67 ... being comprised of one common share and 0.075358 ... approximately CAD$15 million; and (ii) the amendment to ...
(Date:6/30/2015)... ... June 30, 2015 , ... uBiome ... new insights on mechanics of fecal microbiota transplantation in C. difficile patients. , ... microbiome of patients undergoing fecal microbiota transplantation (FMT) as a treatment for Clostridium ...
(Date:6/30/2015)... SAN DIEGO , June 30, 2015 /PRNewswire/ ... Continuing Education in Biosciences (CCE/Bio) and UC San ... microbial fermentation, to be held Aug.  12 – ... agenda ).  This three-day workshop provides an intense ... in industrial biotechnology, and is well-suited to biologists, ...
(Date:6/30/2015)... ... June 30, 2015 , ... Smarter Alloys ... a revolutionary new archwire that allows orthodontists to simultaneously apply different forces to ... efficacy of SmartArch. “We’re thrilled about taking SmartArch one step closer to commercial ...
Breaking Biology Technology:Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 3uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3UC San Diego Extension to Offer Third Annual Microbial Fermentation Workshop 2New case studies for SmartArch orthodontic archwire paves way to product launch later this year 2
... May 4 Medivation, Inc. (Nasdaq: MDVN ) ... and webcast with management to discuss first quarter 2009 financial ... 11, 2009, at 4:30 p.m. Eastern Time. A press ... be released after markets close on May 11, 2009.Interested parties ...
... BioTech Inc. (OTC Bulletin Board: PLMO; Frankfort Borse: PLO) ... Officer of its Pulmo Science Inc. subsidiary and the ... paper at the 5th International Symposium on Peptide Receptors ... from June 26th to 29th. The paper, which ...
... Tectonics Corporation,s (NYSE AMEX LLC: ETC) ("ETC" or ... addition of Mr. Ray Wyngarden as Western Regional ... for expanding market awareness of the BARA-MED(R) XD ... in the western portion of the United States.Mr. ...
Cached Biology Technology:Medivation Announces First Quarter 2009 Financial Results Teleconference and Webcast on May 11, 2009 2Pulmo BioTech Inc. Announces Paper to be Presented at Symposium 2Pulmo BioTech Inc. Announces Paper to be Presented at Symposium 3Environmental Tectonics Corporation Expands BioMedical Systems Division Sales Staff 2Environmental Tectonics Corporation Expands BioMedical Systems Division Sales Staff 3
Narrow-mouth has heavy-duty rim. Approximate graduations are in durable white enamel. Extra large marking space. capacity 125 mL Special grade: student grade...
... Rabbit polyclonal to MSY2/YBOX2 ( ... Antigen: Synthetic ... amino acids 178-227 of human YBX2. ... sequence is proprietary). ...
Standard Fluka For microscopy (Bact., Hist.)...
... and Freedom EVO384R are fast multi-channel pipetting ... three different sizes, with a multi-channel head ... significant time saving, with true parallel processing ... of your assays with the Freedom EVOware ...
Biology Products: